Hbegf^tm1.1Mek
Targeted Allele Detail

Summary

• Symbol: Hbegf^tm1.1Mek
• Name: heparin-binding EGF-like growth factor; targeted mutation 1.1, Eisuke Mekada
• MGI ID: MGI:2655703
• Synonyms: HB^del, Hbegf^-
• Gene: Hbegf Location: Chr18:36637980-36648858 bp, - strand Genetic Position: Chr18, 19.46 cM
• Alliance: Hbegf^tm1.1Mek page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82728
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The loxP-flanked, wild-type Hbegf cDNA was excised from Hbegf^tm1Mek via Cre-mediated recombination in progeny of a cross between mice with the floxed allele and mice bearing a ubiquitously expressed cre transgene. The bacterial beta-galactosidase gene (lacZ) and the Pgk-neo cassette remain in place of most of exon 1 through exon 3 and most of the third intron of the native gene. Expression of lacZ is driven by the endogenous promoter; the beta-galactosidase protein is localized to the nucleus. (J:82728)

Expression

In Mice Carrying this Mutation:	41 assay results
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Hbegf Mutation: 25 strains or lines available

References

• Original: J:82728 Iwamoto R, et al., Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function. Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3221-6
• All: 8 reference(s)