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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hbegf+
wild type
MGI:2430998
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Hbegftm1.1Mek/Hbegf+ B6.Cg-Hbegftm1.1Mek MGI:4818457
ht2
 		Hbegftm4Mek/Hbegf+ B6.Cg-Hbegftm4Mek MGI:4818455
ht3
 		Hbegftm3Mek/Hbegf+ involves: 129/Sv * C57BL/6 * CBA MGI:2683024
ht4
 		Hbegftm1.1Mek/Hbegf+ involves: C57BL/6 * C57BL/6J * CBA MGI:3785448


Genotype
MGI:4818457
ht1
Allelic
Composition		 Hbegftm1.1Mek/Hbegf+
Genetic
Background		 B6.Cg-Hbegftm1.1Mek
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbegftm1.1Mek mutation (2 available); any Hbegf mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal cardiovascular system physiology ( J:161948 )
• mesenchyme cells from cushion explants exhibit increased proliferation compared with similarly treated wild-type explants
• however, proliferation of endocardial cells from cushion explants is normal




Genotype
MGI:4818455
ht2
Allelic
Composition		 Hbegftm4Mek/Hbegf+
Genetic
Background		 B6.Cg-Hbegftm4Mek
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbegftm4Mek mutation (0 available); any Hbegf mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal cardiovascular system physiology ( J:161948 )
• proliferation of mesenchyme and endocardial cells from cushion explants in culture is increased compared to wild-type explants




Genotype
MGI:2683024
ht3
Allelic
Composition		 Hbegftm3Mek/Hbegf+
Genetic
Background		 involves: 129/Sv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbegftm3Mek mutation (0 available); any Hbegf mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, incomplete penetrance ( J:86547 )
• most chimerics displayed perinatal lethality
• survivors were fertile
• F1 heterozygotes (derived from chimerics) also showed perinatal lethality

cardiovascular system
abnormal myocardial fiber morphology ( J:86547 )
• cardiac muscle fibers are loose with large nuclei
• possibly reduced differentiation or terminated proliferation
cardiac hypertrophy ( J:86547 )
• ventricular hypertrophy seen at E16.5 and at birth

growth/size/body
cardiac hypertrophy ( J:86547 )
• ventricular hypertrophy seen at E16.5 and at birth
decreased body size ( J:86547 )
• chimerics with abnormally small bodies
• F1 phenotype even more severe

muscle
abnormal myocardial fiber morphology ( J:86547 )
• cardiac muscle fibers are loose with large nuclei
• possibly reduced differentiation or terminated proliferation

integument
thick epidermis ( J:86547 )
• chimerics have thickened skin
• F1 mice with elephant like skin
• skin transplanted to Balb/c nu/nu mice showed severe hyperplasia and large hair follicle-like structures




Genotype
MGI:3785448
ht4
Allelic
Composition		 Hbegftm1.1Mek/Hbegf+
Genetic
Background		 involves: C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbegftm1.1Mek mutation (2 available); any Hbegf mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:82728 )
• heterozygotes display no overt abnormalities




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/28/2024
MGI 6.13 		The Jackson Laboratory