Analysis Tools
vision/eye
| N |
• normal numbers of retinal ganglion cells and normal optic nerve morphology are seen
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Allele Symbol Allele Name Allele ID |
Pou4f2tm2Whk targeted mutation 2, William H Klein MGI:2429634 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• normal numbers of retinal ganglion cells and normal optic nerve morphology are seen
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E15.5 retinal ganglion cell apoptosis is seen and at E17.5 loss of these cells is accelerated and propagated from the central to the peripheral retina
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• a loss of 70% of the retinal ganglion cells in the retinal ganglion cell layer is seen at 6 weeks of age
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• fewer and less fasciculated axon bundles projecting into the optic disc
• the cross-sectional area of the optic nerve is reduced
• an increased proportion of the axons project into the ipsilateral optic track or into the optic nerve of the opposite eye
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• retinal ganglion axons fail to reach the midline at E13.5
• At E15.5, the axons in the optic nerve are less fasciculated and appear to be grouped into two bundles
• in addition, a substantial portion of retinal ganglion cells fail to send out axons or their axons do not exit the optic cup
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• a loss of 70% of the retinal ganglion cells in the retinal ganglion cell layer is seen at 6 weeks of age
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• fewer and less fasciculated axon bundles projecting into the optic disc
• the cross-sectional area of the optic nerve is reduced
• an increased proportion of the axons project into the ipsilateral optic track or into the optic nerve of the opposite eye
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• retinal ganglion axons fail to reach the midline at E13.5
• At E15.5, the axons in the optic nerve are less fasciculated and appear to be grouped into two bundles
• in addition, a substantial portion of retinal ganglion cells fail to send out axons or their axons do not exit the optic cup
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• at E15.5 retinal ganglion cell apoptosis is seen and at E17.5 loss of these cells is accelerated and propagated from the central to the peripheral retina
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• retinal ganglion cells expressing Pou4f1 are severely reduced in adult retina
• adult mice only have about 5% the number of retinal ganglion cells as do the controls
• genesis of RGCs are not affected as they are present in E13.5 embryos
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• the optic nerve is barely detectable in adults with only a very limited number of axon bundles present
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• retinal ganglion cells expressing Pou4f1 are severely reduced in adult retina
• adult mice only have about 5% the number of retinal ganglion cells as do the controls
• genesis of RGCs are not affected as they are present in E13.5 embryos
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• the optic nerve is barely detectable in adults with only a very limited number of axon bundles present
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• retinal ganglion cells expressing Pou4f1 are severely reduced in adult retina
• adult mice only have about 5% the number of retinal ganglion cells as do the controls
• genesis of RGCs are not affected as they are present in E13.5 embryos
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• the optic nerve is barely detectable in adults with only a very limited number of axon bundles present
|
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• retinal ganglion cells expressing Pou4f1 are severely reduced in adult retina
• adult mice only have about 5% the number of retinal ganglion cells as do the controls
• genesis of RGCs are not affected as they are present in E13.5 embryos
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• the optic nerve is barely detectable in adults with only a very limited number of axon bundles present
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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