All Phenotypes Wnt4<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Wnt4⁺
wild type
MGI:2432384

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Wnt4^{em1(IMPC)Hmgu}/Wnt4⁺	C57BL/6NCrl-Wnt4^{em1(IMPC)Hmgu}/Ieg	MGI:8176342
ht2	Wnt4^{tm2(EGFP/cre/ERT2)Amc}/Wnt4⁺	involves: 129/Sv * 129S/SvEv * C57BL/6 * C57BL/6J	MGI:7543488
cn3	Hnf1b^tm1Sce/Hnf1b⁺ Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺	involves: 129P2/OlaHsd	MGI:5471842
cn4	Hnf1b^tm1Ics/Hnf1b⁺ Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺	involves: 129P2/OlaHsd	MGI:5471841
cn5	Hnf1b^tm1Ics/Hnf1b^tm1Sce Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺	involves: 129P2/OlaHsd	MGI:5471840
cn6	Dkk1^tm1.1Svo/Dkk1^tm1.2Svo Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:5013425
cn7	Tcf21^tm2.1Seq/Tcf21^tm1Jrt Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:5613386
cx8	Wnt4^tm1Amc/Wnt4⁺ Wnt5a^tm1Amc/Wnt5a^tm1Amc Wnt5b^tm1Tmj/Wnt5b^tm1Tmj	involves: 129S1/Sv * 129S7/SvEvBrd	MGI:4412398
cx9	Wnt4^tm1Amc/Wnt4⁺ Wnt5a^tm1Amc/Wnt5a^tm1Amc	involves: 129S1/Sv * 129S7/SvEvBrd	MGI:4412394
cx10	Sox7^tm1.1Dsco/Sox7⁺ Wnt4^{tm2(EGFP/cre/ERT2)Amc}/Wnt4⁺	involves: 129/Sv * 129S/SvEv * C57BL/6 * C57BL/6J	MGI:7543479

Allelic Composition	Wnt4^{em1(IMPC)Hmgu}/Wnt4⁺
Genetic Background	C57BL/6NCrl-Wnt4^{em1(IMPC)Hmgu}/Ieg

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt4^{em1(IMPC)Hmgu} mutation (1 available); any Wnt4 mutation (21 available)

Data Sources

IMPC Data for Wnt4

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased neutrophil cell number ( J:211773 )

IMPC - HMGU

thrombocytopenia ( J:211773 )

IMPC - HMGU

decreased lymphocyte cell number ( J:211773 )

IMPC - HMGU

increased monocyte cell number ( J:211773 )

IMPC - HMGU

homeostasis/metabolism

increased circulating bilirubin level ( J:211773 )

IMPC - HMGU

decreased circulating cholesterol level ( J:211773 )

IMPC - HMGU

decreased circulating HDL cholesterol level ( J:211773 )

IMPC - HMGU

increased circulating aspartate transaminase level ( J:211773 )

IMPC - HMGU

immune system

increased neutrophil cell number ( J:211773 )

IMPC - HMGU

decreased lymphocyte cell number ( J:211773 )

IMPC - HMGU

increased monocyte cell number ( J:211773 )

IMPC - HMGU

Allelic Composition	Wnt4^{tm2(EGFP/cre/ERT2)Amc}/Wnt4⁺
Genetic Background	involves: 129/Sv * 129S/SvEv * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt4^{tm2(EGFP/cre/ERT2)Amc} mutation (1 available); any Wnt4 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality during fetal growth through weaning, incomplete penetrance ( J:338879 )

• although present in normal ratios at E15.5/E16.5, heterozygotes are recovered at lower than Mendelian ratios at weaning; however, increase in lethality between E15.5/E16.5 and weaning does not reach statistical significance

cardiovascular system

cardiovascular system phenotype ( J:338879 )

N	• no ventricular septal defects were identified at E15.5

atrioventricular cushion hypoplasia ( J:338879 )

• at E10.5, atrioventricular (AV) endocardial cushions are hypocellular with a significant reduction in mesenchymal cell density relative to wild-type and single Sox7^tm1.1Dsco heterozygous controls

Allelic Composition	Hnf1b^tm1Sce/Hnf1b⁺ Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hnf1b^tm1Sce mutation (2 available); any Hnf1b mutation (16 available)
Wnt4^{tm2(EGFP/cre)Svo} mutation (1 available); any Wnt4 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:194051 )

N	• glomerular cysts and enlarged tubules are not seen, unlike in mice heterozygous for Hnf1b^tm1Ics and Wnt4^{tm2(EGFP/cre)Svo}

Allelic Composition	Hnf1b^tm1Ics/Hnf1b⁺ Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hnf1b^tm1Ics mutation (0 available); any Hnf1b mutation (16 available)
Wnt4^{tm2(EGFP/cre)Svo} mutation (1 available); any Wnt4 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal glomerulus cyst ( J:194051 )

• in some mice

abnormal renal tubule morphology ( J:194051 )

• enlarged, more obvious at E15.5 than at P0

growth/size/body

renal glomerulus cyst ( J:194051 )

• in some mice

Allelic Composition	Hnf1b^tm1Ics/Hnf1b^tm1Sce Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hnf1b^tm1Ics mutation (0 available); any Hnf1b mutation (16 available)
Hnf1b^tm1Sce mutation (2 available); any Hnf1b mutation (16 available)
Wnt4^{tm2(EGFP/cre)Svo} mutation (1 available); any Wnt4 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:194051 )

• die within the first 2 days after birth

renal/urinary system

abnormal kidney morphology ( J:194051 )

• higher density of mature glomeruli in the medulla region compared to the periphery unlike in controls

renal glomerulus cyst ( J:194051 )

• 12-16% of glomeruli become cystic

abnormal metanephros morphology ( J:194051 )

• expression analysis indicates a defect in proximal and intermediate regions of the S-shaped bodies development during tubule development

• S-shaped bodies appear less convoluted

• decrease in proliferation in comma-shaped bodies and a stronger decrease in the future proximal tubule of S-shaped bodies at E16.5

• increase in apoptosis in kidney epithelium but not stroma at E16.5

• strong increase in apoptosis in late mutant nephron tubules and a more moderate increase in S-shaped bodies

hydronephrosis ( J:194051 )

• occasional

abnormal renal tubule morphology ( J:194051 )

• decrease in tubular structures

• reduction of 43.5% in mature glomeruli mutant kidneys

• higher density of mature glomeruli in the medulla region compared to the periphery unlike in controls

abnormal loop of Henle morphology ( J:194051 )

• medullar elongated loop of Henle tubules are not visible at P0

abnormal proximal convoluted tubule morphology ( J:194051 )

• not visible at P0

growth/size/body

renal glomerulus cyst ( J:194051 )

• 12-16% of glomeruli become cystic

Allelic Composition	Dkk1^tm1.1Svo/Dkk1^tm1.2Svo Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1^tm1.1Svo mutation (1 available); any Dkk1 mutation (17 available)
Dkk1^tm1.2Svo mutation (0 available); any Dkk1 mutation (17 available)
Wnt4^{tm2(EGFP/cre)Svo} mutation (1 available); any Wnt4 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:173125 )

N	• mice exhibit normal kidneys

Allelic Composition	Tcf21^tm2.1Seq/Tcf21^tm1Jrt Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf21^tm1Jrt mutation (0 available); any Tcf21 mutation (16 available)
Tcf21^tm2.1Seq mutation (0 available); any Tcf21 mutation (16 available)
Wnt4^{tm2(EGFP/cre)Svo} mutation (1 available); any Wnt4 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal podocyte morphology ( J:217144 )

• defective foot process formation

• podocytes remain columnar at E18.5

abnormal renal glomerulus morphology ( J:217144 )

• glomeruli are primitive and reduced in size at E18.5

• complexity of glomerulus is reduced

small kidney ( J:217144 )

• slightly reduced in size but no overt abnormality in tubular formation

Allelic Composition	Wnt4^tm1Amc/Wnt4⁺ Wnt5a^tm1Amc/Wnt5a^tm1Amc Wnt5b^tm1Tmj/Wnt5b^tm1Tmj
Genetic Background	involves: 129S1/Sv * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt4^tm1Amc mutation (2 available); any Wnt4 mutation (21 available)
Wnt5a^tm1Amc mutation (1 available); any Wnt5a mutation (41 available)
Wnt5b^tm1Tmj mutation (0 available); any Wnt5b mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal motor neuron morphology ( J:155074 )

• at E13.5, median motor column motor neurons at the thoracic level are decreased 59% compared to in wild-type mice

• at E13.5, hypaxial motor column motor neurons at the thoracic level are increased 62% compared to in wild-type mice

limbs/digits/tail

abnormal limb morphology ( J:155074 )

Allelic Composition	Wnt4^tm1Amc/Wnt4⁺ Wnt5a^tm1Amc/Wnt5a^tm1Amc
Genetic Background	involves: 129S1/Sv * 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased motor neuron number ( J:155074 )

• at E13.5, median motor column motor neurons at the thoracic level are decreased 22% compared to in wild-type mice

limbs/digits/tail

abnormal limb morphology ( J:155074 )

Allelic Composition	Sox7^tm1.1Dsco/Sox7⁺ Wnt4^{tm2(EGFP/cre/ERT2)Amc}/Wnt4⁺
Genetic Background	involves: 129/Sv * 129S/SvEv * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox7^tm1.1Dsco mutation (0 available); any Sox7 mutation (19 available)
Wnt4^{tm2(EGFP/cre/ERT2)Amc} mutation (1 available); any Wnt4 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality during fetal growth through weaning, incomplete penetrance ( J:338879 )

• although present in normal ratios at E15.5/E16.5, double heterozygotes are recovered at lower than Mendelian ratios at weaning; however, increase in lethality between E15.5/E16.5 and weaning does not reach statistical significance

cardiovascular system

atrioventricular cushion hypoplasia ( J:338879 )

• at E10.5, atrioventricular (AV) endocardial cushions are hypocellular with a significant reduction in mesenchymal cell density relative to wild-type and single heterozygous controls

ventricular septal defect ( J:338879 )

• at E15.5, three of 8 (38%) of double heterozygotes develop VSDs, not observed in wild-type or single heterozygous controls

perimembraneous ventricular septal defect ( J:338879 )

• at E15.5, two of 8 double heterozygotes develop perimembranous VSDs

muscular ventricular septal defect ( J:338879 )

• at E15.5, one of 8 double heterozygotes shows a muscular VSD

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