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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nrg1+
wild type
MGI:2431005
Summary 11 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Nrg1tm1Gne/Nrg1+ B6.129S2-Nrg1tm1Gne MGI:5318195
ht2
 		Nrg1m1Yzcm/Nrg1+ C57BL/6J-Nrg1m1Yzcm MGI:5285957
ht3
 		Nrg1tm1Lwr/Nrg1+ involves: 129 MGI:3530782
ht4
 		Nrg1tm1Cbm/Nrg1+ involves: 129P2/OlaHsd MGI:3530781
ht5
 		Nrg1tm2Cbm/Nrg1+ involves: 129P2/OlaHsd MGI:3835557
ht6
 		Nrg1tm4.1Cbm/Nrg1+ involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 MGI:5524257
ht7
 		Nrg1tm1Leth/Nrg1+ involves: 129S1/Sv * C57BL/6 MGI:3530661
ht8
 		Nrg1tm2Zhou/Nrg1+ involves: 129S4/SvJae * C57BL/6 MGI:3530450
cx9
 		Erbb2tm1Cbm/Erbb2+
Erbb3tm2Cbm/Erbb3+
Nrg1tm1Cbm/Nrg1+ 		involves: 129P2/OlaHsd MGI:3530779
cx10
 		Erbb2tm1Cbm/Erbb2+
Nrg1tm1Cbm/Nrg1+ 		involves: 129P2/OlaHsd MGI:3530776
cx11
 		Bace1tm1Psa/Bace1tm1Psa
Nrg1tm4.1Cbm/Nrg1+ 		involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ * C57BL/6 MGI:5524258


Genotype
MGI:5318195
ht1
Allelic
Composition		 Nrg1tm1Gne/Nrg1+
Genetic
Background		 B6.129S2-Nrg1tm1Gne
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrg1tm1Gne mutation (0 available); any Nrg1 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal excitatory postsynaptic currents ( J:182690 )
• EPSCs remain elevated following theta-pulse stimulation (TPS) and slowly run down whereas in wild-type slices, LTP reversal is triggered by TPS
enhanced long-term potentiation ( J:182690 )
• significantly increased compared to controls (EPSC amplitude 322% vs 157%)
• after LTP induction, extended period of enhanced LTP is followed by a period of decreasing LTP




Genotype
MGI:5285957
ht2
Allelic
Composition		 Nrg1m1Yzcm/Nrg1+
Genetic
Background		 C57BL/6J-Nrg1m1Yzcm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrg1m1Yzcm mutation (0 available); any Nrg1 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Dilated pupils in Nrg1m1Yzcm/Nrg1+ and Nrg1m1Yzcm/Nrg1m1Yzcm mice

vision/eye
mydriasis ( J:175524 )
• 3 of 115 mice exhibit unilateral pupil dilation unlike wild-type mice
• 5 of 111 mice exhibit unilateral or partially dilated pupils unlike wild-type mice




Genotype
MGI:3530782
ht3
Allelic
Composition		 Nrg1tm1Lwr/Nrg1+
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrg1tm1Lwr mutation (0 available); any Nrg1 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal myelination ( J:90038 )
• thin myelin sheath observed on the sciatic nerve




Genotype
MGI:3530781
ht4
Allelic
Composition		 Nrg1tm1Cbm/Nrg1+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrg1tm1Cbm mutation (0 available); any Nrg1 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to xenobiotic induced morbidity/mortality ( J:100313 )
• 15 days after doxorubicin treatment to induce cardiac injury, survival is significantly lower in homozygotes (15%) than wild-type (33%)

nervous system
abnormal myelination ( J:90038 )
• hypomyelination; thin myelin sheath of sciatic nerve observed at P10 and at 6 months of age
• more pronounced for large caliber axons than small caliber axons
abnormal nerve conduction ( J:90038 )
• reduced nerve conduction velocity measured in the sciatic nerve, but with normal current amplitudes and muscle compound action potentials

cardiovascular system
decreased heart weight ( J:100313 )
• 4 days after doxorubicin treatment, homozygotes show a significant decrease in heart (29% loss) and left ventricle (27% loss) weight compared to wild-type (15% for heart and 13% for left ventricle)
abnormal cardiovascular system physiology ( J:100313 )
• exhibit more severe doxorubicin-induced cardiotoxicity than wild-type, with lower left ventricular systolic pressure and left ventricular midwall fractional shortening
decreased heart left ventricle muscle contractility ( J:100313 )
• doxorubicin-induced cardiac injury causes a higher reduction in left ventricular systolic pressure than in wild-type
• doxorubicin-induced cardiac injury causes a higher reduction in left ventricular midwall fractional shortening than in wild-type

growth/size/body
weight loss ( J:100313 )
• 4 days after doxorubicin treatment, homozygotes show an increase in the loss of body weight (27%) compared to wild-type (11%)

muscle
decreased heart left ventricle muscle contractility ( J:100313 )
• doxorubicin-induced cardiac injury causes a higher reduction in left ventricular systolic pressure than in wild-type
• doxorubicin-induced cardiac injury causes a higher reduction in left ventricular midwall fractional shortening than in wild-type

homeostasis/metabolism
increased susceptibility to xenobiotic induced morbidity/mortality ( J:100313 )
• 15 days after doxorubicin treatment to induce cardiac injury, survival is significantly lower in homozygotes (15%) than wild-type (33%)




