Analysis Tools|
Allele Symbol Allele Name Allele ID |
Ptgs1+ wild type MGI:2431749 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice fed a high fat and sucrose diet exhibit normal weight gain
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• fat pad tissue from mice fed a high fat and sucrose diet exhibit a 2-fold increase in prostaglandin production compared with tissues from similarly treated wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• heterozygous mutant peritoneal macrophages display a 70% reduction in basal PGE2 production relative to wild-type macrophages
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• levels of prostaglandin E2 are significantly lower in mammary glands of heterozygotes on day 4 of lactation compared to wild-type
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 50% in the epidermis
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• skin from UV-treated mice exhibits 20% less basal cell proliferation than in skin from similarly treated wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 79% of mice die within the first 48 hours of birth
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• 74% of mice that die within the first 48 hrs of birth exhibit patent ductus arteriosus
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• 74% of mice that die within the first 48 hrs of birth exhibit patent ductus arteriosus
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice survive 10 months unlike ApcMin heterozygotes that die after 7 to 8 months
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• mice form 43% fewer tumors than in ApcMin heterozygotes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/24/2026 MGI 6.24 |
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