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Crhr1tm1Wrst
Targeted Allele Detail
Summary
Symbol: Crhr1tm1Wrst
Name: corticotropin releasing hormone receptor 1; targeted mutation 1, Wolfgang Wurst
MGI ID: MGI:2178543
Synonyms: CRF1 KO, Crhr1 -
Gene: Crhr1  Location: Chr11:104023681-104066349 bp, + strand  Genetic Position: Chr11, 67.77 cM
Alliance: Crhr1tm1Wrst page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76022
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced a 3.1 kb genomic fragment containing sequences encoding transmembrane domains 4-7, including the G-coupling protein domain and the intracellular cytoplasmic tail. Extracellular field potential measurements in the CA1 region of the hippocampus confirmed disruption of CRH signal transduction: application of CRH increased the population spike amplitudes in CA1 slices of wild-type mice, but not in slices of homozygous mutant mice. (J:76022)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Crhr1 Mutation:  20 strains or lines available
References
Original:  J:76022 Timpl P, et al., Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1. Nat Genet. 1998 Jun;19(2):162-6
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory