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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Msx1+
wild type
MGI:2431473
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Msx1tm1b(KOMP)Wtsi/Msx1+ C57BL/6N-Msx1tm1b(KOMP)Wtsi/J MGI:5759340
cn2
 		Isl1tm1(cre)Sev/Isl1+
Msx1tm1Rilm/Msx1+
Pax9tm1Rbal/Pax9tm1.1Hpt 		involves: 129 * CD-1 MGI:7294564
cx3
 		Msx1tm1Rilm/Msx1+
Pax9tm1Rbal/Pax9tm1Rbal 		involves: 129 * CD-1 MGI:7294559
cx4
 		Msx1tm1Rilm/Msx1+
Pax9tm1Rbal/Pax9+ 		involves: 129 * CD-1 MGI:7294560
cx5
 		Barx1tm1Shiv/Barx1tm1Shiv
Msx1tm1Bero/Msx1+ 		involves: 129P2/OlaHsd * various MGI:5307914
cx6
 		Msx1tm1Rilm/Msx1+
Msx2tm1Rilm/Msx2tm1Rilm 		involves: 129S4/SvJae * CD-1 MGI:3050863


Genotype
MGI:5759340
ht1
Allelic
Composition		 Msx1tm1b(KOMP)Wtsi/Msx1+
Genetic
Background		 C57BL/6N-Msx1tm1b(KOMP)Wtsi/J
Cell Lines EPD0334_7_D05
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1tm1b(KOMP)Wtsi mutation (1 available); any Msx1 mutation (19 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological

cardiovascular system

growth/size/body
increased heart weight ( J:211773 )
IMPC - JAX

homeostasis/metabolism




Genotype
MGI:7294564
cn2
Allelic
Composition		 Isl1tm1(cre)Sev/Isl1+
Msx1tm1Rilm/Msx1+
Pax9tm1Rbal/Pax9tm1.1Hpt
Genetic
Background		 involves: 129 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1tm1(cre)Sev mutation (1 available); any Isl1 mutation (38 available)
Msx1tm1Rilm mutation (1 available); any Msx1 mutation (19 available)
Pax9tm1.1Hpt mutation (2 available); any Pax9 mutation (21 available)
Pax9tm1Rbal mutation (0 available); any Pax9 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

skeleton
abnormal hyoid bone morphology ( J:311535 )
• ossification center is shorter
• angle between the greater and lesser horns is reduced

craniofacial
craniofacial phenotype ( J:311535 )
• unlike in germline null mice, cleft palate is not seen
abnormal hyoid bone morphology ( J:311535 )
• ossification center is shorter
• angle between the greater and lesser horns is reduced

limbs/digits/tail

cardiovascular system
aberrant origin of the right subclavian artery ( J:311535 )
• cervical origin in 2 of 8 neonates

respiratory system

growth/size/body
abnormal hyoid bone morphology ( J:311535 )
• ossification center is shorter
• angle between the greater and lesser horns is reduced
abnormal hyoid bone greater horn morphology ( J:311535 )
• reduced in length
abnormal hyoid bone lesser horn morphology ( J:311535 )
• extends laterally




Genotype
MGI:7294559
cx3
Allelic
Composition		 Msx1tm1Rilm/Msx1+
Pax9tm1Rbal/Pax9tm1Rbal
Genetic
Background		 involves: 129 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1tm1Rilm mutation (1 available); any Msx1 mutation (19 available)
Pax9tm1Rbal mutation (0 available); any Pax9 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

digestive/alimentary system

nervous system
decreased neural crest cell number ( J:311535 )
• decrease in the number of neural crest cells in the 4th pharyngeal arches at E10.5

cardiovascular system
abnormal first pharyngeal arch artery morphology ( J:311535 )
• abnormally persistent at E12.5
abnormal fourth pharyngeal arch artery morphology ( J:311535 )
• unlike in homozygous mice wild-type for Msx1 the arch is maintained in 7 of 12 embryos at E12.5
fourth pharyngeal arch artery hypoplasia ( J:311535 )
• at E10.5
• decrease in the number of neural crest cells at E10.5
abnormal second pharyngeal arch artery morphology ( J:311535 )
• abnormally persistent at E12.5
abnormal third pharyngeal arch artery morphology ( J:311535 )
• unlike in homozygous mice wild-type for Msx1 the arch is maintained in 8 of 12 embryos at E12.5
• unlike in homozygous mice wild-type for Msx1 smooth muscle cell recruitment is not reduced
third pharyngeal arch artery hypoplasia ( J:311535 )
• at E9.5 but not at E10.5
abnormal aorta morphology ( J:311535 )
• cervical origin of the aorta is increased compared to homozygous mice wild-type for Msx1
aberrant origin of the right subclavian artery ( J:311535 )
• significant reduction in retro-esophageal right subclavian artery and a significant increase in cervical origin compared to homozygous mice wild-type for Msx1
interrupted aortic arch ( J:311535 )
• significant reduction in the incidence of IAA-B compared to homozygous mice wild-type for Msx1
abnormal common carotid artery morphology ( J:311535 )
• reduction in the incidence of absent common carotid arteries compared to homozygous mice wild-type for Msx1 (24% compared to 57%)
double outlet right ventricle ( J:311535 )
• only seen in a single mouse

