Analysis Tools|
Allele Symbol Allele Name Allele ID |
Rara+ wild type MGI:2431794 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 3 of 8 heterozygotes show ventral extension of the cricoid cartilage
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• 3 of 8 heterozygotes show ventral extension of the cricoid cartilage
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the number of Ki67-positive hepatocytes is 1.5-fold greater compared to age-matched control mice but 1.5 fold less than hepatocytes from homozygous mice conditionally null for Trim24 in the liver
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• the number of Ki67-positive hepatocytes is 1.5-fold greater compared to age-matched control mice but 1.5 fold less than hepatocytes from homozygous mice conditionally null for Trim24 in the liver
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• frequently fused to the incus, which is continuous with a rostrally oriented cartilaginous or osseous rod
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• continuous with a rostrally oriented cartilaginous or osseous rod, which is frequently fused with the alisphenoid bone
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• larger than in wild-type mice
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• bilateral absence of the epithelial rudiments of all intraorbital glands (including lachrymal and Harderian glands) in all mice at E18.5
• however, the stroma is present
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• continuous with a rostrally oriented cartilaginous or osseous rod, which is frequently fused with the alisphenoid bone
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• larger than in wild-type mice
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• severe in one mouse, milder in two mice
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• frequently fused to the incus, which is continuous with a rostrally oriented cartilaginous or osseous rod
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• continuous with a rostrally oriented cartilaginous or osseous rod, which is frequently fused with the alisphenoid bone
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• larger than in wild-type mice
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• severe in one mouse, milder in two mice
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• in all mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• abnormalities of the heart and abnormalities of the great vessels related to aortic arch patterning defects similar to those seen in offspring of vitamin A deficient rats were seen in these mice at E18.5
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• the right dorsal aortic root that is normally lost persists (2 out of 5)
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• the right 4th aortic arch that normally persists is lost (2 out of 5)
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• dextroposed ascending aorta - the aorta originates from the right ventricle (2 out of 5)
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• associated with dextroposition of the aorta, defects are also found in the membranous portion of the ventricular septum but not in the muscular portion of the septum (3 out of 5)
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• associated with the defect in aortic morphology the aortic valve has 4 cusps
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• the parathyroid glands were rostrally displaced and not associated with the thyroid gland
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• the kidneys are smaller than normal due to bilateral hypoplasia however division of the kidney into cortical and medullary regions is still present (2 out of 5)
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• multiple defects in the cartilages that make up the skeleton of, the trachea, the extrapulmonary bronchi, and the larynx were found at E18.5
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• the arytenoid cartilage is smaller than normal (11 out of 11)
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• the shape of the cricoid cartilage is abnormal (11 out of 11)
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• the cricoid cartilage is abnormally fused to the tracheal rings (11 out of 11)
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• the thyroid cartilage is smaller than normal (11 out of 11)
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• detailed examination revealed that the cartilages in the caudal portion of the stem bronchi are fused (11 out of 11)
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• the tracheal cartilage rings are absent and are replaced by ventral cartilage and cartilaginous nodules (11 out of 11)
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• the arytenoid cartilage is smaller than normal (11 out of 11)
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• the shape of the cricoid cartilage is abnormal (11 out of 11)
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• the cricoid cartilage is abnormally fused to the tracheal rings (11 out of 11)
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• the thyroid cartilage is smaller than normal (11 out of 11)
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• the tracheal cartilage rings are absent and are replaced by ventral cartilage and cartilaginous nodules (11 out of 11)
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• the right 4th aortic arch that normally persists is lost (2 out of 5)
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• the right 4th aortic arch that normally persists is lost (2 out of 5)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 9 of 15 (60%) of mutants exhibit skeletal abnormalities
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• 1 of 15 (7%) mutants show sternum malformations
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• 8 of 15 (53%) mutants show fusion of C1-AA with C2 dens
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• 2 of 15 (13%) mutants show a bifid C2
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• 1 of 15 (7%) mutants show posterior transformation of C7 to T1
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• there is about a 3-fold increase in the number of Ki67-positive hepatocytes in 14 week old mice
• this number of Ki67-positive hepatocytes 40% less than the number found in age-matched mice that are homozygous null for Trim24 but homozygous wild-type for Rara
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| N |
• no liver tumors are found in mice between 12 and 15 months of age compared to 70% liver tumor incidence in age-matched mice that are homozygous null for Trim24 but homozygous wild-type for Rara
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• there is about a 3-fold increase in the number of Ki67-positive hepatocytes in 14 week old mice
• this number of Ki67-positive hepatocytes 40% less than the number found in age-matched mice that are homozygous null for Trim24 but homozygous wild-type for Rara
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/18/2025 MGI 6.24 |
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