About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cdk1+
wild type
MGI:2430278
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Cdk1tm1(Cdk2)Kald/Cdk1+ involves: 129 * C57BL/6 MGI:3818313
ht2
 		Cdk1tm3.1Kald/Cdk1+ involves: 129 * C57BL/6 MGI:6201525
cn3
 		Cdk1tm3Kald/Cdk1+
Tg(Stra8-icre)1Reb/0 		involves: 129 * C57BL/6 * FVB/NJ MGI:6201526
cn4
 		Cdk1tm3Kald/Cdk1+
Fbxo43tm1.2Kald/Fbxo43tm1.2Kald
Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+ 		involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL MGI:6201527
cx5
 		Cdk1tm1(Cdk2)Kald/Cdk1+
Cdk2tm1Kald/Cdk2tm1Kald 		involves: 129S1/Sv * C57BL/6 MGI:3818314


Genotype
MGI:3818313
ht1
Allelic
Composition		 Cdk1tm1(Cdk2)Kald/Cdk1+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk1tm1(Cdk2)Kald mutation (0 available); any Cdk1 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:141249 )
• mice are viable and fertile
• mice pass on the mutant allele to descendents




Genotype
MGI:6201525
ht2
Allelic
Composition		 Cdk1tm3.1Kald/Cdk1+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk1tm3.1Kald mutation (0 available); any Cdk1 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:251984 )
• early embryonic lethality




Genotype
MGI:6201526
cn3
Allelic
Composition		 Cdk1tm3Kald/Cdk1+
Tg(Stra8-icre)1Reb/0
Genetic
Background		 involves: 129 * C57BL/6 * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk1tm3Kald mutation (0 available); any Cdk1 mutation (21 available)
Tg(Stra8-icre)1Reb mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
azoospermia ( J:251984 )
• tubules contain only Sertoli cells with only rare spermatogonia

endocrine/exocrine glands

cellular
azoospermia ( J:251984 )
• tubules contain only Sertoli cells with only rare spermatogonia




Genotype
MGI:6201527
cn4
Allelic
Composition		 Cdk1tm3Kald/Cdk1+
Fbxo43tm1.2Kald/Fbxo43tm1.2Kald
Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk1tm3Kald mutation (0 available); any Cdk1 mutation (21 available)
Fbxo43tm1.2Kald mutation (0 available); any Fbxo43 mutation (29 available)
Gt(ROSA)26Sortm1(cre/ERT)Brn mutation (1 available); any Gt(ROSA)26Sor mutation (1098 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:251984 )
• within 4 to 5 days after treatment with tamoxifen at around age P21

reproductive system
azoospermia ( J:251984 )
• after treatment with tamoxifen at around age P21
arrest of male meiosis ( J:251984 )
• early in diplotene with some progression into metaphase
increased male germ cell apoptosis ( J:251984 )
• after treatment with tamoxifen at around age P21

cellular
azoospermia ( J:251984 )
• after treatment with tamoxifen at around age P21
arrest of male meiosis ( J:251984 )
• early in diplotene with some progression into metaphase
increased male germ cell apoptosis ( J:251984 )
• after treatment with tamoxifen at around age P21




Genotype
MGI:3818314
cx5
Allelic
Composition		 Cdk1tm1(Cdk2)Kald/Cdk1+
Cdk2tm1Kald/Cdk2tm1Kald
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk1tm1(Cdk2)Kald mutation (0 available); any Cdk1 mutation (21 available)
Cdk2tm1Kald mutation (0 available); any Cdk2 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
absent oocytes ( J:141249 )
• oocytes fail to develop in the atrophied ovaries of these mice
increased male germ cell apoptosis ( J:141249 )
• there is extensive apoptosis of male germ cells in 20-day old males
absent ovarian follicles ( J:141249 )
• no follicles are observed in the ovaries of 90-day old mice
small ovary ( J:141249 )
• ovaries of adult female mice are only half the size of controls
decreased round spermatid number ( J:141249 )
• round spermatids are absent in the testis of 20-day old males
abnormal spermatocyte morphology ( J:141249 )
• spermatocyte numbers are depleted in the testes of 3-month old mice
• there is an increase in the number of apoptotic spermatocytes in the testes of 10-day old mice
abnormal male meiosis ( J:141249 )
• a greater number of spermatocytes reach the pachytene stage of meiosis than controls
small seminiferous tubules ( J:141249 )
• the seminiferous tubules are much smaller in 3-month old males
small testis ( J:141249 )
• testis are 20-30% smaller than controls at twenty days of age
• testis of adult males are only half the size of controls
infertility ( J:141249 )
• both male and female mice are sterile

endocrine/exocrine glands
absent ovarian follicles ( J:141249 )
• no follicles are observed in the ovaries of 90-day old mice
small ovary ( J:141249 )
• ovaries of adult female mice are only half the size of controls
small seminiferous tubules ( J:141249 )
• the seminiferous tubules are much smaller in 3-month old males
small testis ( J:141249 )
• testis are 20-30% smaller than controls at twenty days of age
• testis of adult males are only half the size of controls

cellular
absent oocytes ( J:141249 )
• oocytes fail to develop in the atrophied ovaries of these mice
decreased round spermatid number ( J:141249 )
• round spermatids are absent in the testis of 20-day old males
abnormal spermatocyte morphology ( J:141249 )
• spermatocyte numbers are depleted in the testes of 3-month old mice
• there is an increase in the number of apoptotic spermatocytes in the testes of 10-day old mice
abnormal male meiosis ( J:141249 )
• a greater number of spermatocytes reach the pachytene stage of meiosis than controls
increased male germ cell apoptosis ( J:141249 )
• there is extensive apoptosis of male germ cells in 20-day old males




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory