Phenotypes associated with this allele

• Allele Symbol: Nr3c1⁺
• Allele Name: wild type
• Allele ID: MGI:2430017
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Nr3c1^tm2.1Gsc/Nr3c1^+	B6.129P2-Nr3c1^tm2.1Gsc	MGI:3817865
ht2	Nr3c1^Gt(ESKN92)Hgs/Nr3c1^+	B6.Cg-Nr3c1^Gt(ESKN92)Hgs	MGI:3817770
ht3	Nr3c1^tm1Dage/Nr3c1^+	involves: 129P1/ReJ * C57BL/6 * C57BL/6J * SJL	MGI:3843006
cn4	Nr3c1^tm1.1Jda/Nr3c1^+ Tg(Lck-cre)548Jxm/0	B6.Cg-Nr3c1^tm1.1Jda Tg(Lck-cre)548Jxm	MGI:5447540
cn5	Nr3c1^tm1.1Mvc/Nr3c1^+ Tg(Sim1-cre)1Lowl/0	involves: 129 * C57BL/6 * FVB	MGI:5306344

Genotype
MGI:3817865

ht1

• Allelic Composition: Nr3c1^tm2.1Gsc/Nr3c1⁺
• Genetic Background: B6.129P2-Nr3c1^tm2.1Gsc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell apoptosis ( J:126427 )

• the dose-response curve of glucocorticoid induced T lymphocyte apoptosis is shifted to higher concentrations compared to in wild-type mice

increased susceptibility to experimental autoimmune encephalomyelitis ( J:137157 )

• when subjected to a MOG induced model of experimental autoimmune encephalitis, mice exhibit increased clinical score, resistance to the beneficial effects of dexamethasone treatment and increased T cell and macrophage infiltration compared to in similarly treated wild-type mice

• mice subjected to MOG induced model of experimental autoimmune encephalitis exhibit decreased blood brain barrier integrity

nervous system

abnormal blood-brain barrier function ( J:137157 )

• mice subjected to MOG induced model of experimental autoimmune encephalitis exhibit decreased blood brain barrier integrity

cardiovascular system

abnormal blood-brain barrier function ( J:137157 )

• mice subjected to MOG induced model of experimental autoimmune encephalitis exhibit decreased blood brain barrier integrity

cellular

decreased T cell apoptosis ( J:126427 )

• the dose-response curve of glucocorticoid induced T lymphocyte apoptosis is shifted to higher concentrations compared to in wild-type mice

hematopoietic system

decreased T cell apoptosis ( J:126427 )

• the dose-response curve of glucocorticoid induced T lymphocyte apoptosis is shifted to higher concentrations compared to in wild-type mice

Genotype
MGI:3817770

ht2

• Allelic Composition: Nr3c1^{Gt(ESKN92)Hgs}/Nr3c1⁺
• Genetic Background: B6.Cg-Nr3c1^{Gt(ESKN92)Hgs}

endocrine/exocrine glands

abnormal adrenal gland morphology ( J:141205 )

• especially when fed a low fat diet, mice exhibit signs of stimulation of corticosterone and aldosterone producing cells in the zona fasciculate and glomerulosa, respectively, unlike in wild-type mice

• alterations in adrenal gland morphology between mice fed a low fat diet and mice fed a high fat diet are less pronounced than in wild-type mice

abnormal adrenal gland zona fasciculata morphology ( J:141205 )

• column of endocrine cells in the zona fasciculate are longer than in wild-type cells and individual cells have homogeneous eosinophilic cytoplasm

abnormal adrenal gland zona glomerulosa morphology ( J:141205 )

• the zona glomerulosa appears thicker with more glomeruli and hypertrophied epithelium than in wild-type mice

enlarged adrenal glands ( J:141205 )

• adrenal gland weight is higher than in wild-type mice

• unlike in wild-type mice, no additional increase in adrenal gland weight is observed when mice are fed a high fat diet

• enlarged adrenal glands exhibit hyperplasia rather than cellular hypertrophy

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:141205 )

N • mice exhibit normal glucose metabolism when fed a low fat or high fat diet

abnormal circulating corticosterone level ( J:141205 )

• when fed a high fat diet, mice fail to exhibit an increase in corticosterone levels as do wild-type mice

increased circulating corticosterone level ( J:141205 )

• when fed a low fat diet, plasma corticosterone levels are 2-fold higher than in wild-type mice

increased circulating aldosterone level ( J:141205 )

increased circulating angiotensinogen level ( J:141205 )

