Phenotypes associated with this allele

• Allele Symbol: Itgb3⁺
• Allele Name: wild type
• Allele ID: MGI:2431261
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Itgb3^tm1Hyn/Itgb3^+	involves: 129S2/SvPas * C57BL/6	MGI:4439371
cx2	Fbn1^tm2.1Hcd/Fbn1^+ Itgb3^tm1Hyn/Itgb3^+	involves: 129S * 129X1/SvJ * C57BL/6J * FVB/N	MGI:5558881
cx3	Fbn1^tm3.1Hcd/Fbn1^+ Itgb3^tm1Hyn/Itgb3^+	involves: 129S * 129X1/SvJ * C57BL/6J * FVB/N	MGI:5558883
cx4	Ilk^tm2Star/Ilk^+ Itgb3^tm1Hyn/Itgb3^+	involves: 129S2/SvPas * C57BL/6	MGI:5502226

Genotype
MGI:4439371

ht1

• Allelic Composition: Itgb3^tm1Hyn/Itgb3⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased heart weight ( J:119666 )

• heart weight to body weight ratio is increased

cardiac hypertrophy ( J:119666 )

• the hypertrophy phenotype is intermediate between homozygous null and wild-type mice

heart left ventricle hypertrophy ( J:119666 )

• spontaneous

increased heart left ventricle weight ( J:119666 )

• left ventricle weight to body weight ratio is increased

decreased heart rate ( J:119666 )

• heart rate is significantly decreased 7 days after pressure overload by transverse aortic constriction surgery (TAC) compared to wild-type

increased response of heart to induced stress ( J:119666 )

• impairment of systolic and diastolic function after transverse aortic constriction is more severe than in wild-type controls

• heart rate is significantly decreased 7 days after pressure overload by transverse aortic constriction surgery (TAC) compared to wild-type

homeostasis/metabolism

increased response of heart to induced stress ( J:119666 )

• impairment of systolic and diastolic function after transverse aortic constriction is more severe than in wild-type controls

• heart rate is significantly decreased 7 days after pressure overload by transverse aortic constriction surgery (TAC) compared to wild-type

growth/size/body

increased heart weight ( J:119666 )

• heart weight to body weight ratio is increased

cardiac hypertrophy ( J:119666 )

• the hypertrophy phenotype is intermediate between homozygous null and wild-type mice

heart left ventricle hypertrophy ( J:119666 )

• spontaneous

muscle

heart left ventricle hypertrophy ( J:119666 )

• spontaneous

Genotype
MGI:5558881

cx2

• Allelic Composition: Fbn1^tm2.1Hcd/Fbn1⁺; Itgb3^tm1Hyn/Itgb3⁺
• Genetic Background: involves: 129S * 129X1/SvJ * C57BL/6J * FVB/N

integument

integument phenotype ( J:206074 )

N • skin stiffness and collagen deposition are normalized at 3 months

abnormal cutaneous collagen fibril morphology ( J:206074 )

• increased collagen in the dermis of some mice at 5 months as in Itgb3-deficient mice

thick dermal layer ( J:206074 )

• in some mice at 5 months as in Itgb3-deficient mice

epidermal hyperplasia ( J:206074 )

• focal in some mice at 5 months as in Itgb3-deficient mice

Genotype
MGI:5558883

cx3

• Allelic Composition: Fbn1^tm3.1Hcd/Fbn1⁺; Itgb3^tm1Hyn/Itgb3⁺
• Genetic Background: involves: 129S * 129X1/SvJ * C57BL/6J * FVB/N

integument

integument phenotype ( J:206074 )

N • skin stiffness and collagen deposition are normalized at 3 months

abnormal cutaneous collagen fibril morphology ( J:206074 )

• increased collagen in the dermis of some mice at 5 months as in Itgb3-deficient mice

thick dermal layer ( J:206074 )

• in some mice at 5 months as in Itgb3-deficient mice

epidermal hyperplasia ( J:206074 )

• focal in some mice at 5 months as in Itgb3-deficient mice

Genotype
MGI:5502226

cx4

• Allelic Composition: Ilk^tm2Star/Ilk⁺; Itgb3^tm1Hyn/Itgb3⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6

skeleton

increased trabecular bone thickness ( J:197593 )

• mice display significant increase in thickness of the trabeculae at the primary spongiosa