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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Myod1+
wild type
MGI:2431577
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		\Krastm4Tyj/\Kras+
\Myod1tm1.1(cre/ERT,TVA)Gcg/\Myod1+
\Trp53tm1Brn/\Trp53tm1Brn 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:5547939
cn2
 		\Abl1tm1Gcos/\Abl1+
\Myf5tm2Tajb/\Myf5tm2Tajb
\Myf6tm1Tajb/\Myf6tm1Tajb
\Myod1tm2.1(icre)Glh/\Myod1+ 		involves: 129S * 129X1/SvJ * C57BL/6J MGI:4939891
cn3
 		\Acvr1tm1Glh/\Acvr1+
\Myod1tm2.1(icre)Glh/\Myod1+ 		involves: 129S6/SvEvTac * C57BL/6J * FVB/N MGI:7278769
cx4
 		\Myf5tm1Pas/\Myf5tm1Pas
\Myod1tm1Jae/\Myod1+ 		involves: 129 * C57BL/6 * DBA/2 MGI:3055414
cx5
 		\Myf6tm1Eno/\Myf6tm1Eno
\Myod1tm1Jae/\Myod1+
\Myogtm1Whk/\Myog+ 		involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 MGI:3714517
cx6
 		\Myf5tm1Jae/\Myf5tm1Jae
\Myod1tm1.1Glh/\Myod1+ 		involves: 129/Sv * 129S4/SvJae * C57BL/6J MGI:3840224


Genotype
MGI:5547939
cn1
Allelic
Composition		 \Krastm4Tyj/\Kras+
\Myod1tm1.1(cre/ERT,TVA)Gcg/\Myod1+
\Trp53tm1Brn/\Trp53tm1Brn
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (12 available); any Kras mutation (88 available)
Myod1tm1.1(cre/ERT,TVA)Gcg mutation (1 available); any Myod1 mutation (24 available)
Trp53tm1Brn mutation (21 available); any Trp53 mutation (249 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:205518 )
• when mice older than 6 weeks are given systemic tamoxifen treatment by intraperitoneal delivery, mice develop multiple tumors at clinically relevant sites with a median tumor free survival of 153 days (longer latency than Pax7CE mutants
increased sarcoma incidence ( J:205518 )
• tamoxifen treated mice develop sarcomas that are exclusively undifferentiated pleomorphic sarcomas (UPS), myogenic or nonmyogenic in type
• tumors can appear in the body wall, the extremities, or the head and neck region




Genotype
MGI:4939891
cn2
Allelic
Composition		 \Abl1tm1Gcos/\Abl1+
\Myf5tm2Tajb/\Myf5tm2Tajb
\Myf6tm1Tajb/\Myf6tm1Tajb
\Myod1tm2.1(icre)Glh/\Myod1+
Genetic
Background		 involves: 129S * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abl1tm1Gcos mutation (0 available); any Abl1 mutation (91 available)
Myf5tm2Tajb mutation (0 available); any Myf5 mutation (17 available)
Myf6tm1Tajb mutation (0 available); any Myf6 mutation (19 available)
Myod1tm2.1(icre)Glh mutation (1 available); any Myod1 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
abnormal myogenesis ( J:168843 )
• skeletal myogenesis is not suppressed by genotoxins unlike in wild-type mice

homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:168843 )
• skeletal myogenesis is not suppressed by genotoxins unlike in wild-type mice




Genotype
MGI:7278769
cn3
Allelic
Composition		 \Acvr1tm1Glh/\Acvr1+
\Myod1tm2.1(icre)Glh/\Myod1+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr1tm1Glh mutation (0 available); any Acvr1 mutation (43 available)
Myod1tm2.1(icre)Glh mutation (1 available); any Myod1 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:257905 )
N
• pinch or cardiotoxin-mediated injury of the gastrocnemius or tibialis anterior hindlimb muscles of adults does not cause heterotopic ossification




Genotype
MGI:3055414
cx4
Allelic
Composition		 \Myf5tm1Pas/\Myf5tm1Pas
\Myod1tm1Jae/\Myod1+
Genetic
Background		 involves: 129 * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5tm1Pas mutation (1 available); any Myf5 mutation (17 available)
Myod1tm1Jae mutation (2 available); any Myod1 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3714517
cx5
Allelic
Composition		 \Myf6tm1Eno/\Myf6tm1Eno
\Myod1tm1Jae/\Myod1+
\Myogtm1Whk/\Myog+
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf6tm1Eno mutation (0 available); any Myf6 mutation (19 available)
Myod1tm1Jae mutation (2 available); any Myod1 mutation (24 available)
Myogtm1Whk mutation (0 available); any Myog mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:48809 )
• mutants are normal, viable and fertile and appear to have normal muscle




Genotype
MGI:3840224
cx6
Allelic
Composition		 \Myf5tm1Jae/\Myf5tm1Jae
\Myod1tm1.1Glh/\Myod1+
Genetic
Background		 involves: 129/Sv * 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5tm1Jae mutation (1 available); any Myf5 mutation (17 available)
Myod1tm1.1Glh mutation (0 available); any Myod1 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
abnormal muscle development ( J:87370 )
• trunk musculature is disorganized compared to in wild-type mice
• expression of Myod1 is delayed at E10.5 compared to in wild-type mice
• however, the Pax3-mediated recovery of Myod1 is normal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory