All Phenotypes Pou4f2<+> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pou4f2⁺
wild type
MGI:2432966

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Opn4^{tm1.1(cre)Saha}/Opn4⁺ Pou4f2^tm2.1Nat/Pou4f2⁺	involves: 129 * C57BL/6	MGI:5285910
cn2	Opn4^{tm2.1(cre/ERT2)Saha}/Opn4⁺ Pou4f2^tm2.1Nat/Pou4f2⁺	involves: 129 * C57BL/6	MGI:5285911
cn3	Opn4^{tm1.1(cre)Saha}/Opn4⁺ Pou4f2^tm4(DTA)Whk/Pou4f2⁺ Tg(CAG-Bgeo/ALPP)1Lbe/0	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5285913
cn4	Opn4^{tm1.1(cre)Saha}/Opn4⁺ Pou4f2^tm4(DTA)Whk/Pou4f2⁺	involves: 129S/SvEv * C57BL/6	MGI:5285914
cn5	Opn4^{tm1.1(cre)Saha}/Opn4^tm1Yau Pou4f2^tm4(DTA)Whk/Pou4f2⁺	involves: 129S/SvEv * C57BL/6	MGI:5285915
cn6	Pou4f2^tm4(DTA)Whk/Pou4f2⁺ Tg(CAG-cre/Esr1*)5Amc/0	involves: 129S/SvEv * C57BL/6 * CBA	MGI:3838797

Allelic Composition	Opn4^{tm1.1(cre)Saha}/Opn4⁺ Pou4f2^tm2.1Nat/Pou4f2⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn4^{tm1.1(cre)Saha} mutation (0 available); any Opn4 mutation (33 available)
Pou4f2^tm2.1Nat mutation (1 available); any Pou4f2 mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal suprachiasmatic nucleus morphology ( J:174940 )

• medial regions of the suprachiasmatic nucleus are not innervated at all

abnormal innervation ( J:174940 )

• the suprachiasmatic nucleus (SCN) is sparsely innervated by Pou4f2-positive ipRGCs (intrinsically photosensitive retinal ganglion cells)

Allelic Composition	Opn4^{tm2.1(cre/ERT2)Saha}/Opn4⁺ Pou4f2^tm2.1Nat/Pou4f2⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn4^{tm2.1(cre/ERT2)Saha} mutation (1 available); any Opn4 mutation (33 available)
Pou4f2^tm2.1Nat mutation (1 available); any Pou4f2 mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal suprachiasmatic nucleus morphology ( J:174940 )

• with injection of 500 ug tamoxifen intraperitoneally at P14, medial regions of the suprachiasmatic nucleus are not innervated at all

abnormal innervation ( J:174940 )

• with injection of 500 ug tamoxifen intraperitoneally at P14, suprachiasmatic nucleus (SCN) is sparsely innervated by Pou4f2-positive ipRGCs (intrinsically photosensitive retinal ganglion cells)

Allelic Composition	Opn4^{tm1.1(cre)Saha}/Opn4⁺ Pou4f2^tm4(DTA)Whk/Pou4f2⁺ Tg(CAG-Bgeo/ALPP)1Lbe/0
Genetic Background	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn4^{tm1.1(cre)Saha} mutation (0 available); any Opn4 mutation (33 available)
Pou4f2^tm4(DTA)Whk mutation (1 available); any Pou4f2 mutation (7 available)
Tg(CAG-Bgeo/ALPP)1Lbe mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal olivary pretectal nucleus morphology ( J:174940 )

• and olivary pretectal nucleus (OPN) projections are eliminated, compared to controls

abnormal innervation ( J:174940 )

• innervation of the intergeniculate leaflet (IGL) is markedly reduced

decreased retina ganglion cell number ( J:174940 )

• all non-M1 retinal ganglion cells are ablated in the retinas, with only about 200 Pou4f2-negative cells detected (200/2000); these remaining fibers innervated the SCN to the same extent as control Pou4f2^tm2.1Nat/+ Opn4^{tm1.1(cre)Saha/+} animals

vision/eye

decreased retina ganglion cell number ( J:174940 )

