All Phenotypes Htr1b<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Htr1b⁺
wild type
MGI:2430969

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Htr1b^{tm1.1(KOMP)Vlcg}/Htr1b⁺	C57BL/6N-Htr1b^{tm1.1(KOMP)Vlcg}/J	MGI:5631210
ht2	Htr1b^tm1Rhn/Htr1b⁺	involves: 129S2/SvPas	MGI:3837411
cn3	Htr1b^tm1Rhn/Htr1b⁺ Tph1^tm1Kry/Tph1⁺ Tg(Vil1-cre)20Syr/0	involves: 129S2/SvPas * C57BL/6 * DBA/2	MGI:3837413
cx4	Htr1b^tm1Rhn/Htr1b⁺ Lrp5^tm1Kry/Lrp5^tm1Kry	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ	MGI:3837416

Allelic Composition	Htr1b^{tm1.1(KOMP)Vlcg}/Htr1b⁺
Genetic Background	C57BL/6N-Htr1b^{tm1.1(KOMP)Vlcg}/J
Cell Lines	13007A-F5

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr1b^{tm1.1(KOMP)Vlcg} mutation (1 available); any Htr1b mutation (26 available)

Data Sources

IMPC Data for Htr1b

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

decreased total body fat amount ( J:211773 )

IMPC - JAX

behavior/neurological

decreased grip strength ( J:211773 )

IMPC - JAX

hyperactivity ( J:211773 )

IMPC - JAX

cardiovascular system

increased heart weight ( J:211773 )

IMPC - JAX

growth/size/body

increased heart weight ( J:211773 )

IMPC - JAX

increased lean body mass ( J:211773 )

IMPC - JAX

Allelic Composition	Htr1b^tm1Rhn/Htr1b⁺
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr1b^tm1Rhn mutation (3 available); any Htr1b mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

increased osteoblast cell number ( J:146078 )

• at 1 and 3 months of age

increased bone mass ( J:146078 )

• at 1 and 3 months of age

increased bone ossification ( J:146078 )

• increased bone formation at 1 and 3 months of age

Allelic Composition	Htr1b^tm1Rhn/Htr1b⁺ Tph1^tm1Kry/Tph1⁺ Tg(Vil1-cre)20Syr/0
Genetic Background	involves: 129S2/SvPas * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr1b^tm1Rhn mutation (3 available); any Htr1b mutation (26 available)
Tg(Vil1-cre)20Syr mutation (4 available)
Tph1^tm1Kry mutation (0 available); any Tph1 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

increased bone mass ( J:146078 )

• phenotype is the same as in mice homozygous null for Htr1b and mice conditional null for Tph1 in the gut

Allelic Composition	Htr1b^tm1Rhn/Htr1b⁺ Lrp5^tm1Kry/Lrp5^tm1Kry
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr1b^tm1Rhn mutation (3 available); any Htr1b mutation (26 available)
Lrp5^tm1Kry mutation (0 available); any Lrp5 mutation (83 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:146078 )

N	• loss of expression of 1 copy of Htrb1 rescues the bone phenotype seen in Lrp5 null mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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