Phenotypes associated with this allele

• Allele Symbol: Plg⁺
• Allele Name: wild type
• Allele ID: MGI:2431726
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Plg^tm1Jld/Plg^+	involves: 129P2/OlaHsd * C57BL/6J	MGI:3690643
ht2	Plg^tm1Dco/Plg^+	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3720817
ht3	Plg^tm1Dco/Plg^+	involves: 129S2/SvPas * C57BL/6J	MGI:3720868
cx4	Plg^tm1Jld/Plg^+ Tg(MSR1-Plau)1Ddi/0	B6.Cg-Plg^tm1Jld Tg(MSR1-Plau)1Ddi	MGI:3690232
cx5	Cpb2^tm1Efp/Cpb2^+ Plg^tm1Dco/Plg^+	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3720825
cx6	Cpb2^tm1Efp/Cpb2^tm1Efp Plg^tm1Dco/Plg^+	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3720826

Genotype
MGI:3690643

ht1

• Allelic Composition: Plg^tm1Jld/Plg⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased angiogenesis ( J:108675 )

• aortic vessel explants show almost complete lack of capillary sprouting in collagen lattices

Genotype
MGI:3720817

ht2

• Allelic Composition: Plg^tm1Dco/Plg⁺
• Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

homeostasis/metabolism

abnormal blood coagulation ( J:80114 )

• in an in vitro assay, an intermidiate level of fibrinolysis activity is observed (20.3%+/-1.5% lysis compared to 2.3%+/-1.1% in Plg^tm1Dco homozygotes and 47.6%+/-8.9% in wild-type extracts)

immune system

abnormal inflammatory response ( J:80114 )

• 72 hours following thioglycollate injection into the peritoneum, recruitment of leukocytes is intermediately compromised (15.0+/-1.3 x10⁶ leukocytes in the peritoneum compared to 9.34+/-0.43 x10⁶ in Plg^tm1Dco homozygotes and 28.7+/-1.62 x10⁶ in wild-type mice)

Genotype
MGI:3720868

ht3

• Allelic Composition: Plg^tm1Dco/Plg⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

homeostasis/metabolism

abnormal blood coagulation ( J:30174 )

• 24 hours fibrin clot lysis is reduced to 62+/-7% compare to 85+/-5% in wild-type mice and -2+/-1% in Plg^tm1Dco homozygotes

Genotype
MGI:3690232

cx4

• Allelic Composition: Plg^tm1Jld/Plg⁺; Tg(MSR1-Plau)1Ddi/0
• Genetic Background: B6.Cg-Plg^tm1Jld Tg(MSR1-Plau)1Ddi

cardiovascular system

abnormal heart morphology ( J:113474 )

• exhibit significantly less cardiac fibrosis than seen in single Tg(MSR1-Plau)1Ddi mutants and no increase in cardiac macrophage accumulation

Genotype
MGI:3720825

cx5

• Allelic Composition: Cpb2^tm1Efp/Cpb2⁺; Plg^tm1Dco/Plg⁺
• Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

homeostasis/metabolism

abnormal blood coagulation ( J:80114 )

• in an in vitro assay, fibrinolysis activity is increased relative to in Plg^tm1Dco homozygotes

immune system

abnormal inflammatory response ( J:80114 )

• 72 hours following thioglycollate injection into the peritoneum, recruitment of leukocytes is improved (23.8+/-2.1 x10⁶ leukocytes in the peritoneum compared to 15.0+/-1.3 x10⁶ in Plg^tm1Dco heterozygotes and 28.7+/-1.62 x10⁶ in wild-type mice)

Genotype
MGI:3720826

cx6

• Allelic Composition: Cpb2^tm1Efp/Cpb2^tm1Efp; Plg^tm1Dco/Plg⁺
• Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

homeostasis/metabolism

abnormal blood coagulation ( J:80114 )

• in an in vitro assay, fibrinolysis activity is increased relative to in Plg^tm1Dco homozygotes and in Cpb2^tm1Efp Plg^tm1Dco heterozygotes

immune system

abnormal inflammatory response ( J:80114 )

• 72 hours following thioglycollate injection into the peritoneum, recruitment of leukocytes is improved (29.5+/-2.7 x10⁶ leukocytes in the peritoneum compared to 15.0+/-1.3 x10⁶ in Plg^tm1Dco heterozygotes and 28.7+/-1.62 x10⁶ in wild-type mice)