Phenotypes associated with this allele
Allelic
Composition |
Acrtm1Wen/Acrtm1Wen
|
|
Genetic
Background |
involves: 129S1/Sv * 129X1/SvJ * CD-1 |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acrtm1Wen mutation
(0 available);
any
Acr mutation
(48 available)
|
|
|
reproductive system
|
|
• although sperm from homozygous mutants were able to penetrate oocytes, they exhibited delayed fertilization
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acrtm1Wen mutation
(0 available);
any
Acr mutation
(48 available)
H1f1tm1Drab mutation
(0 available);
any
H1f1 mutation
(6 available)
Tnp2tm1Wen mutation
(0 available);
any
Tnp2 mutation
(5 available)
|
|
|
normal phenotype
|
|
• viable and fertile with normal litter sizes and normal sperm numbers, morphology and physiology
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acrtm1Wen mutation
(0 available);
any
Acr mutation
(48 available)
H1f1tm1Drab mutation
(0 available);
any
H1f1 mutation
(6 available)
Smcptm1Wen mutation
(0 available);
any
Smcp mutation
(15 available)
|
|
|
reproductive system
 |
• significant alterations in sperm velocities, amplitude, and forward movement indicating decreased sperm motility compared to wild-type, however did not observe reduced migration of sperm in the female genital tract
• greater decrease in sperm motility than in triple homozygous Tnp2/Hist1h1t/Mcsp mice
|
|
|
• litter size was sharply reduced when mutant males were mated to wild-type females
|
|
|
• only 8%-15% of wild-type oocytes were fertilized by mutant sperm (compared to 84.8% by wild-type sperm), but 71-75% of the fertilized oocytes developed into normal blastocysts (compared to 61.5% of the controls)
|
|
|
• reduced binding of sperm to zona pellucida from wild-type females
|
cellular
|
|
• significant alterations in sperm velocities, amplitude, and forward movement indicating decreased sperm motility compared to wild-type, however did not observe reduced migration of sperm in the female genital tract
• greater decrease in sperm motility than in triple homozygous Tnp2/Hist1h1t/Mcsp mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acrtm1Wen mutation
(0 available);
any
Acr mutation
(48 available)
Smcptm1Wen mutation
(0 available);
any
Smcp mutation
(15 available)
Tnp2tm1Wen mutation
(0 available);
any
Tnp2 mutation
(5 available)
|
|
|
reproductive system
|
|
• reduced number of sperm in oviducts of wild-type females, indicating that migration of sperm through the female genital tract is impaired
|
|
|
• significant alterations in sperm velocities, amplitude, and forward movement, indicating decreased sperm motility compared to wild-type
|
|
|
• produced no offspring when mated to wild-type females
|
|
|
• reduced binding of sperm to zona pellucida from wild-type females
|
cellular
|
|
• reduced number of sperm in oviducts of wild-type females, indicating that migration of sperm through the female genital tract is impaired
|
|
|
• significant alterations in sperm velocities, amplitude, and forward movement, indicating decreased sperm motility compared to wild-type
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acrtm1Wen mutation
(0 available);
any
Acr mutation
(48 available)
H1f6tm1Drab mutation
(0 available);
any
H1f6 mutation
(17 available)
Smcptm1Wen mutation
(0 available);
any
Smcp mutation
(15 available)
|
|
|
reproductive system
|
|
• 18% of sperm (compared to 7.7% of wild-type) had abnormal sperm head shapes that were broader and less pointed than wild-type
|
|
|
• reduced number of sperm in oviducts of wild-type females, indicating that migration of sperm through the female genital tract is impaired
|
|
|
• significant alterations in sperm velocities, beat frequency, amplitude, straightness threshold and forward movement, indicating decreased sperm motility compared to wild-type
• greater decrease in sperm motility than in triple homozygous Tnp2/Hist1h1t/Mcsp mice
|
|
|
• litter size was sharply reduced when mutant males were mated to wild-type females
|
|
|
• only 8%-15% of wild-type oocytes were fertilized by mutant sperm (compared to 84.8% by wild-type sperm), but 71-75% of the fertilized oocytes developed into normal blastocysts (compared to 61.5% of the controls)
|
|
|
• reduced binding of sperm to zona pellucida from wild-type females
|
cellular
|
|
• 18% of sperm (compared to 7.7% of wild-type) had abnormal sperm head shapes that were broader and less pointed than wild-type
|
|
|
• reduced number of sperm in oviducts of wild-type females, indicating that migration of sperm through the female genital tract is impaired
|
|
|
• significant alterations in sperm velocities, beat frequency, amplitude, straightness threshold and forward movement, indicating decreased sperm motility compared to wild-type
• greater decrease in sperm motility than in triple homozygous Tnp2/Hist1h1t/Mcsp mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acrtm1Wen mutation
(0 available);
any
Acr mutation
(48 available)
H1f6tm1Ais mutation
(0 available);
any
H1f6 mutation
(17 available)
Tnp2tm1Wen mutation
(0 available);
any
Tnp2 mutation
(5 available)
|
|
|
normal phenotype
|
|
• viable and fertile with normal litter sizes and normal sperm numbers, morphology and physiology
|
Analysis Tools
