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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tgfbr2+
wild type
MGI:2432216
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Tgfbr2tm1.1Hcd/Tgfbr2+ 129S6(Cg)-Tgfbr2tm1.1Hcd MGI:5543899
ht2
 		Tgfbr2em1(IMPC)Rbrc/Tgfbr2+ C57BL/6NJcl-Tgfbr2em1(IMPC)Rbrc/Rbrc MGI:7415116
ht3
 		Tgfbr2tm1Dgen/Tgfbr2+ involves: 129P2/OlaHsd MGI:3848614
ht4
 		Tgfbr2tm1Sjkm/Tgfbr2+ Not Specified MGI:3714274
cn5
 		Krastm4Tyj/Kras+
Tgfbr2tm1.2Hlm/Tgfbr2+
Ptf1atm1.1(cre)Cvw/Ptf1a+ 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2 MGI:3695569


Genotype
MGI:5543899
ht1
Allelic
Composition		 Tgfbr2tm1.1Hcd/Tgfbr2+
Genetic
Background		 129S6(Cg)-Tgfbr2tm1.1Hcd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgfbr2tm1.1Hcd mutation (1 available); any Tgfbr2 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal aorta elastic fiber morphology ( J:204960 )
• elastic fiber fragmentation is observed in aortic roots by 24 weeks of age
increased aorta wall thickness ( J:204960 )
• progressive thickening of aortic wall with excessive collagen deposition
abnormal aortic arch morphology ( J:204960 )
• elongation and tortuosity is found in the aortic arch and coronary arteries
abnormal aorta bulb morphology ( J:204960 )
• progressive enlargement of aortic root diameter beginning at 4 weeks of age
dilated aorta bulb ( J:204960 )
• aortic root aneurysm
ascending aorta aneurysm ( J:204960 )
• aortic root aneurysm
abnormal coronary artery morphology ( J:204960 )
• elongation and tortuosity is found in the aortic arch and coronary arteries
hemopericardium ( J:204960 )
• hemothorax or hemopericardium is observable in approximately 60% of deaths
hemothorax ( J:204960 )
• hemothorax or hemopericardium is observable in approximately 60% of deaths

mortality/aging
premature death ( J:204960 )
• 85% survival by 180 days

skeleton
kyphosis ( J:204960 )
• kyphosis is observed in 24 week old mice

homeostasis/metabolism
hemopericardium ( J:204960 )
• hemothorax or hemopericardium is observable in approximately 60% of deaths

respiratory system
hemothorax ( J:204960 )
• hemothorax or hemopericardium is observable in approximately 60% of deaths

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Loeys-Dietz syndrome DOID:0050466 J:204960




Genotype
MGI:7415116
ht2
Allelic
Composition		 Tgfbr2em1(IMPC)Rbrc/Tgfbr2+
Genetic
Background		 C57BL/6NJcl-Tgfbr2em1(IMPC)Rbrc/Rbrc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgfbr2em1(IMPC)Rbrc mutation (0 available); any Tgfbr2 mutation (39 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
enlarged heart ( J:211773 )
IMPC - RBRC

growth/size/body
enlarged heart ( J:211773 )
IMPC - RBRC
enlarged kidney ( J:211773 )
IMPC - RBRC

liver/biliary system
small liver ( J:211773 )
IMPC - RBRC

renal/urinary system
enlarged kidney ( J:211773 )
IMPC - RBRC




Genotype
MGI:3848614
ht3
Allelic
Composition		 Tgfbr2tm1Dgen/Tgfbr2+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgfbr2tm1Dgen mutation (0 available); any Tgfbr2 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
adipose tissue
increased total body fat amount ( J:148831 )
• males have a reduced fat/lean ratio (males show increased adiposity relative to females)
abnormal fat pad morphology ( J:148831 )
• males show a trend to decreased individual fat pad weights; females show the opposite (trend to higher fat pad weights relative to wild type)

homeostasis/metabolism
increased fatty acids level ( J:148831 )
• mice show significant increase in endpoint free fatty acids




Genotype
MGI:3714274
ht4
Allelic
Composition		 Tgfbr2tm1Sjkm/Tgfbr2+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgfbr2tm1Sjkm mutation (0 available); any Tgfbr2 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:71591 )
• treatment with diethylnitrosamine results in enhanced tumorigenesis (hepatic adenomas and carcinomas) in the liver compared to wild-type
• however, no increase in spontaneous liver tumor development is observed

liver/biliary system
increased hepatocyte proliferation ( J:71591 )
• proliferation index of hepatocytes is mildly increased compared to wild-type
• hepatocytes isolated from 15 day old, but not 9 month old, mutants are slightly less sensitive to the growth-inhibitory effect of Tgfb compared to wild-type

neoplasm
increased incidence of tumors by chemical induction ( J:71591 )
• treatment with diethylnitrosamine results in enhanced tumorigenesis (hepatic adenomas and carcinomas) in the liver compared to wild-type
• however, no increase in spontaneous liver tumor development is observed

cellular
increased hepatocyte proliferation ( J:71591 )
• proliferation index of hepatocytes is mildly increased compared to wild-type
• hepatocytes isolated from 15 day old, but not 9 month old, mutants are slightly less sensitive to the growth-inhibitory effect of Tgfb compared to wild-type




Genotype
MGI:3695569
cn5
Allelic
Composition		 Krastm4Tyj/Kras+
Tgfbr2tm1.2Hlm/Tgfbr2+
Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (11 available); any Kras mutation (68 available)
Ptf1atm1.1(cre)Cvw mutation (1 available); any Ptf1a mutation (29 available)
Tgfbr2tm1.2Hlm mutation (0 available); any Tgfbr2 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:116129 )
• exhibit reduced survival than controls after 200 days of age, with a median survival of 347 days

neoplasm
increased pancreas tumor incidence ( J:116129 )
• pancreatic tumors examined demonstrate a dominant sarcomatoid histology (50% or more) as well as the ductal adenocarcinoma
increased pancreatic ductal adenocarcinoma incidence ( J:116129 )
• at 200 days of age or later, show well-differentiated ductal adenocarcinoma in the pancreas head region
increased pancreatic intraepithelial neoplasia incidence ( J:116129 )
• develop pancreatic intraepithelial neoplasia (mPanIN) lesions predominantly in the pancreas tail region
increased metastatic potential ( J:116129 )
• tumors frequently show gross metastasis to the liver and lung, direct invasion to the duodenum, and also peritoneal dissemination
• frequency of metastasis or invasion is much higher (about 50%) than in similar mutants with homozygous, instead of heterozygous, loss of Tgfbr2

endocrine/exocrine glands
increased pancreas tumor incidence ( J:116129 )
• pancreatic tumors examined demonstrate a dominant sarcomatoid histology (50% or more) as well as the ductal adenocarcinoma
increased pancreatic ductal adenocarcinoma incidence ( J:116129 )
• at 200 days of age or later, show well-differentiated ductal adenocarcinoma in the pancreas head region
increased pancreatic intraepithelial neoplasia incidence ( J:116129 )
• develop pancreatic intraepithelial neoplasia (mPanIN) lesions predominantly in the pancreas tail region




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/24/2026
MGI 6.24 		The Jackson Laboratory