Crhr1^tm1Klee
Targeted Allele Detail

Summary

• Symbol: Crhr1^tm1Klee
• Name: corticotropin releasing hormone receptor 1; targeted mutation 1, Kuo-Fen Lee
• MGI ID: MGI:2178544
• Synonyms: CRF1^-, CRF-R1-, CRFR1 -, CRH^tklee
• Gene: Crhr1 Location: Chr11:104023681-104066349 bp, + strand Genetic Position: Chr11, 67.77 cM
• Alliance: Crhr1^tm1Klee page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48280
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment containing exons 5-8, which encode part of the first transmembrane domain through the fourth transmembrane domain. (J:48280)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Crhr1 Mutation: 26 strains or lines available

References

• Original: J:48280 Smith GW, et al., Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development. Neuron. 1998 Jun;20(6):1093-102
• All: 38 reference(s)