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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mc4r+
wild type
MGI:2432567
Summary 13 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Mc4rMhdahwe13/Mc4r+ C3HeB/FeJ-Mc4rMhdahwe13 MGI:5699978
ht2
 		Mc4rGlu3/Mc4r+ C57BL/6J-Mc4rGlu3 MGI:3758178
ht3
 		Mc4rm3Btlr/Mc4r+ C57BL/6J-Mc4rm3Btlr MGI:5695307
ht4
 		Mc4rM4Btlr/Mc4r+ C57BL/6J-Mc4rM4Btlr MGI:6114077
ht5
 		Mc4rPkcp/Mc4r+ C57BL/6J-Mc4rPkcp MGI:3603648
ht6
 		Mc4rtm1Lowl/Mc4r+ involves: 129S4/SvJae * C57BL/6 MGI:5526070
ht7
 		Mc4rtm1.1Fbz/Mc4r+ involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NTac MGI:5707334
ht8
 		Mc4rGlu3/Mc4r+ involves: 129S6/SvEvTac MGI:3026692
ht9
 		Mc4rY302C/Mc4r+ involves: C3HeB/FeJ * C57BL/6J MGI:3688525
ht10
 		Mc4rI194F/Mc4r+ involves: C3HeB/FeJ * C57BL/6J MGI:3688524
ht11
 		Mc4rGlu3/Mc4r+ involves: C57BL/6J MGI:3026691
cn12
 		Gpr45em2Zz/Gpr45em2Zz
Mc4rtm3.1(cre)Lowl/Mc4r+ 		involves: 129S6/SvEvTac * C57BL/6 MGI:8216705
cx13
 		Mc4rtm1Lowl/Mc4r+
Mrap2tm1.1Maj/Mrap2+ 		involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 MGI:5526071


Genotype
MGI:5699978
ht1
Allelic
Composition		 Mc4rMhdahwe13/Mc4r+
Genetic
Background		 C3HeB/FeJ-Mc4rMhdahwe13
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc4rMhdahwe13 mutation (1 available); any Mc4r mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased body weight ( J:82809 )
• mutant mice exhibit greatly increased body weights, with mutant females weighing 37-48 g and mutant males 42-48 g.




Genotype
MGI:3758178
ht2
Allelic
Composition		 Mc4rGlu3/Mc4r+
Genetic
Background		 C57BL/6J-Mc4rGlu3
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc4rGlu3 mutation (1 available); any Mc4r mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased body weight ( J:116205 )
• at 8 weeks, male mice are larger (26.5+/-0.4 g) than wild-type mice (24.9+/-0.4 g)




Genotype
MGI:5695307
ht3
Allelic
Composition		 Mc4rm3Btlr/Mc4r+
Genetic
Background		 C57BL/6J-Mc4rm3Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc4rm3Btlr mutation (0 available); any Mc4r mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased body weight ( J:225939 )
• intermediate




Genotype
MGI:6114077
ht4
Allelic
Composition		 Mc4rM4Btlr/Mc4r+
Genetic
Background		 C57BL/6J-Mc4rM4Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc4rM4Btlr mutation (0 available); any Mc4r mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased body weight ( J:255207 )




Genotype
MGI:3603648
ht5
Allelic
Composition		 Mc4rPkcp/Mc4r+
Genetic
Background		 C57BL/6J-Mc4rPkcp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc4rPkcp mutation (1 available); any Mc4r mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased body mass index ( J:98867 )
• mutants exhibit increased body mass as compared to a normal mouse




Genotype
MGI:5526070
ht6
Allelic
Composition		 Mc4rtm1Lowl/Mc4r+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc4rtm1Lowl mutation (2 available); any Mc4r mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
obese ( J:199365 )




Genotype
MGI:5707334
ht7
Allelic
Composition		 Mc4rtm1.1Fbz/Mc4r+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc4rtm1.1Fbz mutation (0 available); any Mc4r mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased body weight ( J:225022 )
• at ~6-7 weeks of age, heterozygotes show an increase in body weight that is intermediate between that of homozygous mutant and wild-type littermates
increased body length ( J:225022 )
• at ~20 weeks of age, heterozygotes of both sexes show a ~5% increase in snout-to-anus distance relative to wild-type controls

adipose tissue
increased abdominal fat pad weight ( J:225022 )
• analysis of abdominal body composition of dead mice at 25-28 weeks of age revealed that heterozygotes show a gain in fat mass intermediate to that observed in homozygous mutant and wild-type littermates

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:225022 )
N
• heterozygotes display normal energy intake and assimilation relative to wild-type controls




Genotype
MGI:3026692
ht8
Allelic
Composition		 Mc4rGlu3/Mc4r+
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc4rGlu3 mutation (1 available); any Mc4r mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased susceptibility to weight gain ( J:85113 )

homeostasis/metabolism




Genotype
MGI:3688525
ht9
Allelic
Composition		 Mc4rY302C/Mc4r+
Genetic
Background		 involves: C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc4rY302C mutation (0 available); any Mc4r mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased body weight ( J:113730 )
• higher than wild-type
increased susceptibility to weight gain ( J:113730 )
• observed weight gain is significantly greater than wild-type between 5 and 20 weeks of age; more pronounced in females than males
• heterozygotes display intermediate weight gain, between homozygotes and wild-type




Genotype
MGI:3688524
ht10
Allelic
Composition		 Mc4rI194F/Mc4r+
Genetic
Background		 involves: C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc4rI194F mutation (0 available); any Mc4r mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased body weight ( J:113730 )
• higher than wild-type
increased susceptibility to weight gain ( J:113730 )
• observed weight gain is significantly greater than wild-type between 5 and 20 weeks of age; males and females show similar weight gain to homozygotes




Genotype
MGI:3026691
ht11
Allelic
Composition		 Mc4rGlu3/Mc4r+
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc4rGlu3 mutation (1 available); any Mc4r mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased susceptibility to weight gain ( J:85113 )

homeostasis/metabolism




Genotype
MGI:8216705
cn12
Allelic
Composition		 Gpr45em2Zz/Gpr45em2Zz
Mc4rtm3.1(cre)Lowl/Mc4r+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr45em2Zz mutation (0 available); any Gpr45 mutation (26 available)
Mc4rtm3.1(cre)Lowl mutation (1 available); any Mc4r mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
increased body weight ( J:367505 )
• mice exhibit increased body weight, fat weight and lean weight at 16 weeks of age
increased susceptibility to diet-induced obesity ( J:367505 )
• mice fed a high-fat diet starting at 6 weeks of age and maintained for 4 weeks exhibit increased body weight and fat weight

homeostasis/metabolism
increased susceptibility to diet-induced obesity ( J:367505 )
• mice fed a high-fat diet starting at 6 weeks of age and maintained for 4 weeks exhibit increased body weight and fat weight




Genotype
MGI:5526071
cx13
Allelic
Composition		 Mc4rtm1Lowl/Mc4r+
Mrap2tm1.1Maj/Mrap2+
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc4rtm1Lowl mutation (2 available); any Mc4r mutation (44 available)
Mrap2tm1.1Maj mutation (0 available); any Mrap2 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
obese ( J:199365 )




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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory