Phenotypes associated with this allele
mortality/aging
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• mice die around 13 months of age as in Tg(Vav-BCL2)1Jad mice
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neoplasm
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• diffuse large B cell lymphoma more so than in Tg(Vav-BCL2)1Jad mice
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• more so than in Tg(Vav-BCL2)1Jad mice
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mortality/aging
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• mice die around 13 months of age as in Tg(Vav-BCL2)1Jad mice
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neoplasm
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• diffuse large B cell lymphoma as in Tg(Vav-BCL2)1Jad mice
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• more so than in Tg(Vav-BCL2)1Jad mice
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hematopoietic system
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• GFP+ pre-B cells are absent in the bone marrow
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immune system
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• GFP+ pre-B cells are absent in the bone marrow
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation
(11 available);
any
Cd19 mutation
(56 available)
Tbl1xr1tm1c(EUCOMM)Hmgu mutation
(0 available);
any
Tbl1xr1 mutation
(322 available)
Tg(Vav-BCL2)69Jad mutation
(4 available)
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hematopoietic system
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• large immunoblasts with irregularly shaped nuclei and moderate cytoplasm in lymphoid and other tissues such as kidney and liver when immunized periodically
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• increased number of B220- cells, expressing more CD138 when immunized periodically
• the few remaining B220+ cells mostly (pre)memory B cells (MBs) and not germinal center B cells (GCBs) when immunized periodically
• normal mature B cell numbers in bone marrow when immunized periodically
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• large immunoblasts with irregularly shaped nuclei and moderate cytoplasm mostly outside follicles in red pulp when immunized periodically
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immune system
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• large immunoblasts with irregularly shaped nuclei and moderate cytoplasm in lymphoid and other tissues such as kidney and liver when immunized periodically
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• increased number of B220- cells, expressing more CD138 when immunized periodically
• the few remaining B220+ cells mostly (pre)memory B cells (MBs) and not germinal center B cells (GCBs) when immunized periodically
• normal mature B cell numbers in bone marrow when immunized periodically
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• large immunoblasts with irregularly shaped nuclei and moderate cytoplasm mostly outside follicles in red pulp when immunized periodically
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mortality/aging
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• when immunized periodically
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neoplasm
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• in kidney, lung, liver, intestines and other organs when immunized periodically
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp11cambr mutation
(2 available);
any
Atp11c mutation
(16 available)
Tg(Vav-BCL2)69Jad mutation
(4 available)
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immune system
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• mice exhibit a limited rescue of B cell numbers compared to in Atp11cambr hemizygotes
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• the number of immature B cells is partially recovered compared to in Atp11cambr hemizygotes
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• the number of pre-B cells is partially recovered compared to in Atp11cambr hemizygotes
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hematopoietic system
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• mice exhibit a limited rescue of B cell numbers compared to in Atp11cambr hemizygotes
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• the number of immature B cells is partially recovered compared to in Atp11cambr hemizygotes
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• the number of pre-B cells is partially recovered compared to in Atp11cambr hemizygotes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sppl2am1Anu mutation
(7 available);
any
Sppl2a mutation
(45 available)
Tg(Vav-BCL2)69Jad mutation
(4 available)
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immune system
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• increase in splenic B cells over non mutant controls but lower numbers than in animals carrying the transgene alone
• CD93- IgMlow mature B cells are increased 6.5X but CD93+ IgMhigh T1 B cell number is normal
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• levels are about 12% of normal
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• levels are about 12% of normal
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hematopoietic system
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• increase in splenic B cells over non mutant controls but lower numbers than in animals carrying the transgene alone
• CD93- IgMlow mature B cells are increased 6.5X but CD93+ IgMhigh T1 B cell number is normal
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• levels are about 12% of normal
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• levels are about 12% of normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rragcem1Efe mutation
(0 available);
any
Rragc mutation
(18 available)
Tg(Vav-BCL2)69Jad mutation
(4 available)
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neoplasm
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• mice show a significant delay in follicular lymphoma (FL) and high-grade lymphoma development relative to mice carrying the transgene on a wild-type background; all tumors display pathognomonic features of FL and a similar Ki67 proliferative index in spleen
• although mice show a reduced incidence of FL when sacrificed at 250 days, the incidence, grade, tumor burden and PD1+ microenvironment of FL at euthanasia are similar to those in mice carrying the transgene on a wild-type background
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immune system
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• both unimmunized and SRBC-immunized mice exhibit a lower number of GC B cells in spleen than control mice carrying the transgene on a wild-type background
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• mice exhibit a smaller spontaneous GC formation in spleen than mice carrying the transgene on a wild-type background
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• mice exhibit delayed development of autoimmune glomerulonephritis with a lower number of IgG1+ deposits in the kidney than mice carrying the transgene on a wild-type background
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hematopoietic system
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• both unimmunized and SRBC-immunized mice exhibit a lower number of GC B cells in spleen than control mice carrying the transgene on a wild-type background
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• mice exhibit a smaller spontaneous GC formation in spleen than mice carrying the transgene on a wild-type background
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Vav-BCL2)69Jad mutation
(4 available)
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mortality/aging
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• mice die around 13 months of age
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immune system
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• the total number of B cells that undergo class switching is 50-fold higher than in wild-type mice
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• 22 of 23 clones isolated from class-switching cells harbor on average about 6 somatic mutations compared to in wild-type cells where no mutations are found
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• the ratio of CD4 cells per B cell is 25% to 50% lower than in wild-type mice
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• 5-fold higher in the spleen at 18 weeks
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• mice exhibit higher splenic T cell numbers than in wild-type and Tg(BCL2)22Wehi or Tg(BCL2)36Wehi mice
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• the increase in CD4+ T cells is greater than the increase in CD8+ T cells
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• the increase in CD4+ T cells is greater than the increase in CD8+ T cells
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• mice exhibit a larger pool of cycling B cells with a germinal center phenotype than in wild-type mice
• however, expansion of germinal centers is dependent on CD4 T cell help
• at 18 weeks, mice exhibit an increased in germinal center size and number compared to in wild-type mice
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• at 40 weeks, 15% to 25% of mice develop autoimmune glomerulonephritis
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neoplasm
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• 12% of mice develop plasma cell tumors
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• less than 10% of mice develop lymphoblastic lymphomas
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• in less than 10% of mice
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• less than 10% of mice develop large cell B lymphomas
(J:88565)
• diffuse large B cell lymphoma
(J:228913)
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• at 18 months, 37% to 50% of mice develop monoclonal follicular lymphoma
(J:88565)
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• in less than 10% of mice
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renal/urinary system
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• mice develop hypercellular glomeruli that contain amorphous, eosinophilic deposits
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• most capillaries are no longer patent
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• at 40 weeks, 15% to 25% of mice develop autoimmune glomerulonephritis
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• Bowman epithelium proliferates to form crescents in the most advanced cases
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endocrine/exocrine glands
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• in less than 10% of mice
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hematopoietic system
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• the total number of B cells that undergo class switching is 50-fold higher than in wild-type mice
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• 22 of 23 clones isolated from class-switching cells harbor on average about 6 somatic mutations compared to in wild-type cells where no mutations are found
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• the ratio of CD4 cells per B cell is 25% to 50% lower than in wild-type mice
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• 5-fold higher in the spleen at 18 weeks
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• mice exhibit higher splenic T cell numbers than in wild-type and Tg(BCL2)22Wehi or Tg(BCL2)36Wehi mice
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• the increase in CD4+ T cells is greater than the increase in CD8+ T cells
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• the increase in CD4+ T cells is greater than the increase in CD8+ T cells
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• mice exhibit a larger pool of cycling B cells with a germinal center phenotype than in wild-type mice
• however, expansion of germinal centers is dependent on CD4 T cell help
• at 18 weeks, mice exhibit an increased in germinal center size and number compared to in wild-type mice
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cardiovascular system
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• most capillaries are no longer patent
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growth/size/body
Analysis Tools