All Phenotypes Nras<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nras⁺
wild type
MGI:2431642

Summary

19 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	\Nras^{tm1b(EUCOMM)Hmgu}/\Nras⁺	C57BL/6N-Nras^{tm1b(EUCOMM)Hmgu}/H	MGI:6263049
ht2	\Nras^tm1.1Emfu/\Nras⁺	involves: 129S1/Sv * FVB/N	MGI:5447946
cn3	\Nras^tm1Tyj/\Nras⁺ \Meox2^tm1(cre)Sor/\Meox2⁺	B6.Cg-Nras^tm1Tyj Meox2^tm1(cre)Sor	MGI:7544840
cn4	\Nras^tm1Tyj/\Nras⁺ \Tg(Tek-cre)1Ywa/0	B6.Cg-Nras^tm1Tyj Tg(Tek-cre)1Ywa	MGI:7544842
cn5	\Nras^tm1Tyj/\Nras⁺ \Tg(Tnnt2-cre)5Blh/0	B6.Cg-Nras^tm1Tyj Tg(Tnnt2-cre)5Blh	MGI:7544844
cn6	\Ezh2^tm1.1Nesh/\Ezh2⁺ \Nras^tm1.1Nesh/\Nras⁺ \Tg(Tyr-cre/ERT2)13Bos/0	involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB	MGI:6393932
cn7	\Cdkn2a^tm2.1Nesh/\Cdkn2a^tm2.1Nesh \Nras^tm1.1Nesh/\Nras⁺ \Tg(Tyr-cre/ERT2)13Bos/0	involves: 129 * 129S4/SvJae * 129P2/OlaHsd * C57BL/6 * FVB	MGI:6393936
cn8	\Cdkn2a^tm2.1Nesh/\Cdkn2a^tm2.1Nesh \Ezh2^tm1.1Nesh/\Ezh2⁺ \Nras^tm1.1Nesh/\Nras⁺ \Tg(Tyr-cre/ERT2)13Bos/0	involves: 129 * 129S4/SvJae * 129P2/OlaHsd * C57BL/6 * FVB	MGI:6393935
cn9	\Nras^tm1Tyj/\Nras⁺ \Meox2^tm1(cre)Sor/\Meox2⁺	involves: 129S4/SvJaeSor * C57BL/6	MGI:5284833
cn10	\Nras^tm1Tyj/\Nras⁺ \Tg(Tyr-cre/ERT2)1Lru/0	involves: C57BL/6 * DBA/2	MGI:5755095
cn11	\Nras^tm1Tyj/\Nras⁺ \Tg(Vil1-cre)20Syr/0	involves: C57BL/6 * DBA/2	MGI:3776027
cn12	\Nras^tm1Tyj/\Nras⁺ \Tg(Tyr-cre)1Lru/0	involves: C57BL/6 * DBA/2	MGI:5755101
cn13	\Nras^tm1Tyj/\Nras⁺ \Tg(Fabp1-cre)1Jig/0	involves: C57BL/6 * FVB/N	MGI:3776024
cx14	\Kras^tm1Mok/\Kras⁺ \Nras^tm1Mok/\Nras⁺	B6.129S-Nras^tm1Mok Kras^tm1Mok	MGI:4821324
cx15	\Hras^tm1Mok/\Hras^tm1Mok \Kras^tm1Mok/\Kras⁺ \Nras^tm1Mok/\Nras⁺ \Tg(HRAS)2Jic/0	involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2	MGI:4821330
cx16	\Hras^tm1Mok/\Hras^tm1Mok \Nras^tm1Mok/\Nras⁺	involves: 129S/SvEv * C57BL/6 * DBA/2	MGI:4821328
cx17	\Hras^tm1Mok/\Hras^tm1Mok \Kras^tm1Mok/\Kras⁺ \Nras^tm1Mok/\Nras⁺	involves: 129S/SvEv * C57BL/6 * DBA/2	MGI:4821329
cx18	\Kras^tm1Mok/\Kras⁺ \Nras^tm1Mok/\Nras⁺	involves: 129S/SvEv * C57BL/6 * DBA/2	MGI:4821323
cx19	\Kras^tm1Tyj/\Kras^tm1Tyj \Nras^tm1Rak/\Nras⁺	involves: 129/Sv * C57BL/6	MGI:3589358

Allelic Composition	\Nras^{tm1b(EUCOMM)Hmgu}/\Nras⁺
Genetic Background	C57BL/6N-Nras^{tm1b(EUCOMM)Hmgu}/H
Cell Lines	HEPD0719_5_C04

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nras^{tm1b(EUCOMM)Hmgu} mutation (0 available); any Nras mutation (42 available)

