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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nfkb1+
wild type
MGI:2431597
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Nfkb1M1Btlr/Nfkb1+ C57BL/6J-Nfkb1M1Btlr MGI:5608895
ht2
 		Nfkb1m2Btlr/Nfkb1+ C57BL/6J-Nfkb1m2Btlr MGI:6113390
ht3
 		Nfkb1M3Btlr/Nfkb1+ C57BL/6J-Nfkb1M3Btlr MGI:6113384


Genotype
MGI:5608895
ht1
Allelic
Composition		 Nfkb1M1Btlr/Nfkb1+
Genetic
Background		 C57BL/6J-Nfkb1M1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb1M1Btlr mutation (1 available); any Nfkb1 mutation (104 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased IgG level ( J:216054 )
• mice bearing this mutation exhibit a reduced T cell dependent IgG response at day 28 following immunization at days 0 and 14 with recombinant Semliki virus- (rSV-) encoded beta-galactosidase; the response of heterozygous mutant mice is intermediate between those of wild-type and homozygous mutant animals.

immune system
decreased IgG level ( J:216054 )
• mice bearing this mutation exhibit a reduced T cell dependent IgG response at day 28 following immunization at days 0 and 14 with recombinant Semliki virus- (rSV-) encoded beta-galactosidase; the response of heterozygous mutant mice is intermediate between those of wild-type and homozygous mutant animals.
impaired humoral immune response ( J:216054 )
• mice bearing this mutation exhibit a reduced T cell dependent IgG response at day 28 following immunization at days 0 and 14 with recombinant Semliki virus- (rSV-) encoded beta-galactosidase; the response of heterozygous mutant mice is intermediate between those of wild-type and homozygous mutant animals.




Genotype
MGI:6113390
ht2
Allelic
Composition		 Nfkb1m2Btlr/Nfkb1+
Genetic
Background		 C57BL/6J-Nfkb1m2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb1m2Btlr mutation (0 available); any Nfkb1 mutation (104 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased IgM level ( J:254822 )
• decreased TNP-specific IgM to TNP-Ficoll immunization

immune system
abnormal humoral immune response ( J:254822 )
• decreased TNP-specific IgM to TNP-Ficoll immunization
decreased IgM level ( J:254822 )
• decreased TNP-specific IgM to TNP-Ficoll immunization




Genotype
MGI:6113384
ht3
Allelic
Composition		 Nfkb1M3Btlr/Nfkb1+
Genetic
Background		 C57BL/6J-Nfkb1M3Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkb1M3Btlr mutation (0 available); any Nfkb1 mutation (104 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal humoral immune response ( J:254821 )
• decreased antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)
decreased IgG level ( J:254821 )
• decreased antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)

hematopoietic system
decreased IgG level ( J:254821 )
• decreased antibody response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase (rSFV-beta-gal)




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory