Analysis Tools
mortality/aging
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• despite Mendelian ratios of embryos, no mice survive to adulthood
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Allele Symbol Allele Name Allele ID |
Nr3c1Gt(ESKN92)Hgs gene trap ESKN92, Heidi Sutherland MGI:3817754 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• despite Mendelian ratios of embryos, no mice survive to adulthood
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• especially when fed a low fat diet, mice exhibit signs of stimulation of corticosterone and aldosterone producing cells in the zona fasciculate and glomerulosa, respectively, unlike in wild-type mice
• alterations in adrenal gland morphology between mice fed a low fat diet and mice fed a high fat diet are less pronounced than in wild-type mice
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• column of endocrine cells in the zona fasciculate are longer than in wild-type cells and individual cells have homogeneous eosinophilic cytoplasm
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• the zona glomerulosa appears thicker with more glomeruli and hypertrophied epithelium than in wild-type mice
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• adrenal gland weight is higher than in wild-type mice
• unlike in wild-type mice, no additional increase in adrenal gland weight is observed when mice are fed a high fat diet
• enlarged adrenal glands exhibit hyperplasia rather than cellular hypertrophy
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| N |
• mice exhibit normal glucose metabolism when fed a low fat or high fat diet
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• when fed a high fat diet, mice fail to exhibit an increase in corticosterone levels as do wild-type mice
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• when fed a low fat diet, plasma corticosterone levels are 2-fold higher than in wild-type mice
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• when fed a high fat diet, angiotensin levels are increased 3-fold compared to in wild-type mice
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• in the liver when mice are fed a high fat diet
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• mice exhibit a 2-fold increase in renin activity compared to in wild-type mice
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| N |
• mice exhibit normal adipose distribution when fed a low fat or high fat diet
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• when fed a low fat diet, mice exhibit hypertension but fail to exhibit further increases in systolic blood pressure when fed a high fat diet
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| N |
• mice exhibit normal weight when fed a low fat or high fat diet
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| N |
• despite activation of the renin-angiotension-aldosterone system, mice exhibit normal kidney morphology and function
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• in the liver when mice are fed a high fat diet
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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