Phenotypes associated with this allele

• Allele Symbol: Nes⁺
• Allele Name: wild type
• Allele ID: MGI:2432873
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Fam171a2^em1Smoc/Fam171a2^em1Smoc Nes^em1(cre)Smoc/Nes^+	involves: C57BL/6J	MGI:8187602
cx2	Nes^em1Pqt/Nes^+ Rr400^em1Pqt/Rr400^+	C57BL/6J-Nes^em1Pqt Rr400^em1Pqt	MGI:7447497

Genotype
MGI:8187602

cn1

• Allelic Composition: Fam171a2^em1Smoc/Fam171a2^em1Smoc; Nes^em1(cre)Smoc/Nes⁺
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal brain physiology ( J:362731 )

• reduced accumulation of recombinant alpha-synuclein preformed fibrils following a 3-month incubation period compared to similarly treated wild-type controls

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:362731 )

• following 3-month incubation period with recombinant alpha-synuclein preformed fibrils loss of TH-positive neurons and fiber degeneration is reduced compared to similarly treated wild-type controls

• spread of phospho-ser129 alpha-synuclein pathology in key brain regions at 6 months after treatment is reduced compared to similarly treated wild-type controls

Genotype
MGI:7447497

cx2

• Allelic Composition: Nes^em1Pqt/Nes⁺; Rr400^em1Pqt/Rr400⁺
• Genetic Background: C57BL/6J-Nes^em1Pqt Rr400^em1Pqt

embryo

embryo phenotype ( J:314040 )

• viable, mice born at expected Mendelian ratios

growth/size/body

growth/size/body region phenotype ( J:314040 )

• no obvious phenotype

nervous system

nervous system phenotype ( J:314040 )

• no obvious CNS phenotype