endocrine/exocrine glands
thymus hypoplasia ( J:311535 )
• severely hypoplastic and absent from the normal position
ectopic thymus ( J:311535 )
• severely hypoplastic and absent from the normal position

craniofacial
abnormal first pharyngeal arch artery morphology ( J:311535 )
• abnormally persistent at E12.5
abnormal fourth pharyngeal arch artery morphology ( J:311535 )
• unlike in homozygous mice wild-type for Msx1 the arch is maintained in 7 of 12 embryos at E12.5
fourth pharyngeal arch artery hypoplasia ( J:311535 )
• at E10.5
• decrease in the number of neural crest cells at E10.5
abnormal second pharyngeal arch artery morphology ( J:311535 )
• abnormally persistent at E12.5
abnormal third pharyngeal arch artery morphology ( J:311535 )
• unlike in homozygous mice wild-type for Msx1 the arch is maintained in 8 of 12 embryos at E12.5
• unlike in homozygous mice wild-type for Msx1 smooth muscle cell recruitment is not reduced
third pharyngeal arch artery hypoplasia ( J:311535 )
• at E9.5 but not at E10.5

embryo
abnormal first pharyngeal arch artery morphology ( J:311535 )
• abnormally persistent at E12.5
abnormal fourth pharyngeal arch artery morphology ( J:311535 )
• unlike in homozygous mice wild-type for Msx1 the arch is maintained in 7 of 12 embryos at E12.5
fourth pharyngeal arch artery hypoplasia ( J:311535 )
• at E10.5
• decrease in the number of neural crest cells at E10.5
abnormal second pharyngeal arch artery morphology ( J:311535 )
• abnormally persistent at E12.5
abnormal third pharyngeal arch artery morphology ( J:311535 )
• unlike in homozygous mice wild-type for Msx1 the arch is maintained in 8 of 12 embryos at E12.5
• unlike in homozygous mice wild-type for Msx1 smooth muscle cell recruitment is not reduced
third pharyngeal arch artery hypoplasia ( J:311535 )
• at E9.5 but not at E10.5
decreased neural crest cell number ( J:311535 )
• decrease in the number of neural crest cells in the 4th pharyngeal arches at E10.5

growth/size/body
cleft secondary palate ( J:311535 )

hematopoietic system
thymus hypoplasia ( J:311535 )
• severely hypoplastic and absent from the normal position
ectopic thymus ( J:311535 )
• severely hypoplastic and absent from the normal position

immune system
thymus hypoplasia ( J:311535 )
• severely hypoplastic and absent from the normal position
ectopic thymus ( J:311535 )
• severely hypoplastic and absent from the normal position

limbs/digits/tail




Genotype
MGI:7294560
cx4
Allelic
Composition		 Msx1tm1Rilm/Msx1+
Pax9tm1Rbal/Pax9+
Genetic
Background		 involves: 129 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1tm1Rilm mutation (1 available); any Msx1 mutation (19 available)
Pax9tm1Rbal mutation (0 available); any Pax9 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
decreased tooth number ( J:311535 )
• absence of lower teeth

growth/size/body
decreased tooth number ( J:311535 )
• absence of lower teeth

skeleton
decreased tooth number ( J:311535 )
• absence of lower teeth




Genotype
MGI:5307914
cx5
Allelic
Composition		 Barx1tm1Shiv/Barx1tm1Shiv
Msx1tm1Bero/Msx1+
Genetic
Background		 involves: 129P2/OlaHsd * various
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Barx1tm1Shiv mutation (0 available); any Barx1 mutation (6 available)
Msx1tm1Bero mutation (1 available); any Msx1 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
arrest of tooth development ( J:180393 )
• permanent in molars at the bud stage

growth/size/body
arrest of tooth development ( J:180393 )
• permanent in molars at the bud stage

skeleton
arrest of tooth development ( J:180393 )
• permanent in molars at the bud stage




Genotype
MGI:3050863
cx6
Allelic
Composition		 Msx1tm1Rilm/Msx1+
Msx2tm1Rilm/Msx2tm1Rilm
Genetic
Background		 involves: 129S4/SvJae * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msx1tm1Rilm mutation (1 available); any Msx1 mutation (19 available)
Msx2tm1Rilm mutation (1 available); any Msx2 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:83306 )
N
• compound mutants display normal development of the malleus in the middle ear




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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory