All Phenotypes Gfi1<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gfi1⁺
wild type
MGI:2433063

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	\Gfi1^{tm2.1(GFP/cre/ERT2)Gan}/\Gfi1⁺	B6.Cg-Gfi1^{tm2.1(GFP/cre/ERT2)Gan}/Gan	MGI:6477645
ht2	\Gfi1^Gen/\Gfi1⁺	C57BL/6J-Gfi1^Gen	MGI:5318525
ht3	\Gfi1^{tm5.1(GFI1*)Tmo}/\Gfi1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5468272
cn4	\Gfi1^tm1(cre)Gan/\Gfi1⁺ \Rfx1^tm1.1Wrth/\Rfx1^tm1.1Wrth \Rfx3^tm2Wrth/\Rfx3^tm2Wrth	involves: 129 * 129S7/SvEvBrd	MGI:5907531
cn5	\Gfi1^tm1(cre)Gan/\Gfi1⁺ \Rfx3^tm2Wrth/\Rfx3^tm2Wrth	involves: 129 * 129S7/SvEvBrd	MGI:5907529
cn6	\Bmp2^tm1Brd/\Bmp2^tm1.1Mis \Gfi1^tm1(cre)Gan/\Gfi1⁺	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J	MGI:4430834
cn7	\Gfi1^{tm5.1(GFI1*)Tmo}/\Gfi1⁺ \Kras^tm4Tyj/\Kras⁺ \Tg(Mx1-cre)1Cgn/0	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA	MGI:5468270
cn8	\Pkhd1l1^{tm2c(EUCOMM)Hmgu}/\Pkhd1l1^{tm2c(EUCOMM)Hmgu} \Gfi1^tm1(cre)Gan/\Gfi1⁺	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6N	MGI:6379249
cn9	\Rest^tm1.1Bban/\Rest⁺ \Gfi1^tm1(cre)Gan/\Gfi1⁺	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * FVB/N	MGI:6378689
cn10	\Gfi1^tm1(cre)Gan/\Gfi1⁺ \Rfx1^tm1.1Wrth/\Rfx1^tm1.1Wrth	involves: 129S7/SvEvBrd	MGI:5907530

Allelic Composition	\Gfi1^{tm2.1(GFP/cre/ERT2)Gan}/\Gfi1⁺
Genetic Background	B6.Cg-Gfi1^{tm2.1(GFP/cre/ERT2)Gan}/Gan

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfi1^{tm2.1(GFP/cre/ERT2)Gan} mutation (0 available); any Gfi1 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:297267 )

Allelic Composition	\Gfi1^Gen/\Gfi1⁺
Genetic Background	C57BL/6J-Gfi1^Gen

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfi1^Gen mutation (1 available); any Gfi1 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:182679 )

N	• mice exhibit normal NK cell accessory cells

abnormal NK cell differentiation ( J:182679 )

• NK cell maturation is blocked at the double positive stage unlike in wild-type mice

abnormal myelopoiesis ( J:182679 )

• mice exhibit an accumulation of atypical myeloid precursors in the bone marrow compared with wild-type mice

absent neutrophils ( J:182679 )

• in the blood, spleen, bone marrow, liver, lungs and lymph nodes

abnormal NK cell physiology ( J:182679 )

• hyporesponsive towards YCA-1 target cells in vitro and MHC-I-deficient splenocytes in vivo

• hyporesponsive towards stimulation of NK1.1-, NKp46- or NKG2D- and Ly49D-activatng receptors

• transplant experiments confirm that NK cell hyporeactivity involves a cell-extrinsic factor

• NK cells exhibit higher rates of proliferation and poorer survival compared with wild-type cells

• however, responsiveness to PMA and ionomycin stimulation is normal and NK cells regain full reactivity in a wild-type environment

decreased NK cell degranulation ( J:182679 )

• after stimulation with YAC-1 target cells

hematopoietic system

abnormal NK cell differentiation ( J:182679 )

• NK cell maturation is blocked at the double positive stage unlike in wild-type mice

abnormal myelopoiesis ( J:182679 )

• mice exhibit an accumulation of atypical myeloid precursors in the bone marrow compared with wild-type mice

absent neutrophils ( J:182679 )

• in the blood, spleen, bone marrow, liver, lungs and lymph nodes

abnormal NK cell physiology ( J:182679 )

• hyporesponsive towards YCA-1 target cells in vitro and MHC-I-deficient splenocytes in vivo

• hyporesponsive towards stimulation of NK1.1-, NKp46- or NKG2D- and Ly49D-activatng receptors

• transplant experiments confirm that NK cell hyporeactivity involves a cell-extrinsic factor

• NK cells exhibit higher rates of proliferation and poorer survival compared with wild-type cells

• however, responsiveness to PMA and ionomycin stimulation is normal and NK cells regain full reactivity in a wild-type environment

decreased NK cell degranulation ( J:182679 )

• after stimulation with YAC-1 target cells

cellular

decreased NK cell degranulation ( J:182679 )

• after stimulation with YAC-1 target cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
severe congenital neutropenia		DOID:0050590	OMIM:PS202700	J:182679

Allelic Composition	\Gfi1^{tm5.1(GFI1*)Tmo}/\Gfi1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfi1^{tm5.1(GFI1*)Tmo} mutation (0 available); any Gfi1 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal definitive hematopoiesis ( J:192927 )

• proliferative expansion of granulomonocytic progenitors

cellular

abnormal mitosis ( J:192927 )

