All Phenotypes Dcc<+> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Dcc^{tm1b(NCOM)Mfgc}/Dcc⁺	C57BL/6N-Dcc^{tm1b(NCOM)Mfgc}/Tcp	MGI:5797466
ht2	Dcc^tm1Wbg/Dcc⁺	involves: 129S2/SvPas * C57BL/6	MGI:2446652
ht3	Dcc^{Tg(H2-Kb-Jak2*V617F)1Shmd}/Dcc⁺	involves: C57BL/6 * DBA/2	MGI:5444033
cx4	Dcc^tm1Wbg/Dcc⁺ Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c⁺	involves: 129X1/SvJ * C57BL/6J * SJL/J	MGI:3665461
cx5	Dcc^tm1Wbg/Dcc⁺ Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c^{rcmTg(Ucp)1.23Kz}	involves: 129X1/SvJ * C57BL/6J * SJL/J	MGI:3665460
cx6	Apc^Min/Apc⁺ Dcc^tm1Wbg/Dcc⁺	involves: C57BL/6J	MGI:2446655

Allelic Composition	Dcc^{tm1b(NCOM)Mfgc}/Dcc⁺
Genetic Background	C57BL/6N-Dcc^{tm1b(NCOM)Mfgc}/Tcp
Cell Lines	M00044_C_385W_G11

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dcc^{tm1b(NCOM)Mfgc} mutation (1 available); any Dcc mutation (76 available)

Data Sources

IMPC Data for Dcc

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased neutrophil cell number ( J:211773 )

IMPC - TCP

immune system

increased neutrophil cell number ( J:211773 )

IMPC - TCP

Allelic Composition	Dcc^tm1Wbg/Dcc⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dcc^tm1Wbg mutation (1 available); any Dcc mutation (76 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:39765 )

N	• no significant increase in tumor predisposition was noted in heterozygous mice when compared to controls

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal definitive hematopoiesis ( J:130189 )

• increase in number of CD41+ cells and Gr-1/Mac1 double-positive cells in the bone marrow and spleen

• decrease in the percentage of B220+ B cells in the bone marrow and spleen

myeloid hyperplasia ( J:130189 )

• increase in numbers of mature myeloid cells in spleen

increased bone marrow cell number ( J:130189 )

• femurs exhibit hypercellular bone marrow with maturing myeloid cells, erythrocytes in many stages of differentiation, and mature megakaryocytes

abnormal megakaryocyte morphology ( J:130189 )

• megakaryocytes in the spleen are large in size and have multilobulated nuclei

increased megakaryocyte cell number ( J:130189 )

• increase in the number of megakaryocytes in the bone marrow

decreased erythroid progenitor cell number ( J:130189 )

• decrease in the percentage of erythroid precursor cells in the bone marrow

increased erythroblast number ( J:130189 )

• increase in the percentage of erythroblasts in spleen

polycythemia ( J:130189 )

• 8 of 43 mutants show polycythemia at 3 months of age

decreased hematocrit ( J:130189 )

abnormal neutrophil morphology ( J:130189 )

• increase in the percentage of neutrophil precursor cells in the bone marrow

thrombocytosis ( J:130189 )

• 15 of 43 mutants exhibit thrombocytosis

increased leukocyte cell number ( J:130189 )

• 15 of 43 mutants exhibit leukocytosis, with a predominance of granulocytes

• 2 of 8 mutants with polycythemia and 9 of 15 mutants with thromobocytosis exhibit leukocytosis

increased granulocyte number ( J:130189 )

• granulocytosis after 4 months of age

abnormal spleen morphology ( J:130189 )

• architecture of spleen is barely preserved

enlarged spleen ( J:130189 )

• splenomegaly is seen at 3-5 months of age in some mutants

• mutants with splenomegaly show at least one of the following: erythrocytosis, thrombocytosis, or leukocytosis

increased spleen weight ( J:130189 )

increased spleen red pulp amount ( J:130189 )

• red pulp is expanded due to invasion by non-lymphoid cells, megakaryocytes, erythroblasts, and maturing myeloid cells

decreased spleen white pulp amount ( J:130189 )

enhanced megakaryocyte emperipolesis ( J:130189 )

• emperipolesis of neutrophils in megakaryocyte cytoplasm is seen in the femurs; this is rarely observed in wild-type mice

immune system

myeloid hyperplasia ( J:130189 )

• increase in numbers of mature myeloid cells in spleen

abnormal neutrophil morphology ( J:130189 )

• increase in the percentage of neutrophil precursor cells in the bone marrow

increased leukocyte cell number ( J:130189 )

• 15 of 43 mutants exhibit leukocytosis, with a predominance of granulocytes

• 2 of 8 mutants with polycythemia and 9 of 15 mutants with thromobocytosis exhibit leukocytosis

increased granulocyte number ( J:130189 )

• granulocytosis after 4 months of age

abnormal spleen morphology ( J:130189 )

• architecture of spleen is barely preserved

enlarged spleen ( J:130189 )

• splenomegaly is seen at 3-5 months of age in some mutants

• mutants with splenomegaly show at least one of the following: erythrocytosis, thrombocytosis, or leukocytosis

increased spleen weight ( J:130189 )

increased spleen red pulp amount ( J:130189 )

• red pulp is expanded due to invasion by non-lymphoid cells, megakaryocytes, erythroblasts, and maturing myeloid cells

decreased spleen white pulp amount ( J:130189 )

growth/size/body

enlarged spleen ( J:130189 )

• splenomegaly is seen at 3-5 months of age in some mutants

• mutants with splenomegaly show at least one of the following: erythrocytosis, thrombocytosis, or leukocytosis

increased spleen weight ( J:130189 )

Mouse Models of Human Disease	DO ID	OMIM ID(s)	Ref(s)
essential thrombocythemia	DOID:2224	OMIM:187950 OMIM:601977 OMIM:614521	J:130189
polycythemia vera	DOID:8997	OMIM:263300	J:130189

Allelic Composition	Dcc^tm1Wbg/Dcc⁺ Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c⁺
Genetic Background	involves: 129X1/SvJ * C57BL/6J * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dcc^tm1Wbg mutation (1 available); any Dcc mutation (76 available)
Unc5c^{rcmTg(Ucp)1.23Kz} mutation (0 available); any Unc5c mutation (61 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon guidance ( J:80430 )

• a few axons fail to cross the midline at the pyramidal decussation and instead extend into the ventral funiculus of the cervical spinal cord

cellular

abnormal axon guidance ( J:80430 )

• a few axons fail to cross the midline at the pyramidal decussation and instead extend into the ventral funiculus of the cervical spinal cord

Allelic Composition	Dcc^tm1Wbg/Dcc⁺ Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c^{rcmTg(Ucp)1.23Kz}
Genetic Background	involves: 129X1/SvJ * C57BL/6J * SJL/J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon guidance ( J:80430 )

• some axons fail to cross the midline at the pyramidal decussation and instead extend into the lateral and ventral funiculus

cellular

abnormal axon guidance ( J:80430 )

• some axons fail to cross the midline at the pyramidal decussation and instead extend into the lateral and ventral funiculus

Allelic Composition	Apc^Min/Apc⁺ Dcc^tm1Wbg/Dcc⁺
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (156 available)
Dcc^tm1Wbg mutation (1 available); any Dcc mutation (76 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased intestinal adenoma incidence ( J:39765 )

• heterozygosity for the Dcc allele did not affect the polyp initiation or average size or morphology of the adenomas that occur in the Apc^Min heterozygous mice

digestive/alimentary system

increased intestinal adenoma incidence ( J:39765 )

• heterozygosity for the Dcc allele did not affect the polyp initiation or average size or morphology of the adenomas that occur in the Apc^Min heterozygous mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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