All Phenotypes Rag1<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rag1⁺
wild type
MGI:2429493

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Rag1^tm1Jsek/Rag1⁺	involves: 129S6/SvEvTac	MGI:3840833
cn2	Ewsr1^tm1(ERG)Thr/Ewsr1⁺ Rag1^tm1(cre)Thr/Rag1⁺	involves: 129S/SvEv	MGI:3603039
cn3	Lmo2^tm3Thr/Lmo2^tm4Thr Rag1^tm1(cre)Thr/Rag1⁺	involves: 129S/SvEv	MGI:3584438
cn4	Ctps1^{tm1c(KOMP)Wtsi}/Ctps1^{tm1c(KOMP)Wtsi} Tg(Cd4-cre)1Cwi/0 Foxp3^sf/Y Rag1^tm1Mom/Rag1⁺	mixed	MGI:7659107
cx5	Inpp5d^tm1Rkh/Inpp5d^tm1Rkh Rag1^tm1(GFP)Imku/Rag1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:3838991
cx6	Lck^tm1Mak/Lck^tm1Mak Rag1^tm1Mom/Rag1⁺ Tg(Lck-Fyn*Y528F)5525Cjg/0	involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6	MGI:4360345
cx7	Rag1^tm1Mom/Rag1⁺ Tg(LPV-TAg1135)11Tvd/0 Tg(TcrLCMV)327Sdz/0	involves: 129S7/SvEvBrd * C57BL/6 * DBA/2	MGI:2665135
cx8	Rag1^tm1Mom/Rag1⁺ Tg(LPV-TAg1135)11Tvd/0	involves: 129/Sv * C57BL/6 * DBA/2	MGI:2665123

Allelic Composition	Rag1^tm1Jsek/Rag1⁺
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1^tm1Jsek mutation (0 available); any Rag1 mutation (133 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:146912 )

• B cell development becomes impaired in mice over 1 year of age

• in the bone marrow of year old mice, significantly fewer B220⁺CD43⁺ pro-B cells progress to the B220⁺CD43^- pre-B and B220⁺IgM⁺ stages of development

abnormal immunoglobulin heavy chain V(D)J recombination ( J:146912 )

• IgH-D to IgH-J rearrangements are impaired in sorted pro-B- and pre-B-cell populations of mice one year of age compared to controls

abnormal T cell differentiation ( J:146912 )

• T cell development becomes impaired in mice over 1 year of age

• there is a significant decrease in the percentage and number of double-positive thymocytes of year old mice compared to age-matched wild-type controls

abnormal T cell receptor beta chain V(D)J recombination ( J:146912 )

• Dbeta to Jbeta rearrangements are impaired in thymocytes of mice over 1 year of age compared to controls

decreased double-positive T cell number ( J:146912 )

• there is a significant decrease in the percentage and number of double-positive thymocytes of year old mice compared to age-matched wild-type controls

hematopoietic system

abnormal B cell differentiation ( J:146912 )

• B cell development becomes impaired in mice over 1 year of age

• in the bone marrow of year old mice, significantly fewer B220⁺CD43⁺ pro-B cells progress to the B220⁺CD43^- pre-B and B220⁺IgM⁺ stages of development

abnormal immunoglobulin heavy chain V(D)J recombination ( J:146912 )

• IgH-D to IgH-J rearrangements are impaired in sorted pro-B- and pre-B-cell populations of mice one year of age compared to controls

abnormal T cell differentiation ( J:146912 )

• T cell development becomes impaired in mice over 1 year of age

• there is a significant decrease in the percentage and number of double-positive thymocytes of year old mice compared to age-matched wild-type controls

abnormal T cell receptor beta chain V(D)J recombination ( J:146912 )

• Dbeta to Jbeta rearrangements are impaired in thymocytes of mice over 1 year of age compared to controls

decreased double-positive T cell number ( J:146912 )

• there is a significant decrease in the percentage and number of double-positive thymocytes of year old mice compared to age-matched wild-type controls

Allelic Composition	Ewsr1^tm1(ERG)Thr/Ewsr1⁺ Rag1^tm1(cre)Thr/Rag1⁺
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ewsr1^tm1(ERG)Thr mutation (0 available); any Ewsr1 mutation (93 available)
Rag1^tm1(cre)Thr mutation (0 available); any Rag1 mutation (133 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased T cell derived lymphoma incidence ( J:98679 )

• associated with leukemia

increased leukemia incidence ( J:98679 )

• mutant mice develop leukemia involving T cells with infiltrating lymphoblasts in the bone marrow, liver, and kidney

immune system

increased T cell derived lymphoma incidence ( J:98679 )

• associated with leukemia

increased lymphocyte cell number ( J:98679 )

• associated with leukemia

hematopoietic system

increased T cell derived lymphoma incidence ( J:98679 )

• associated with leukemia

increased lymphocyte cell number ( J:98679 )

• associated with leukemia

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:98679 )

• associated with leukemia

Allelic Composition	Lmo2^tm3Thr/Lmo2^tm4Thr Rag1^tm1(cre)Thr/Rag1⁺
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmo2^tm3Thr mutation (0 available); any Lmo2 mutation (30 available)
Lmo2^tm4Thr mutation (0 available); any Lmo2 mutation (30 available)
Rag1^tm1(cre)Thr mutation (0 available); any Rag1 mutation (133 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:86869 )

N	• mutant mice are viable and exhibit no hematopoietic defects, with normal bone marrow, spleen and thymus cell counts

immune system

immune system phenotype ( J:86869 )

N	• normal T and B lymphoid development

Allelic Composition	Ctps1^{tm1c(KOMP)Wtsi}/Ctps1^{tm1c(KOMP)Wtsi} Tg(Cd4-cre)1Cwi/0 Foxp3^sf/Y Rag1^tm1Mom/Rag1⁺
Genetic Background	mixed

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctps1^{tm1c(KOMP)Wtsi} mutation (0 available); any Ctps1 mutation (46 available)
Foxp3^sf mutation (5 available); any Foxp3 mutation (57 available)
Rag1^tm1Mom mutation (56 available); any Rag1 mutation (133 available)
Tg(Cd4-cre)1Cwi mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:348981 )

• weight does not reach control levels at 40-50 days and 60-75 days

enlarged spleen ( J:348981 )

• by day 44, mice develop enlarged spleen

endocrine/exocrine glands

thymus hypoplasia ( J:348981 )

• by day 44, thymus has reduced cellularity

immune system

decreased T cell proliferation ( J:348981 )

• both CD8+ and CD4+ T cells show a reduced capacity to expand in response to CD3/CD28 stimulation

thymus hypoplasia ( J:348981 )

• by day 44, thymus has reduced cellularity

enlarged spleen ( J:348981 )

• by day 44, mice develop enlarged spleen

decreased regulatory T cell number ( J:348981 )

• mice exhibit a deficiency in T regulatory cells (CD4+, CD25+, FoxP3+)

decreased inflammatory response ( J:348981 )

• mice show prevention of the fatal systemic autoimmune and inflammatory disease that is seen in Foxp3^sf/Y mice, with mice surviving at least up to 80 days and no presentation of scaly tails and ears, and no inflammation and tissue disruption at day 44

• values of total T cells return to normal and the accumulation of effector memory CD4+ and CD8+ T cells in the spleen that is seen in single Foxp3/Y mice is reduced

hematopoietic system

decreased T cell proliferation ( J:348981 )

• both CD8+ and CD4+ T cells show a reduced capacity to expand in response to CD3/CD28 stimulation

thymus hypoplasia ( J:348981 )

• by day 44, thymus has reduced cellularity

enlarged spleen ( J:348981 )

• by day 44, mice develop enlarged spleen

decreased regulatory T cell number ( J:348981 )

• mice exhibit a deficiency in T regulatory cells (CD4+, CD25+, FoxP3+)

cellular

decreased T cell proliferation ( J:348981 )

• both CD8+ and CD4+ T cells show a reduced capacity to expand in response to CD3/CD28 stimulation

Allelic Composition	Inpp5d^tm1Rkh/Inpp5d^tm1Rkh Rag1^tm1(GFP)Imku/Rag1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Inpp5d^tm1Rkh mutation (0 available); any Inpp5d mutation (95 available)
Rag1^tm1(GFP)Imku mutation (0 available); any Rag1 mutation (133 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal lymphopoiesis ( J:117320 )

