Nr3c1^{Gt(ESKN92)Hgs}
Gene trapped Allele Detail

Summary

• Symbol: Nr3c1^{Gt(ESKN92)Hgs}
• Name: nuclear receptor subfamily 3, group C, member 1; gene trap ESKN92, Heidi Sutherland
• MGI ID: MGI:3817754
• Synonyms: GR^betageo, Nr3c1^{gtESK92MRCHGU}
• Gene: Nr3c1 Location: Chr18:39543598-39652474 bp, - strand Genetic Position: Chr18, 21.09 cM
• Alliance: Nr3c1^{Gt(ESKN92)Hgs} page

Mutation origin

• Mutant Cell Line: ESKN92
• Germline Transmission: Earliest citation of germline transmission: J:141205
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Hypomorph)
• Mutation: Insertion of gene trap vector Vector Type: gene trap
• Mutation details: A beta-geo cassette was inserted between exon 3 and exon 4. A 50% decrease in transcript expression was confirmed by quantitative PCR on adipose tissue, muscle, liver, and adrenal gland from heterozygous mice. (J:141205)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr3c1 Mutation: 34 strains or lines available

References

• Original: J:141205 Michailidou Z, et al., Glucocorticoid receptor haploinsufficiency causes hypertension and attenuates hypothalamic-pituitary-adrenal axis and blood pressure adaptions to high-fat diet. FASEB J. 2008 Nov;22(11):3896-907
• All: 5 reference(s)