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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd22+
wild type
MGI:2430254
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Cd22tm1Eac/Cd22+
Tg(IghelMD4)4Ccg/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:3852088
cx2
 		Cd22tm1Eac/Cd22+
Lyntm1Ard/Lyn+
Ptpn6me-v/Ptpn6+
Tg(IghelMD4)4Ccg/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:3852089
cx3
 		Cd22tm1Eac/Cd22+
Ptpn6me-v/Ptpn6+
Tg(IghelMD4)4Ccg/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:3852090
cx4
 		Cd22tm1Eac/Cd22+
Lyntm1Ard/Lyn+
Tg(IghelMD4)4Ccg/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:3852091


Genotype
MGI:3852088
cx1
Allelic
Composition		 Cd22tm1Eac/Cd22+
Tg(IghelMD4)4Ccg/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd22tm1Eac mutation (1 available); any Cd22 mutation (62 available)
Tg(IghelMD4)4Ccg mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mature B cell morphology ( J:110531 )
• expression of CD22 on the surface of cells is half that of controls
• surface expression of IgM is about 70-80% of controls

hematopoietic system
abnormal mature B cell morphology ( J:110531 )
• expression of CD22 on the surface of cells is half that of controls
• surface expression of IgM is about 70-80% of controls




Genotype
MGI:3852089
cx2
Allelic
Composition		 Cd22tm1Eac/Cd22+
Lyntm1Ard/Lyn+
Ptpn6me-v/Ptpn6+
Tg(IghelMD4)4Ccg/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd22tm1Eac mutation (1 available); any Cd22 mutation (62 available)
Lyntm1Ard mutation (7 available); any Lyn mutation (66 available)
Ptpn6me-v mutation (4 available); any Ptpn6 mutation (47 available)
Tg(IghelMD4)4Ccg mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell negative selection ( J:110531 )
• when mutant bone marrow is transferred to mice expressing hen egg lysozyme, B cell maturation is almost completely blocked at the immature B cell stage
abnormal mature B cell morphology ( J:110531 )
• surface expression of IgM is only 15% of controls
increased IgM level ( J:110531 )
• half the mice have a 15-fold increase in Hel-specific serum IgM

hematopoietic system
abnormal B cell negative selection ( J:110531 )
• when mutant bone marrow is transferred to mice expressing hen egg lysozyme, B cell maturation is almost completely blocked at the immature B cell stage
abnormal mature B cell morphology ( J:110531 )
• surface expression of IgM is only 15% of controls
increased IgM level ( J:110531 )
• half the mice have a 15-fold increase in Hel-specific serum IgM




Genotype
MGI:3852090
cx3
Allelic
Composition		 Cd22tm1Eac/Cd22+
Ptpn6me-v/Ptpn6+
Tg(IghelMD4)4Ccg/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd22tm1Eac mutation (1 available); any Cd22 mutation (62 available)
Ptpn6me-v mutation (4 available); any Ptpn6 mutation (47 available)
Tg(IghelMD4)4Ccg mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell negative selection ( J:110531 )
• when mutant bone marrow is transferred to mice expressing hen egg lysozyme, B cell maturation is partially blocked at the immature B cell stage
abnormal mature B cell morphology ( J:110531 )
• surface expression of IgM is less than half of controls

hematopoietic system
abnormal B cell negative selection ( J:110531 )
• when mutant bone marrow is transferred to mice expressing hen egg lysozyme, B cell maturation is partially blocked at the immature B cell stage
abnormal mature B cell morphology ( J:110531 )
• surface expression of IgM is less than half of controls




Genotype
MGI:3852091
cx4
Allelic
Composition		 Cd22tm1Eac/Cd22+
Lyntm1Ard/Lyn+
Tg(IghelMD4)4Ccg/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd22tm1Eac mutation (1 available); any Cd22 mutation (62 available)
Lyntm1Ard mutation (7 available); any Lyn mutation (66 available)
Tg(IghelMD4)4Ccg mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell negative selection ( J:110531 )
• when mutant bone marrow is transferred to mice expressing hen egg lysozyme, B cell maturation is patially blocked at the immature B cell stage
abnormal mature B cell morphology ( J:110531 )
• surface expression of IgM is less than half of controls

hematopoietic system
abnormal B cell negative selection ( J:110531 )
• when mutant bone marrow is transferred to mice expressing hen egg lysozyme, B cell maturation is patially blocked at the immature B cell stage
abnormal mature B cell morphology ( J:110531 )
• surface expression of IgM is less than half of controls




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory