Nr3c1^tm1Dage
Targeted Allele Detail

Summary

• Symbol: Nr3c1^tm1Dage
• Name: nuclear receptor subfamily 3, group C, member 1; targeted mutation 1, David Geller
• MGI ID: MGI:3842978
• Synonyms: GR^M610L
• Gene: Nr3c1 Location: Chr18:39543598-39652474 bp, - strand Genetic Position: Chr18, 21.09 cM
• Alliance: Nr3c1^tm1Dage page

Reduced adrenal weight in Nr3c1^tm1Dage/Nr3c1^tm1Dage and Nr3c1^tm1Dage/Nr3c1⁺ mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147914
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P1/ReJ

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: An A to C nucleotide substitution at position 1828 results in the amino acid substitution of leucine for methionine at position 610 (M610L). An frt flanked neo cassette inserted downstream of exon 6 that was removed by subsequent germ line flp mediated recombination. (J:147914)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr3c1 Mutation: 34 strains or lines available

References

• Original: J:147914 Zhang J, et al., Characterization of a novel gain of function glucocorticoid receptor knock-in mouse. J Biol Chem. 2009 Mar 6;284(10):6249-59
• All: 1 reference(s)