• there is a defect in development of early-lymphoid progenitors

• no GFP-positive cells are observed in the Lin^-c-Kit^hiSca-1⁺ cell population in the bone marrow compared 9% of the population being GFP-positive in Rag1^tm1(GFP)Imku heterozygotes

• there is a 10-fold decrease in Lin^-c-Kit^loSca-1^loGFP⁺ population in the bone marrow, corresponding to the prolymphocyte fraction

immune system

abnormal lymphopoiesis ( J:117320 )

• there is a defect in development of early-lymphoid progenitors

• no GFP-positive cells are observed in the Lin^-c-Kit^hiSca-1⁺ cell population in the bone marrow compared 9% of the population being GFP-positive in Rag1^tm1(GFP)Imku heterozygotes

• there is a 10-fold decrease in Lin^-c-Kit^loSca-1^loGFP⁺ population in the bone marrow, corresponding to the prolymphocyte fraction

Allelic Composition	Lck^tm1Mak/Lck^tm1Mak Rag1^tm1Mom/Rag1⁺ Tg(Lck-Fyn*Y528F)5525Cjg/0
Genetic Background	involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lck^tm1Mak mutation (1 available); any Lck mutation (96 available)
Rag1^tm1Mom mutation (56 available); any Rag1 mutation (133 available)
Tg(Lck-Fyn*Y528F)5525Cjg mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal T cell differentiation ( J:37062 )

• the transgene partially rescues arrest of T cell development associated with Lck deficiency

• thymocyte numbers are normal

• splenic gamma-delta T cell numbers are normal

• expression of TCR and CD5 on transitional single-positive thymocytes is slightly lower than controls

decreased T cell number ( J:37062 )

• alpha beta T cell numbers are less than half of wild-type controls

immune system

abnormal T cell differentiation ( J:37062 )

• the transgene partially rescues arrest of T cell development associated with Lck deficiency

• thymocyte numbers are normal

• splenic gamma-delta T cell numbers are normal

• expression of TCR and CD5 on transitional single-positive thymocytes is slightly lower than controls

decreased T cell number ( J:37062 )

• alpha beta T cell numbers are less than half of wild-type controls

Allelic Composition	Rag1^tm1Mom/Rag1⁺ Tg(LPV-TAg1135)11Tvd/0 Tg(TcrLCMV)327Sdz/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1^tm1Mom mutation (56 available); any Rag1 mutation (133 available)
Tg(LPV-TAg1135)11Tvd mutation (0 available)
Tg(TcrLCMV)327Sdz mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:47667 )

• survival time at which half of the mutants are sacrificed or die due to illness is 110 days

neoplasm

increased T cell derived lymphoma incidence ( J:47667 )

• 100% incidence of thymoma

• tumorigenesis is accelerated compared to mice hemizygous for Tg(LPV-TAg1135)11Tvd and heterozygous for Rag1

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:47667 )

• 100% incidence of thymoma

• tumorigenesis is accelerated compared to mice hemizygous for Tg(LPV-TAg1135)11Tvd and heterozygous for Rag1

hematopoietic system

increased T cell derived lymphoma incidence ( J:47667 )

• 100% incidence of thymoma

• tumorigenesis is accelerated compared to mice hemizygous for Tg(LPV-TAg1135)11Tvd and heterozygous for Rag1

immune system

increased T cell derived lymphoma incidence ( J:47667 )

• 100% incidence of thymoma

• tumorigenesis is accelerated compared to mice hemizygous for Tg(LPV-TAg1135)11Tvd and heterozygous for Rag1

Allelic Composition	Rag1^tm1Mom/Rag1⁺ Tg(LPV-TAg1135)11Tvd/0
Genetic Background	involves: 129/Sv * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1^tm1Mom mutation (56 available); any Rag1 mutation (133 available)
Tg(LPV-TAg1135)11Tvd mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:47667 )

• survival time at which half of the mutants are sacrificed or die due to illness is 165 days

neoplasm

increased T cell derived lymphoma incidence ( J:47667 )

• 100% incidence of thymoma

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:47667 )

• 100% incidence of thymoma

immune system

increased T cell derived lymphoma incidence ( J:47667 )

• 100% incidence of thymoma

hematopoietic system

increased T cell derived lymphoma incidence ( J:47667 )

• 100% incidence of thymoma

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