• proliferative expansion of granulomonocytic progenitors

Allelic Composition	\Gfi1^tm1(cre)Gan/\Gfi1⁺ \Rfx1^tm1.1Wrth/\Rfx1^tm1.1Wrth \Rfx3^tm2Wrth/\Rfx3^tm2Wrth
Genetic Background	involves: 129 * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfi1^tm1(cre)Gan mutation (0 available); any Gfi1 mutation (32 available)
Rfx1^tm1.1Wrth mutation (0 available); any Rfx1 mutation (44 available)
Rfx3^tm2Wrth mutation (0 available); any Rfx3 mutation (68 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

abnormal inner hair cell kinocilium morphology ( J:227631 )

• inner hair cells retain kinocilia at P15 unlike in wild-type cells where kinocilia are retracted by this time

decreased cochlear outer hair cell number ( J:227631 )

• widespread loss of outer hair cells by P15

absent cochlear outer hair cells ( J:227631 )

• by P90

cochlear inner hair cell degeneration ( J:227631 )

• progressive degeneration associated with sporadic fusion of stereocilia on some of the remaining bundles by P90

abnormal cochlear outer hair cell physiology ( J:227631 )

• increase in expression of pro-apoptotic factors in outer hair cells at P12 and P15

impaired hearing ( J:227631 )

• rapid progressive hearing loss beginning at P22 with no measurable hearing by 3 months of age

deafness ( J:227631 )

• no measurable hearing by 3 months of age

nervous system

abnormal inner hair cell kinocilium morphology ( J:227631 )

• inner hair cells retain kinocilia at P15 unlike in wild-type cells where kinocilia are retracted by this time

decreased cochlear outer hair cell number ( J:227631 )

• widespread loss of outer hair cells by P15

absent cochlear outer hair cells ( J:227631 )

• by P90

cochlear inner hair cell degeneration ( J:227631 )

• progressive degeneration associated with sporadic fusion of stereocilia on some of the remaining bundles by P90

abnormal cochlear outer hair cell physiology ( J:227631 )

• increase in expression of pro-apoptotic factors in outer hair cells at P12 and P15

cellular

abnormal inner hair cell kinocilium morphology ( J:227631 )

• inner hair cells retain kinocilia at P15 unlike in wild-type cells where kinocilia are retracted by this time

increased apoptosis ( J:227631 )

• increase in expression of pro-apoptotic factors in outer hair cells at P12 and P15

Allelic Composition	\Gfi1^tm1(cre)Gan/\Gfi1⁺ \Rfx3^tm2Wrth/\Rfx3^tm2Wrth
Genetic Background	involves: 129 * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfi1^tm1(cre)Gan mutation (0 available); any Gfi1 mutation (32 available)
Rfx3^tm2Wrth mutation (0 available); any Rfx3 mutation (68 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:227631 )

N	• normal hearing thresholds at 3 months of age

Allelic Composition	\Bmp2^tm1Brd/\Bmp2^tm1.1Mis \Gfi1^tm1(cre)Gan/\Gfi1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2^tm1.1Mis mutation (0 available); any Bmp2 mutation (25 available)
Bmp2^tm1Brd mutation (0 available); any Bmp2 mutation (25 available)
Gfi1^tm1(cre)Gan mutation (0 available); any Gfi1 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:156945 )

• a 6.5 dB shift in threshold is detected at 16kHz in 3-6 month-old mice compared to controls; at 9-10 months, hearing thresholds are comparable to controls

Allelic Composition	\Gfi1^{tm5.1(GFI1*)Tmo}/\Gfi1⁺ \Kras^tm4Tyj/\Kras⁺ \Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfi1^{tm5.1(GFI1*)Tmo} mutation (0 available); any Gfi1 mutation (32 available)
Kras^tm4Tyj mutation (12 available); any Kras mutation (88 available)
Tg(Mx1-cre)1Cgn mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:192927 )

• of all pIpC-treated mice faster than control mice

hematopoietic system

myeloid hyperplasia ( J:192927 )

• all pIpC-treated mice die of myeloproliferative disorder accompanied by an expansion of myeloid cells in the bone marrow, an infiltration of myeloid cells in the spleen, and the appearance of blast cells in the blood faster than control mice

immune system

myeloid hyperplasia ( J:192927 )

Allelic Composition	\Pkhd1l1^{tm2c(EUCOMM)Hmgu}/\Pkhd1l1^{tm2c(EUCOMM)Hmgu} \Gfi1^tm1(cre)Gan/\Gfi1⁺
Genetic Background	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfi1^tm1(cre)Gan mutation (0 available); any Gfi1 mutation (32 available)
Pkhd1l1^{tm2c(EUCOMM)Hmgu} mutation (1 available); any Pkhd1l1 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:280240 )

• no viable homozygotes are produced

Allelic Composition	\Rest^tm1.1Bban/\Rest⁺ \Gfi1^tm1(cre)Gan/\Gfi1⁺
Genetic Background	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfi1^tm1(cre)Gan mutation (0 available); any Gfi1 mutation (32 available)
Rest^tm1.1Bban mutation (0 available); any Rest mutation (92 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

cochlear inner hair cell degeneration ( J:265659 )

deafness ( J:265659 )

nervous system

cochlear inner hair cell degeneration ( J:265659 )

Allelic Composition	\Gfi1^tm1(cre)Gan/\Gfi1⁺ \Rfx1^tm1.1Wrth/\Rfx1^tm1.1Wrth
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:227631 )

N	• normal hearing thresholds at 3 months of age

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