• when fed a high fat diet, angiotensin levels are increased 3-fold compared to in wild-type mice

increased liver triglyceride level ( J:141205 )

• in the liver when mice are fed a high fat diet

increased renin activity ( J:141205 )

• mice exhibit a 2-fold increase in renin activity compared to in wild-type mice

adipose tissue

adipose tissue phenotype ( J:141205 )

N • mice exhibit normal adipose distribution when fed a low fat or high fat diet

cardiovascular system

increased systemic arterial systolic blood pressure ( J:141205 )

• when fed a low fat diet, mice exhibit hypertension but fail to exhibit further increases in systolic blood pressure when fed a high fat diet

growth/size/body

growth/size/body region phenotype ( J:141205 )

N • mice exhibit normal weight when fed a low fat or high fat diet

renal/urinary system

renal/urinary system phenotype ( J:141205 )

N • despite activation of the renin-angiotension-aldosterone system, mice exhibit normal kidney morphology and function

liver/biliary system

increased liver triglyceride level ( J:141205 )

• in the liver when mice are fed a high fat diet

Genotype
MGI:3843006

ht3

• Allelic Composition: Nr3c1^tm1Dage/Nr3c1⁺
• Genetic Background: involves: 129P1/ReJ * C57BL/6 * C57BL/6J * SJL

Reduced adrenal weight in Nr3c1^tm1Dage/Nr3c1^tm1Dage and Nr3c1^tm1Dage/Nr3c1⁺ mice

homeostasis/metabolism

decreased circulating testosterone level ( J:147914 )

• mice treated with dexamethasone exhibit reduced testosterone levels compared to in similarly treated wild-type mice

decreased circulating corticosterone level ( J:147914 )

• at morning nadir, evening diurnal peak, during food deprivation, and following injection with ACTH compared to in wild-type mice

decreased circulating adrenocorticotropin level ( J:147914 )

• at morning nadir, evening diurnal peak, and during stress compared to in wild-type mice

abnormal physiological response to xenobiotic ( J:147914 )

• low dose dexamethasone results in increased mean arterial blood pressure unlike in wild-type mice that is more pronounced during the daytime phase

• mice treated with dexamethasone exhibit reduced testosterone levels compared to in similarly treated wild-type mice

endocrine/exocrine glands

decreased adrenal gland zona fasciculata size ( J:147914 )

• reduced in size

thin adrenal cortex ( J:147914 )

small adrenal glands ( J:147914 )

• 55% of wild-type

immune system

decreased B cell number ( J:147914 )

• when bone marrow cells are transplanted into wild-type mice

cardiovascular system

increased mean systemic arterial blood pressure ( J:147914 )

• low dose dexamethasone results in increased mean arterial blood pressure unlike in wild-type mice that is more pronounced during the daytime phase

hematopoietic system

decreased B cell number ( J:147914 )

• when bone marrow cells are transplanted into wild-type mice

Genotype
MGI:5447540

cn4

• Allelic Composition: Nr3c1^tm1.1Jda/Nr3c1⁺; Tg(Lck-cre)548Jxm/0
• Genetic Background: B6.Cg-Nr3c1^tm1.1Jda Tg(Lck-cre)548Jxm

immune system

decreased thymocyte apoptosis ( J:189951 )

• thymocytes are less sensitive to dexamethasone-induced apoptosis compared with wild-type cells

cellular

decreased thymocyte apoptosis ( J:189951 )

• thymocytes are less sensitive to dexamethasone-induced apoptosis compared with wild-type cells

hematopoietic system

decreased thymocyte apoptosis ( J:189951 )

• thymocytes are less sensitive to dexamethasone-induced apoptosis compared with wild-type cells

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:189951 )

• thymocytes are less sensitive to dexamethasone-induced apoptosis compared with wild-type cells

Genotype
MGI:5306344

cn5

• Allelic Composition: Nr3c1^tm1.1Mvc/Nr3c1⁺; Tg(Sim1-cre)1Lowl/0
• Genetic Background: involves: 129 * C57BL/6 * FVB

growth/size/body

decreased body weight ( J:179918 )

• during adulthood

homeostasis/metabolism

increased circulating corticosterone level ( J:179918 )

increased circulating adrenocorticotropin level ( J:179918 )

nervous system

abnormal hypothalamus physiology ( J:179918 )

• elevated immunoreactivity for corticotropin-releasing hormone in the paraventricular nucleus