Data Sources

IMPC Data for Nras

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating glucose level ( J:211773 )

IMPC - HAR

increased circulating HDL cholesterol level ( J:211773 )

IMPC - HAR

limbs/digits/tail

short tibia ( J:211773 )

IMPC - HAR

skeleton

short tibia ( J:211773 )

IMPC - HAR

Allelic Composition	\Nras^tm1.1Emfu/\Nras⁺
Genetic Background	involves: 129S1/Sv * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nras^tm1.1Emfu mutation (0 available); any Nras mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:189834 )

• transient reduction in body weight in some mice, which is compensated before adulthood

Allelic Composition	\Nras^tm1Tyj/\Nras⁺ \Meox2^tm1(cre)Sor/\Meox2⁺
Genetic Background	B6.Cg-Nras^tm1Tyj Meox2^tm1(cre)Sor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2^tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Nras^tm1Tyj mutation (1 available); any Nras mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:305401 )

• embryos are recovered at normal numbers at E12.5-E14.5; however, all embryos die between E15.5 and E17.5

growth/size/body

decreased fetal size ( J:305401 )

• at E15.5, embryos are smaller than control embryos

• however, embryos are grossly normal at E13.5

integument

pallor ( J:305401 )

• embryos exhibit pale bodies at E15.5

homeostasis/metabolism

hydrops fetalis ( J:305401 )

• at E15.5, embryos display whole-body edema

cardiovascular system

abnormal heart morphology ( J:305401 )

• starting at E13.5, hearts show morphological defects that resemble congenital cardiac defects seen in Noonan syndrome patients

myocardial hypertrabeculation ( J:305401 )

• at E13.5, hearts exhibit myocardial hypertrabeculation

thin ventricle myocardium compact layer ( J:305401 )

• at E13.5, the compact layer thickness in the right and left heart ventricle is reduced by 62.5 and 45.5%, respectively

thin myocardium ( J:305401 )

• at E13.5, 4 of 6 hearts exhibit a thin myocardium

abnormal heart development ( J:305401 )

• at E13.5, hearts exhibit downregulated non-canonical Wnt and BMP pathways and hyperactivated MEK/ERK signaling, indicating dysregulation of critical pathways involved in heart development

• however, no alterations in cell proliferation or apoptosis are observed in the heart at E13.5

abnormal pulmonary valve development ( J:305401 )

• pulmonary valves are not remodeled properly

double outlet right ventricle ( J:305401 )

• at E13.5, 4 of 6 hearts exhibit a DORV phenotype, where both the aorta and pulmonary trunk exit the right ventricle

ventricular septal defect ( J:305401 )

• at E13.5, all (6 of 6) hearts show ventricular septal defects (VSDs); the interventricular septum fails to fuse with the endocardial cushion, unlike in control hearts

pulmonary valve stenosis ( J:305401 )

• at E13.5, 4 of 6 hearts exhibit pulmonary valve stenosis

thin ventricular wall ( J:305401 )

liver/biliary system

small liver ( J:305401 )

• fetal livers are smaller at E15.5

hepatic necrosis ( J:305401 )

• at E15.5, hepatic necrosis is observed, esp. in the regions distal from blood flow

hematopoietic system

abnormal definitive hematopoiesis ( J:305401 )

• fetal liver hematopoiesis is mildly perturbed at E13.5

increased erythroid progenitor cell number ( J:305401 )

• at E13.5, fetal livers show a moderate expansion of Ter119- CD71^mid/hi cells that are enriched with colony forming unit-erythroid (CFU-E) progenitors and early erythroblasts

• however, the % of terminally differentiating Ter119+ erythroid cells is similar to that of controls

increased hematopoietic stem cell number ( J:305401 )

• at E13.5, embryos show a moderate expansion of hematopoietic stem and progenitor cells in the fetal liver

abnormal fetal liver hematopoietic progenitor cell morphology ( J:305401 )

• at E13.5, embryos show a moderate expansion of hematopoietic stem and progenitor cells in the fetal liver; both HSCs (defined as Lin- Mac1+ CD41- CD48- CD150+ Sca1+ cKit+) and LSK cells (hematopoietic stem and progenitor cells, defined as Lin- Sca1+ cKit+) are expanded

muscle

myocardial hypertrabeculation ( J:305401 )

• at E13.5, hearts exhibit myocardial hypertrabeculation

thin ventricle myocardium compact layer ( J:305401 )

• at E13.5, the compact layer thickness in the right and left heart ventricle is reduced by 62.5 and 45.5%, respectively

thin myocardium ( J:305401 )

• at E13.5, 4 of 6 hearts exhibit a thin myocardium

Allelic Composition	\Nras^tm1Tyj/\Nras⁺ \Tg(Tek-cre)1Ywa/0
Genetic Background	B6.Cg-Nras^tm1Tyj Tg(Tek-cre)1Ywa

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nras^tm1Tyj mutation (1 available); any Nras mutation (42 available)
Tg(Tek-cre)1Ywa mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:305401 )

• live embryos are recovered at normal numbers at E14.5; however, all embryos die by E17.5

cardiovascular system

myocardial hypertrabeculation ( J:305401 )

• at E13.5, three of 5 hearts exhibit myocardial hypertrabeculation

thin ventricle myocardium compact layer ( J:305401 )

• at E13.5, three of 5 hearts exhibit a thin compact layer with a deeply invaginated trabecular layer

double outlet right ventricle ( J:305401 )

• at E13.5, two of 5 hearts exhibit DORV

ventricular septal defect ( J:305401 )

• at E13.5, two of 5 hearts show ventricular septal defects (VSDs)

pulmonary valve stenosis ( J:305401 )

• at E13.5, two of 5 hearts exhibit pulmonary valve stenosis

muscle

myocardial hypertrabeculation ( J:305401 )

• at E13.5, three of 5 hearts exhibit myocardial hypertrabeculation

thin ventricle myocardium compact layer ( J:305401 )

• at E13.5, three of 5 hearts exhibit a thin compact layer with a deeply invaginated trabecular layer

Allelic Composition	\Nras^tm1Tyj/\Nras⁺ \Tg(Tnnt2-cre)5Blh/0
Genetic Background	B6.Cg-Nras^tm1Tyj Tg(Tnnt2-cre)5Blh

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nras^tm1Tyj mutation (1 available); any Nras mutation (42 available)
Tg(Tnnt2-cre)5Blh mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:305401 )

N	• mice exhibit normal viability during embryonic development

cardiovascular system

cardiovascular system phenotype ( J:305401 )

N	• mice do NOT exhibit any gross cardiac malformations during embryonic development

Allelic Composition	\Ezh2^tm1.1Nesh/\Ezh2⁺ \Nras^tm1.1Nesh/\Nras⁺ \Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background	involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ezh2^tm1.1Nesh mutation (1 available); any Ezh2 mutation (70 available)
Nras^tm1.1Nesh mutation (2 available); any Nras mutation (42 available)
Tg(Tyr-cre/ERT2)13Bos mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:239472 )

N	• tamoxifen-treated mice do not show acceleration of melanomagenesis and do not form melanoma compared to single Nras conditional mutants

Allelic Composition	\Cdkn2a^tm2.1Nesh/\Cdkn2a^tm2.1Nesh \Nras^tm1.1Nesh/\Nras⁺ \Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background	involves: 129 * 129S4/SvJae * 129P2/OlaHsd * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm2.1Nesh mutation (4 available); any Cdkn2a mutation (66 available)
Nras^tm1.1Nesh mutation (2 available); any Nras mutation (42 available)
Tg(Tyr-cre/ERT2)13Bos mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased melanoma incidence ( J:239472 )

• tamoxifen-treated mice develop melanoma

Allelic Composition	\Cdkn2a^tm2.1Nesh/\Cdkn2a^tm2.1Nesh \Ezh2^tm1.1Nesh/\Ezh2⁺ \Nras^tm1.1Nesh/\Nras⁺ \Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background	involves: 129 * 129S4/SvJae * 129P2/OlaHsd * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm2.1Nesh mutation (4 available); any Cdkn2a mutation (66 available)
Ezh2^tm1.1Nesh mutation (1 available); any Ezh2 mutation (70 available)
Nras^tm1.1Nesh mutation (2 available); any Nras mutation (42 available)
Tg(Tyr-cre/ERT2)13Bos mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased melanoma incidence ( J:239472 )

• tamoxifen-treated mice develop melanoma similarly to conditional Nras and Cdkn2a double mutants

Allelic Composition	\Nras^tm1Tyj/\Nras⁺ \Meox2^tm1(cre)Sor/\Meox2⁺
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:174880 )

• no mice born alive

Allelic Composition	\Nras^tm1Tyj/\Nras⁺ \Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nras^tm1Tyj mutation (1 available); any Nras mutation (42 available)
Tg(Tyr-cre/ERT2)1Lru mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal skin morphology ( J:198244 )

• mice painted with tamoxifen on to shaven back skin develop small paucicelluar nevi in the deep dermal and periadnexal regions of the skin

pigmentation

hyperpigmentation ( J:198244 )

• 50% of mice painted with tamoxifen on to shaven back skin at about 2 months of age exhibit weak darkening of the skin within 4 to 8 months

Allelic Composition	\Nras^tm1Tyj/\Nras⁺ \Tg(Vil1-cre)20Syr/0
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nras^tm1Tyj mutation (1 available); any Nras mutation (42 available)
Tg(Vil1-cre)20Syr mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:132357 )

• one week after exposure to 2.5% dextran sodium sulfate (DSS), colonic epithelium shows high resistance to the effects relative to wild-type and Kras mutant animals; sensitivity to DSS-induced apoptosis is strongly reduced

Allelic Composition	\Nras^tm1Tyj/\Nras⁺ \Tg(Tyr-cre)1Lru/0
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nras^tm1Tyj mutation (1 available); any Nras mutation (42 available)
Tg(Tyr-cre)1Lru mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal behavior ( J:198244 )

• progress to akathisia and general malaise

hyperresponsive to tactile stimuli ( J:198244 )

• at a median age of 12.5 months

tremors ( J:198244 )

• seen at a median age of 12.5 months

impaired coordination ( J:198244 )

• mice exhibit incoordination at a median age of 12.5 months

abnormal gait ( J:198244 )

• mice show impaired gait at a median age of 12.5 months

skeleton

abnormal cranium morphology ( J:198244 )

• most mice develop increasing cranial perimeter or cranial deformity symptoms

mortality/aging

premature death ( J:198244 )

• mice begin to die around 6 months of age with about 25% surviving past 18 months of age

craniofacial

abnormal cranium morphology ( J:198244 )

• most mice develop increasing cranial perimeter or cranial deformity symptoms

pigmentation

hyperpigmentation ( J:198244 )

• darkening of the skin, tails, paws, and snouts that is evident from day 1 and persists throughout life, that is less pronounced than that in homozygotes

Allelic Composition	\Nras^tm1Tyj/\Nras⁺ \Tg(Fabp1-cre)1Jig/0
Genetic Background	involves: C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nras^tm1Tyj mutation (1 available); any Nras mutation (42 available)
Tg(Fabp1-cre)1Jig mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:132357 )

N	• expression of mutant Nras appears to have no effect on the histology of the colonic epithelium

Allelic Composition	\Kras^tm1Mok/\Kras⁺ \Nras^tm1Mok/\Nras⁺
Genetic Background	B6.129S-Nras^tm1Mok Kras^tm1Mok

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm1Mok mutation (6 available); any Kras mutation (88 available)
Nras^tm1Mok mutation (7 available); any Nras mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

chylous ascites ( J:159024 )

• 19 of 26 mice develop chylous ascites unlike wild-type mice

Allelic Composition	\Hras^tm1Mok/\Hras^tm1Mok \Kras^tm1Mok/\Kras⁺ \Nras^tm1Mok/\Nras⁺ \Tg(HRAS)2Jic/0
Genetic Background	involves: 129S/SvEv * BALB/c * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hras^tm1Mok mutation (15 available); any Hras mutation (30 available)
Kras^tm1Mok mutation (6 available); any Kras mutation (88 available)
Nras^tm1Mok mutation (7 available); any Nras mutation (42 available)
Tg(HRAS)2Jic mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:159024 )

N	• no mice exhibit chylous ascites

Allelic Composition	\Hras^tm1Mok/\Hras^tm1Mok \Nras^tm1Mok/\Nras⁺
Genetic Background	involves: 129S/SvEv * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hras^tm1Mok mutation (15 available); any Hras mutation (30 available)
Nras^tm1Mok mutation (7 available); any Nras mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

chylous ascites ( J:159024 )

• 2 of 175 mice develop chylous ascites unlike wild-type mice

Allelic Composition	\Hras^tm1Mok/\Hras^tm1Mok \Kras^tm1Mok/\Kras⁺ \Nras^tm1Mok/\Nras⁺
Genetic Background	involves: 129S/SvEv * C57BL/6 * DBA/2

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

chylous ascites ( J:159024 )

• 35 of 37 mice develop chylous ascites unlike wild-type mice

Allelic Composition	\Kras^tm1Mok/\Kras⁺ \Nras^tm1Mok/\Nras⁺
Genetic Background	involves: 129S/SvEv * C57BL/6 * DBA/2

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

chylous ascites ( J:159024 )

• 5 of 76 mice develop chylous ascites unlike wild-type mice

immune system

abnormal lymphatic vessel morphology ( J:159024 )

• in the small intestine

Allelic Composition	\Kras^tm1Tyj/\Kras^tm1Tyj \Nras^tm1Rak/\Nras⁺
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm1Tyj mutation (1 available); any Kras mutation (88 available)
Nras^tm1Rak mutation (1 available); any Nras mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, incomplete penetrance ( J:43433 )

• ~40% of mutant embryos are found dead at E9.5

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