All Phenotypes Dbx1<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dbx1⁺
wild type
MGI:2430389

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Dbx1^tm1(DTA)Apie/Dbx1⁺ Pax7^tm1(cre)Mrc/Pax7⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4837354
cn2	Dbx1^tm2(cre)Apie/Dbx1⁺ Robo3^tm1.1Ache/Robo3^tm1.1Ache	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:4837353
cn3	Dbx1^tm1(DTA)Apie/Dbx1⁺ Tg(Nes-cre)1Kln/0	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:3770261

Allelic Composition	Dbx1^tm1(DTA)Apie/Dbx1⁺ Pax7^tm1(cre)Mrc/Pax7⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dbx1^tm1(DTA)Apie mutation (1 available); any Dbx1 mutation (21 available)
Pax7^tm1(cre)Mrc mutation (2 available); any Pax7 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:165285 )

N	• at E15.5, rhythmic activity in the pre-Botzinger complex is preserved

Allelic Composition	Dbx1^tm2(cre)Apie/Dbx1⁺ Robo3^tm1.1Ache/Robo3^tm1.1Ache
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dbx1^tm2(cre)Apie mutation (1 available); any Dbx1 mutation (21 available)
Robo3^tm1.1Ache mutation (0 available); any Robo3 mutation (76 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:165285 )

• mice do not survive after birth

nervous system

abnormal medulla oblongata morphology ( J:165285 )

• mice exhibit reduced biocytin stained commissural interneurons in the pre-Botzinger complex compared with wild-type mice

abnormal pre-Botzinger complex morphology ( J:165285 )

• mice exhibit reduced biocytin stained commissural interneurons in the pre-Botzinger complex compared with wild-type mice

abnormal pre-Botzinger complex physiology ( J:165285 )

• mice exhibit de-synchronization of rhythmic activity in the left and right pre-Botzinger complex compared with wild-type mice

Allelic Composition	Dbx1^tm1(DTA)Apie/Dbx1⁺ Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dbx1^tm1(DTA)Apie mutation (1 available); any Dbx1 mutation (21 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebral cortex morphology ( J:101434 )

• differences in cortical cytoarchitecture were observed in both rostral and caudal level

• the mutant cortex did not show a typical Reeler phenotype

abnormal olfactory cortex morphology ( J:101434 )

• strong decrease to a complete loss of Reelin expressing cells in the rostrocaudal axis of the telencephalic vesicles and of the olfactory bulb at E11.5 and E12.5

• no significant differences in Reelin expression in cortex of the wild-type and mutant at E14.5

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