Phenotypes associated with this allele

• Allele Symbol: Crhr1⁺
• Allele Name: wild type
• Allele ID: MGI:2430294
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Crhr1^tm1Wrst/Crhr1^+	either: (involves: 129P2/OlaHsd * 129P/Ola) or (involves: 129P2/OlaHsd * CD-1)	MGI:3037192
cx2	Crhr1^tm1Klee/Crhr1^+ Tg(MECP2)1Hzo/0	involves: 129S4/SvJae * 129S6/SvEv * C57BL/6 * FVB/N	MGI:5314415

Genotype
MGI:3037192

ht1

• Allelic Composition: Crhr1^tm1Wrst/Crhr1⁺
• Genetic Background: either: (involves: 129P2/OlaHsd * 129P/Ola) or (involves: 129P2/OlaHsd * CD-1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased behavioral withdrawal response ( J:76022 )

decreased anxiety-related response ( J:76022 )

• compared with homozygous mutant and wild-type mice, heterozygous mutant mice displayed an intermediate reduction in anxiety-related performance under ethanol-withdrawal conditions in the light-dark box, suggesting a gene-dosage effect

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:76022 )

N • heterozygous mutant males and females displayed normal basal levels of POMC1 (ACTH)

N • heterozygous mutant mice displayed a normal HPA axis response to forced-swim stress: similar to wild-type, heterozygous females and males responded by significantly increasing circulating levels of POMC1 (ACTH)

Genotype
MGI:5314415

cx2

• Allelic Composition: Crhr1^tm1Klee/Crhr1⁺; Tg(MECP2)1Hzo/0
• Genetic Background: involves: 129S4/SvJae * 129S6/SvEv * C57BL/6 * FVB/N

behavior/neurological

abnormal anxiety-related response ( J:181213 )

• anxiety-like behavior is reduced compared to single Tg(MECP2)1Hzo hemizygous mice, with double mutants being less anxious in the elevated plus maze and the light/dark box