Phenotypes associated with this allele

• Allele Symbol: Ewsr1⁺
• Allele Name: wild type
• Allele ID: MGI:2432806
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ewsr1^tm1b(EUCOMM)Wtsi/Ewsr1^+	C57BL/6N-Ewsr1^tm1b(EUCOMM)Wtsi/Tcp	MGI:5757061
cn2	Ewsr1^tm2(FLI1*)Sblee/Ewsr1^+ Tg(CAG-cre/Esr1*)5Amc/0	involves: 129S6/SvEvTac * C57BL/6 * CBA	MGI:4429149
cn3	Ewsr1^tm1Sblee/Ewsr1^+ Tg(CAG-cre/Esr1*)5Amc/0	involves: 129S6/SvEvTac * C57BL/6 * CBA	MGI:4429150
cn4	Ewsr1^tm1(ERG)Thr/Ewsr1^+ Rag1^tm1(cre)Thr/Rag1^+	involves: 129S/SvEv	MGI:3603039

Genotype
MGI:5757061

ht1

• Allelic Composition: Ewsr1^{tm1b(EUCOMM)Wtsi}/Ewsr1⁺
• Genetic Background: C57BL/6N-Ewsr1^{tm1b(EUCOMM)Wtsi}/Tcp
• Cell Lines: EPD0781_4_G03

Data Sources

IMPC Data for Ewsr1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased grip strength ( J:211773 )

♂

IMPC - TCP

hyperactivity ( J:211773 )

♂

IMPC - TCP

hematopoietic system

increased leukocyte cell number ( J:211773 )

IMPC - TCP

increased lymphocyte cell number ( J:211773 )

IMPC - TCP

homeostasis/metabolism

increased circulating alkaline phosphatase level ( J:211773 )

♀

IMPC - TCP

edema ( J:211773 )

IMPC - TCP

immune system

increased leukocyte cell number ( J:211773 )

IMPC - TCP

increased lymphocyte cell number ( J:211773 )

IMPC - TCP

limbs/digits/tail

short tibia ( J:211773 )

♀

IMPC - TCP

skeleton

short tibia ( J:211773 )

♀

IMPC - TCP

Genotype
MGI:4429149

cn2

• Allelic Composition: Ewsr1^{tm2(FLI1*)Sblee}/Ewsr1⁺; Tg(CAG-cre/Esr1*)5Amc/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

mortality/aging

premature death ( J:156860 )

• after tamoxifen injection, within 4 to 6 days mice become moribund and die

cellular

increased fibroblast apoptosis ( J:156860 )

• 24 hours after tamoxifen application MEF cultures begin to die and caspase-3 activity increases

increased renal tubule apoptosis ( J:156860 )

• after tamoxifen injection, increase in TUNEL+ cells in epithelia

renal/urinary system

increased renal tubule apoptosis ( J:156860 )

• after tamoxifen injection, increase in TUNEL+ cells in epithelia

Genotype
MGI:4429150

cn3

• Allelic Composition: Ewsr1^tm1Sblee/Ewsr1⁺; Tg(CAG-cre/Esr1*)5Amc/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

normal phenotype

no abnormal phenotype detected ( J:156860 )

• no effects on survival even after 6 months following tamoxifien injection

• no phenotype of MEFS with tamoxifen

Genotype
MGI:3603039

cn4

• Allelic Composition: Ewsr1^tm1(ERG)Thr/Ewsr1⁺; Rag1^tm1(cre)Thr/Rag1⁺
• Genetic Background: involves: 129S/SvEv

neoplasm

increased T cell derived lymphoma incidence ( J:98679 )

• associated with leukemia

increased leukemia incidence ( J:98679 )

• mutant mice develop leukemia involving T cells with infiltrating lymphoblasts in the bone marrow, liver, and kidney

immune system

increased T cell derived lymphoma incidence ( J:98679 )

• associated with leukemia

increased lymphocyte cell number ( J:98679 )

• associated with leukemia

hematopoietic system

increased T cell derived lymphoma incidence ( J:98679 )

• associated with leukemia

increased lymphocyte cell number ( J:98679 )

• associated with leukemia

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:98679 )

• associated with leukemia