Genotype
MGI:3835557
ht5
Allelic
Composition		 Nrg1tm2Cbm/Nrg1+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrg1tm2Cbm mutation (0 available); any Nrg1 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:145464 )
N
• thickness of the myelin sheath in the central nervous system is normal




Genotype
MGI:5524257
ht6
Allelic
Composition		 Nrg1tm4.1Cbm/Nrg1+
Genetic
Background		 involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrg1tm4.1Cbm mutation (0 available); any Nrg1 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle

nervous system




Genotype
MGI:3530661
ht7
Allelic
Composition		 Nrg1tm1Leth/Nrg1+
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrg1tm1Leth mutation (0 available); any Nrg1 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuromuscular synapse morphology ( J:39800 )
• a 51% reduction in the density of acetylcholine receptors on the postsynaptic membrane was observed by [125-I] bungarotoxin staining
• no increase in size of the endplate was observed
abnormal PNS synaptic transmission ( J:39800 )
• neuromuscular synapse transmission was more sensitive to curare in heterozygotes than controls
• repetitive nerve stimulation stimulated compound muscle action potentials in heterozygous mice similar to controls, but lower doses of curare were required to decrease the amplitude compared to controls
abnormal endplate potential ( J:39800 )
• the mean evoked end plate potenital was not reduced in heterozygotes, although quantal size is reduced; compensatory mechanisms appear to increase the number of quanta released per pulse
• evoked end plate potentials decay more rapidly at heterozygous endplates than at controls
abnormal miniature endplate potential ( J:39800 )
• the mean spontaneous miniature endplate potentials were reduced by approximately 30% in heterozygous mice




Genotype
MGI:3530450
ht8
Allelic
Composition		 Nrg1tm2Zhou/Nrg1+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrg1tm2Zhou mutation (0 available); any Nrg1 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
hyperactivity ( J:81106 )
• animals are significantly more active than controls in an open field test and in a four arm-cross maze test
• treatment of mice with 1mg/kg clozapine reversed the phenotype

nervous system
abnormal prepulse inhibition ( J:81106 )
• impairment was seen, while normal acoustic startle response was also observed

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
schizophrenia DOID:5419 OMIM:181500
 J:81106




Genotype
MGI:3530779
cx9
Allelic
Composition		 Erbb2tm1Cbm/Erbb2+
Erbb3tm2Cbm/Erbb3+
Nrg1tm1Cbm/Nrg1+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2tm1Cbm mutation (0 available); any Erbb2 mutation (59 available)
Erbb3tm2Cbm mutation (0 available); any Erbb3 mutation (46 available)
Nrg1tm1Cbm mutation (0 available); any Nrg1 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal myelination ( J:90038 )
• hypomyelination; thin myelin sheath of sciatic nerve observed at P10 and at 6 months of age
abnormal nerve conduction ( J:90038 )
• reduced nerve conduction velocity measured in the sciatic nerve, but with normal current amplitudes and muscle compound action potentials




Genotype
MGI:3530776
cx10
Allelic
Composition		 Erbb2tm1Cbm/Erbb2+
Nrg1tm1Cbm/Nrg1+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2tm1Cbm mutation (0 available); any Erbb2 mutation (59 available)
Nrg1tm1Cbm mutation (0 available); any Nrg1 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal myelination ( J:90038 )
• hypomyelination; thin myelin sheath of sciatic nerve observed at P10 and at 6 months of age
abnormal nerve conduction ( J:90038 )
• reduced nerve conduction velocity measured in the sciatic nerve, but with normal current amplitudes and muscle compound action potentials




Genotype
MGI:5524258
cx11
Allelic
Composition		 Bace1tm1Psa/Bace1tm1Psa
Nrg1tm4.1Cbm/Nrg1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bace1tm1Psa mutation (0 available); any Bace1 mutation (29 available)
Nrg1tm4.1Cbm mutation (0 available); any Nrg1 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
abnormal muscle spindle morphology ( J:199150 )
• large diameter and high intrafusal fiber numbers
• however, outer capsule morphology and innervation
decreased muscle spindle number ( J:199150 )
• more pronounced in Nrg1tm4.1Cbm homozygotes

nervous system
abnormal muscle spindle morphology ( J:199150 )
• large diameter and high intrafusal fiber numbers
• however, outer capsule morphology and innervation
decreased muscle spindle number ( J:199150 )
• more pronounced in Nrg1tm4.1Cbm homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory