Phenotypes associated with this allele

• Allele Symbol: Igf1r^tm2Arge
• Allele Name: targeted mutation 2, Argiris Efstratiadis
• Allele ID: MGI:2389580
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Igf1r^tm2Arge/Igf1r^+ Tg(Tek-cre)1Ywa/0	B6.Cg-Tg(Tek-cre)1Ywa Igf1r^tm2Arge	MGI:5568546
cn2	Igf1r^tm2Arge/Igf1r^tm2Arge Tg(BGLAP-cre)1Clem/0	involves: 129 * FVB/N	MGI:2651814
cn3	Eef1a1^tm1(Kras*)Arge/Eef1a1^+ Igf1r^tm2Arge/Igf1r^tm2Arge Wap^tm1(cre)Arge/Wap^+	involves: 129S1/Sv	MGI:3837711
cn4	Eef1a1^tm1(Kras*)Arge/Eef1a1^+ Igf1r^tm2Arge/Igf1r^+ Wap^tm1(cre)Arge/Wap^+	involves: 129S1/Sv	MGI:3837708
cn5	Igf1r^tm1Arge/Igf1r^tm2Arge Tg(Camk2a-cre)2Szi/0	involves: 129S/SvEv * C57BL/6J * CBA	MGI:3038640

Genotype
MGI:5568546

cn1

• Allelic Composition: Igf1r^tm2Arge/Igf1r⁺; Tg(Tek-cre)1Ywa/0
• Genetic Background: B6.Cg-Tg(Tek-cre)1Ywa Igf1r^tm2Arge

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal vascular endothelial cell physiology ( J:208523 )

♂ • blunted endothelial regeneration after arterial injury compared with wild-type cells

abnormal vascular wound healing ( J:208523 )

♂ • blunted endothelial regeneration after arterial injury compared with wild-type cells

homeostasis/metabolism

abnormal vascular wound healing ( J:208523 )

♂ • blunted endothelial regeneration after arterial injury compared with wild-type cells

Genotype
MGI:2651814

cn2

• Allelic Composition: Igf1r^tm2Arge/Igf1r^tm2Arge; Tg(BGLAP-cre)1Clem/0
• Genetic Background: involves: 129 * FVB/N

skeleton

abnormal skeleton morphology ( J:80190 )

• phenotype is quantitatively similar, but less pronounced in males compared to females

thin neurocranium ( J:80190 )

• calvarial cortical thickness is reduced to ~80% of control

decreased osteoclast cell number ( J:80190 )

• significant reduction in number (67-69%) per bone perimeter is seen relative to controls

decreased osteoblast cell number ( J:80190 )

• significant reduction in number (67-69%) per bone perimeter is seen relative to controls

abnormal trabecular bone morphology ( J:80190 )

• trabecular separation is increased by 44% compared to controls

• in secondary spongiosa of distal femur in 6-week old females, trabecular separation is increased; trabecular connectivity is 35% lower than normal

decreased trabecular bone volume ( J:80190 )

• trabecular bone volume is decreased by 46%

• in secondary spongiosa of distal femur in 6-week old females, cancellous bone volume is ~24% lower than controls

decreased bone trabecula number ( J:80190 )

• trabecular number is decreased by 29%

decreased trabecular bone thickness ( J:80190 )

• trabecular thickness is decreased by 25%

abnormal skeleton physiology ( J:80190 )

• phenotype is quantitatively similar, but less pronounced in males compared to females

abnormal osteoblast physiology ( J:80190 )

• increase in osteoclast erosion surface accompanies increase in osteoid

abnormal osteoclast physiology ( J:80190 )

• amount of osteoid is significantly increased in female mutants at 6-weeks

decreased bone mineralization ( J:80190 )

• mineral apposition rate is impaired in 6-week old females

decreased bone ossification ( J:80190 )

• in 3-week old females, epiphyseal bone formation rate is reduced to ~42% of control mice

craniofacial

thin neurocranium ( J:80190 )

• calvarial cortical thickness is reduced to ~80% of control

immune system

decreased osteoclast cell number ( J:80190 )

• significant reduction in number (67-69%) per bone perimeter is seen relative to controls

abnormal osteoclast physiology ( J:80190 )

• amount of osteoid is significantly increased in female mutants at 6-weeks

hematopoietic system

decreased osteoclast cell number ( J:80190 )

• significant reduction in number (67-69%) per bone perimeter is seen relative to controls

abnormal osteoclast physiology ( J:80190 )

• amount of osteoid is significantly increased in female mutants at 6-weeks

cellular

abnormal osteoblast physiology ( J:80190 )

• increase in osteoclast erosion surface accompanies increase in osteoid

Genotype
MGI:3837711

cn3

• Allelic Composition: Eef1a1^{tm1(Kras*)Arge}/Eef1a1⁺; Igf1r^tm2Arge/Igf1r^tm2Arge; Wap^tm1(cre)Arge/Wap⁺
• Genetic Background: involves: 129S1/Sv

mortality/aging

decreased tumor-free survival time ( J:146290 )

• median tumor free survival of lactating females is 101 days from the first parturition

neoplasm

increased mammary gland tumor incidence ( J:146290 )

• female mice develop mammary gland tumors after 3 pregnancies with an 11-fold increase in latency compared to in Eef1a1^{tm1(Kras*)Arge} Wap^tm1(cre)Arge heterozygotes

• median tumor free survival of lactating females is 101 days from the first parturition

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:146290 )

• female mice develop mammary gland tumors after 3 pregnancies with an 11-fold increase in latency compared to in Eef1a1^{tm1(Kras*)Arge} Wap^tm1(cre)Arge heterozygotes

• median tumor free survival of lactating females is 101 days from the first parturition

integument

increased mammary gland tumor incidence ( J:146290 )

• female mice develop mammary gland tumors after 3 pregnancies with an 11-fold increase in latency compared to in Eef1a1^{tm1(Kras*)Arge} Wap^tm1(cre)Arge heterozygotes

• median tumor free survival of lactating females is 101 days from the first parturition

Genotype
MGI:3837708

cn4

• Allelic Composition: Eef1a1^{tm1(Kras*)Arge}/Eef1a1⁺; Igf1r^tm2Arge/Igf1r⁺; Wap^tm1(cre)Arge/Wap⁺
• Genetic Background: involves: 129S1/Sv

mortality/aging

decreased tumor-free survival time ( J:146290 )

• median tumor free survival of lactating females is 43 days from the first parturition

neoplasm

increased mammary gland tumor incidence ( J:146290 )

• female mice develop mammary gland tumors with a 5-fold increase in latency compared to in Eef1a1^{tm1(Kras*)Arge} Wap^tm1(cre)Arge heterozygotes

• median tumor free survival of lactating females is 43 days from the first parturition

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:146290 )

• female mice develop mammary gland tumors with a 5-fold increase in latency compared to in Eef1a1^{tm1(Kras*)Arge} Wap^tm1(cre)Arge heterozygotes

• median tumor free survival of lactating females is 43 days from the first parturition

integument

increased mammary gland tumor incidence ( J:146290 )

• female mice develop mammary gland tumors with a 5-fold increase in latency compared to in Eef1a1^{tm1(Kras*)Arge} Wap^tm1(cre)Arge heterozygotes

• median tumor free survival of lactating females is 43 days from the first parturition

Genotype
MGI:3038640

cn5

• Allelic Composition: Igf1r^tm1Arge/Igf1r^tm2Arge; Tg(Camk2a-cre)2Szi/0
• Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA

nervous system

decreased oligodendrocyte progenitor number ( J:88198 )

• oligodendrocyte progenitor cells fail to proliferate and an increase in apoptosis is seen in the middle region of the corpus callosum following cuprizone exposure

abnormal CNS glial cell morphology ( J:88198 )

• micoglia/macrophages persist in the middle region of the corpus callosum in mutants 9 weeks after cuprizone exposure but not in wild-types

abnormal oligodendrocyte morphology ( J:88198 )

• mature oligodendrocyte fail to regenerate in the middle region of the corpus callosum following cuprizone exposure

abnormal myelination ( J:88198 )

• 9 and 14 weeks after cuprizone induced demyelination, remyelination is absent in the middle region of the corpus callosum of the forebrain in mutants

• 9 and 14 weeks after cuprizone induced demyelination, remyelination has occurred in the extreme ventral and dorsal edges of the callosum in mutants and throughout the corpus callosum in wild-types

• prior to cuprizone treatment myelination is normal in mutants

cellular

decreased oligodendrocyte progenitor number ( J:88198 )

• oligodendrocyte progenitor cells fail to proliferate and an increase in apoptosis is seen in the middle region of the corpus callosum following cuprizone exposure