All Phenotypes Hoxa11<tm1Mrc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hoxa11^tm1Mrc
targeted mutation 1, Mario R Capecchi
MGI:2389126

Summary

19 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc	Not Specified	MGI:3810823
ht2	Hoxa11^tm1Mrc/Hoxa11⁺	Not Specified	MGI:3810824
cx3	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxd11^tm1Mrc/Hoxd11⁺	involves: 129S7/SvEvBrd	MGI:3810825
cx4	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxd11^tm1Mrc/Hoxd11^tm1Mrc	involves: 129S7/SvEvBrd	MGI:3810827
cx5	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxd11^tm1Mrc/Hoxd11^tm1Mrc	involves: 129S7/SvEvBrd	MGI:3810837
cx6	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxd11^tm1Mrc/Hoxd11⁺	involves: 129S7/SvEvBrd	MGI:3810838
cx7	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxc11^tm1Mrc/Hoxc11⁺ Hoxd11^tm1Mrc/Hoxd11⁺	involves: 129S7/SvEvBrd	MGI:3814871
cx8	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxc11^tm1Mrc/Hoxc11⁺ Hoxd11^tm1Mrc/Hoxd11⁺	involves: 129S7/SvEvBrd	MGI:3814872
cx9	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxc11^tm1Mrc/Hoxc11^tm1Mrc Hoxd11^tm1Mrc/Hoxd11⁺	involves: 129S7/SvEvBrd	MGI:3814873
cx10	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxc11^tm1Mrc/Hoxc11⁺ Hoxd11^tm1Mrc/Hoxd11^tm1Mrc	involves: 129S7/SvEvBrd	MGI:3814874
cx11	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxc11^tm1Mrc/Hoxc11^tm1Mrc Hoxd11^tm1Mrc/Hoxd11^tm1Mrc	involves: 129S7/SvEvBrd	MGI:3814876
cx12	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxc11^tm1Mrc/Hoxc11^tm1Mrc	involves: 129S7/SvEvBrd	MGI:3814878
cx13	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxc11^tm1Mrc/Hoxc11^tm1Mrc Hoxd11^tm1Mrc/Hoxd11^tm1Mrc	involves: 129S7/SvEvBrd	MGI:3814879
cx14	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxc11^tm1Mrc/Hoxc11⁺ Hoxd11^tm1Mrc/Hoxd11^tm1Mrc	involves: 129S7/SvEvBrd	MGI:3814881
cx15	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxc11^tm1Mrc/Hoxc11^tm1Mrc Hoxd11^tm1Mrc/Hoxd11⁺	involves: 129S7/SvEvBrd	MGI:3814882
cx16	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxd11^tm1Mrc/Hoxd11^{tm2.1(Hoxd11)Mrc}	involves: 129S7/SvEvBrd * BALB/cJ	MGI:3810836
cx17	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxd11^{tm2.1(Hoxd11)Mrc}/Hoxd11⁺	involves: BALB/cJ	MGI:3810830
cx18	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxd11^{tm2.1(Hoxd11)Mrc}/Hoxd11^{tm2.1(Hoxd11)Mrc}	involves: BALB/cJ	MGI:3810831
cx19	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxd11^{tm2.1(Hoxd11)Mrc}/Hoxd11^{tm2.1(Hoxd11)Mrc}	involves: BALB/cJ	MGI:3810839

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa11^tm1Mrc mutation (0 available); any Hoxa11 mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

female infertility ( J:78766 )

reduced male fertility ( J:78766 )

• 3 of 9 male mice are fertile

skeleton

short radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice

increased diameter of radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice

increased diameter of ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice

increased lumbar vertebrae number ( J:78766 )

• 7 instead of 6

limbs/digits/tail

short radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice

increased diameter of radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice

increased diameter of ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa11^tm1Mrc mutation (0 available); any Hoxa11 mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:78766 )

N	• mice exhibit a normal number of lumbar vertebrae

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxd11^tm1Mrc/Hoxd11⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa11^tm1Mrc mutation (0 available); any Hoxa11 mutation (11 available)
Hoxd11^tm1Mrc mutation (0 available); any Hoxd11 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

increased lumbar vertebrae number ( J:78766 )

• 7 instead of 6

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxd11^tm1Mrc/Hoxd11^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

increased lumbar vertebrae number ( J:78766 )

• 7 instead of 6

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxd11^tm1Mrc/Hoxd11^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

short radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice and Hoxa11^tm1Mrc homozygotes

increased diameter of radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice and Hoxa11^tm1Mrc homozygotes

short ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice and Hoxa11^tm1Mrc homozygotes

increased diameter of ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice and Hoxa11^tm1Mrc homozygotes

increased lumbar vertebrae number ( J:78766 )

• 8 instead of 6

renal/urinary system

renal hypoplasia ( J:88686 )

• bilateral kidney hypoplasia present at birth

single kidney ( J:88686 )

• occasionally seen

abnormal ureter development ( J:88686 )

• at E13.5 the ureter's route to the kidney is circuitous and abnormal; transversing anteriorly around the kidney to the lateral side before entering the kidney

limbs/digits/tail

short radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice and Hoxa11^tm1Mrc homozygotes

increased diameter of radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice and Hoxa11^tm1Mrc homozygotes

short ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice and Hoxa11^tm1Mrc homozygotes

increased diameter of ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice and Hoxa11^tm1Mrc homozygotes

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxd11^tm1Mrc/Hoxd11⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

fused carpal bones ( J:78766 )

• the proximal carpal bones, navicular lunate and psiform are fused in all mice

short radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice and Hoxa11^tm1Mrc homozygotes

increased diameter of radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice and Hoxa11^tm1Mrc homozygotes

short ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice and Hoxa11^tm1Mrc homozygotes

increased diameter of ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice and Hoxa11^tm1Mrc homozygotes

increased lumbar vertebrae number ( J:78766 )

• 7 instead of 6

limbs/digits/tail

fused carpal bones ( J:78766 )

• the proximal carpal bones, navicular lunate and psiform are fused in all mice

short radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice and Hoxa11^tm1Mrc homozygotes

increased diameter of radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice and Hoxa11^tm1Mrc homozygotes

short ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice and Hoxa11^tm1Mrc homozygotes

increased diameter of ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice and Hoxa11^tm1Mrc homozygotes

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxc11^tm1Mrc/Hoxc11⁺ Hoxd11^tm1Mrc/Hoxd11⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa11^tm1Mrc mutation (0 available); any Hoxa11 mutation (11 available)
Hoxc11^tm1Mrc mutation (0 available); any Hoxc11 mutation (14 available)
Hoxd11^tm1Mrc mutation (0 available); any Hoxd11 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal reproductive system morphology ( J:88686 )

• show reproductive defects similar to those of mice homozygous for Hoxa11^tm1Mrc

female infertility ( J:88686 )

male infertility ( J:88686 )

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxc11^tm1Mrc/Hoxc11⁺ Hoxd11^tm1Mrc/Hoxd11⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal reproductive system morphology ( J:88686 )

• show reproductive defects similar to those of mice homozygous for Hoxa11^tm1Mrc

female infertility ( J:88686 )

male infertility ( J:88686 )

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxc11^tm1Mrc/Hoxc11^tm1Mrc Hoxd11^tm1Mrc/Hoxd11⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal reproductive system morphology ( J:88686 )

• show reproductive defects similar to those of mice homozygous for Hoxa11^tm1Mrc

female infertility ( J:88686 )

male infertility ( J:88686 )

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxc11^tm1Mrc/Hoxc11⁺ Hoxd11^tm1Mrc/Hoxd11^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal reproductive system morphology ( J:88686 )

• show reproductive defects similar to those of mice homozygous for Hoxa11^tm1Mrc

female infertility ( J:88686 )

male infertility ( J:88686 )

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxc11^tm1Mrc/Hoxc11^tm1Mrc Hoxd11^tm1Mrc/Hoxd11^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal kidney development ( J:88686 )

• at E11.5 increased apoptosis is seen in the condensed blastemal mesenchyme

• absence of metanephric kidney development at E13.5 and birth

increased metanephric mesenchyme apoptosis ( J:88686 )

• at E11.5 increased apoptosis is seen in the condensed blastemal mesenchyme

absent metanephros ( J:88686 )

• absence of metanephric kidney development at E13.5 and birth

absent ureteric bud ( J:88686 )

• absence of bud formation at E11.5

cellular

increased metanephric mesenchyme apoptosis ( J:88686 )

• at E11.5 increased apoptosis is seen in the condensed blastemal mesenchyme

embryo

increased metanephric mesenchyme apoptosis ( J:88686 )

• at E11.5 increased apoptosis is seen in the condensed blastemal mesenchyme

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxc11^tm1Mrc/Hoxc11^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal hypoplasia ( J:88686 )

• bilateral kidney hypoplasia that is less severe than in Hoxa11^tm1Mrc Hoxd11^tm1Mrc double homozygotes

single kidney ( J:88686 )

• occasionally seen

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxc11^tm1Mrc/Hoxc11^tm1Mrc Hoxd11^tm1Mrc/Hoxd11^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal hypoplasia ( J:88686 )

• hypoplasia is more severe than in mice with 4 mutant alleles

ectopic kidney ( J:88686 )

• kidneys, when present, are in a more caudal and ventral location

single kidney ( J:88686 )

• occasionally seen

• more frequent than in mice with 4 mutant alleles

abnormal ureteric bud invasion ( J:88686 )

• at E11.5, the bud forms but frequently migrates away from the metanephric mesenchyme

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxc11^tm1Mrc/Hoxc11⁺ Hoxd11^tm1Mrc/Hoxd11^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal hypoplasia ( J:88686 )

• hypoplasia is more severe than in mice with 4 mutant alleles

ectopic kidney ( J:88686 )

• kidneys, when present, are in a more caudal and ventral location

single kidney ( J:88686 )

• occasionally seen

• more frequent than in mice with 4 mutant alleles

abnormal ureteric bud invasion ( J:88686 )

• at E11.5, the bud forms but frequently migrates away from the metanephric mesenchyme

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxc11^tm1Mrc/Hoxc11^tm1Mrc Hoxd11^tm1Mrc/Hoxd11⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal hypoplasia ( J:88686 )

• hypoplasia is more severe than in mice with 4 mutant alleles

ectopic kidney ( J:88686 )

• kidneys, when present, are in a more caudal and ventral location

single kidney ( J:88686 )

• occasionally seen

• more frequent than in mice with 4 mutant alleles

abnormal ureteric bud invasion ( J:88686 )

• at E11.5, the bud forms but frequently migrates away from the metanephric mesenchyme

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxd11^tm1Mrc/Hoxd11^{tm2.1(Hoxd11)Mrc}
Genetic Background	involves: 129S7/SvEvBrd * BALB/cJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

fused carpal bones ( J:78766 )

• the proximal carpal bones and navicular lunate are fused in four of five mice

short radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice

increased diameter of radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice

short ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice

increased diameter of ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice

increased lumbar vertebrae number ( J:78766 )

• 7 instead of 6

limbs/digits/tail

fused carpal bones ( J:78766 )

• the proximal carpal bones and navicular lunate are fused in four of five mice

short radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice

increased diameter of radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice

short ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice

increased diameter of ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxd11^{tm2.1(Hoxd11)Mrc}/Hoxd11⁺
Genetic Background	involves: BALB/cJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa11^tm1Mrc mutation (0 available); any Hoxa11 mutation (11 available)
Hoxd11^{tm2.1(Hoxd11)Mrc} mutation (0 available); any Hoxd11 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

female infertility ( J:78766 )

reduced male fertility ( J:78766 )

• 4 of 10 mice are fertile

skeleton

skeleton phenotype ( J:78766 )

N	• mice exhibit a normal number of lumbar vertebrae

short radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice but not as severely affected as in Hoxa11^tm1Mrc homozygotes

increased diameter of radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice but not as severely affected as in Hoxa11^tm1Mrc homozygotes

short ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice but not as severely affected as in Hoxa11^tm1Mrc homozygotes

increased diameter of ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice but not as severely affected as in Hoxa11^tm1Mrc homozygotes

limbs/digits/tail

short radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice but not as severely affected as in Hoxa11^tm1Mrc homozygotes

increased diameter of radius ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice but not as severely affected as in Hoxa11^tm1Mrc homozygotes

short ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice but not as severely affected as in Hoxa11^tm1Mrc homozygotes

increased diameter of ulna ( J:78766 )

• forearm bones are shorter and broader than in wild-type mice but not as severely affected as in Hoxa11^tm1Mrc homozygotes

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11^tm1Mrc Hoxd11^{tm2.1(Hoxd11)Mrc}/Hoxd11^{tm2.1(Hoxd11)Mrc}
Genetic Background	involves: BALB/cJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

female infertility ( J:78766 )

male infertility ( J:78766 )

skeleton

skeleton phenotype ( J:78766 )

N	• mice exhibit a normal number of lumbar vertebrae

limbs/digits/tail

limbs/digits/tail phenotype ( J:78766 )

N	• forearm bones are normal

Allelic Composition	Hoxa11^tm1Mrc/Hoxa11⁺ Hoxd11^{tm2.1(Hoxd11)Mrc}/Hoxd11^{tm2.1(Hoxd11)Mrc}
Genetic Background	involves: BALB/cJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:78766 )

N	• mice exhibit a normal number of lumbar vertebrae

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