Allelic Composition	Opn4^{tm1.1(cre)Saha}/Opn4⁺ Pou4f2^tm4(DTA)Whk/Pou4f2⁺
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:174940 )

N	• mutants are able to photoentrain (their circadian phase) like controls; also, activity

impaired pupillary reflex ( J:174940 )

• the papillary light reflex (PLR) is significantly attenuated at high and low light intensities in the middle of the day (zeitgerber time 8, ZT8); in the middle of the night (ZT20), mice show no PLR

abnormal circadian behavior period ( J:174940 )

• animals show a minor deficit in period lengthening under constant light conditions

nervous system

decreased retina ganglion cell number ( J:174940 )

• only 200 M1 (Pou4f2-negative) ipRGCs (intrinsically photosensitive retinal ganglion cells) are detected in the retinas

vision/eye

vision/eye phenotype ( J:174940 )

N	• visual acuity is comparable to wild-type animals

impaired pupillary reflex ( J:174940 )

decreased retina ganglion cell number ( J:174940 )

• only 200 M1 (Pou4f2-negative) ipRGCs (intrinsically photosensitive retinal ganglion cells) are detected in the retinas

Allelic Composition	Opn4^{tm1.1(cre)Saha}/Opn4^tm1Yau Pou4f2^tm4(DTA)Whk/Pou4f2⁺
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn4^{tm1.1(cre)Saha} mutation (0 available); any Opn4 mutation (33 available)
Opn4^tm1Yau mutation (0 available); any Opn4 mutation (33 available)
Pou4f2^tm4(DTA)Whk mutation (1 available); any Pou4f2 mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal olivary pretectal nucleus morphology ( J:174940 )

• and olivary pretectal nucleus (OPN) projections are eliminated, compared to controls

• no fibres are observed in the shell of the OPN

abnormal innervation ( J:174940 )

• innervation of the intergeniculate nucleus (IGL) is markedly reduced

decreased retina ganglion cell number ( J:174940 )

• only 200 M1 (Pou4f2-negative) ipRGCs (intrinsically photosensitive retinal ganglion cells) are detected in the retinas; these remaining fibers innervated the SCN to the same extent as control Pou4f2^tm2.1Nat/+ ;Opn4^{tm1.1(cre)Saha/+} animals

vision/eye

decreased retina ganglion cell number ( J:174940 )

Allelic Composition	Pou4f2^tm4(DTA)Whk/Pou4f2⁺ Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background	involves: 129S/SvEv * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou4f2^tm4(DTA)Whk mutation (1 available); any Pou4f2 mutation (7 available)
Tg(CAG-cre/Esr1*)5Amc mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal optic nerve morphology ( J:146558 )

• reduced cross-sectional area by 48.8% in 3 months after a 5 day course of tamoxifen treatment

• cross-sectional area reduced to 19.7% of controls at ten months after a 5 day course of tamoxifen treatment

• axons disorganized

optic nerve degeneration ( J:146558 )

• progressive degeneration over the course of ten months after a 5 day course of tamoxifen treatment

• severe axon degeneration and vacuolation

• empty or abnormal myelin sheaths

optic nerve atrophy ( J:146558 )

thin retina ganglion layer ( J:146558 )

• 60% reduction in the number of cells of the ganglion layer one month after a 5 day course of tamoxifen treatment

abnormal vision ( J:146558 )

• 33% of time spent in the light as opposed to 6% for controls after 1-2 hours of dark adaptation

nervous system

gliosis ( J:146558 )

• reactive gliosis triggered one month after a 5 day course of tamoxifen treatment

abnormal optic nerve morphology ( J:146558 )

• reduced cross-sectional area by 48.8% in 3 months after a 5 day course of tamoxifen treatment

• cross-sectional area reduced to 19.7% of controls at ten months after a 5 day course of tamoxifen treatment

• axons disorganized

optic nerve degeneration ( J:146558 )

• progressive degeneration over the course of ten months after a 5 day course of tamoxifen treatment

• severe axon degeneration and vacuolation

• empty or abnormal myelin sheaths

optic nerve atrophy ( J:146558 )

cellular

gliosis ( J:146558 )

• reactive gliosis triggered one month after a 5 day course of tamoxifen treatment

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24