Hbegf^tm4Mek
Targeted Allele Detail

Summary

• Symbol: Hbegf^tm4Mek
• Name: heparin-binding EGF-like growth factor; targeted mutation 4, Eisuke Mekada
• MGI ID: MGI:4818437
• Synonyms: HBdelta^hb
• Gene: Hbegf Location: Chr18:36637980-36648858 bp, - strand Genetic Position: Chr18, 19.46 cM
• Alliance: Hbegf^tm4Mek page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161948
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 through 3 were replaced with a cDNA of the corresponding sequence lacking the heparin-binding domain between Lys93 and Arg105. An IRES, neo cassette, and polyadenylation sequence were inserted downstream of the cDNA. (J:161948)

Expression

In Mice Carrying this Mutation:

3 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hbegf Mutation: 25 strains or lines available

References

• Original: J:161948 Iwamoto R, et al., HB-EGF function in cardiac valve development requires interaction with heparan sulfate proteoglycans. Development. 2010 Jul;137(13):2205-14
• All: 1 reference(s)