Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat6tm1Aki mutation
(7 available);
any
Stat6 mutation
(51 available)
Tg(KRT14-CASP1)1Miz mutation
(0 available)
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behavior/neurological
hematopoietic system
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• no detectable levels of IgE
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homeostasis/metabolism
immune system
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• no detectable levels of IgE
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• mice develop cutaneous skin changes around 8 weeks of age that develop into pruritic dermatitis
• reduction in the number of accumulated mast cells compared to single Tg(KRT14-CASP1)1Miz mice, but still higher levels than in wild-type mice
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integument
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• mice develop cutaneous skin changes around 8 weeks of age that develop into pruritic dermatitis
• reduction in the number of accumulated mast cells compared to single Tg(KRT14-CASP1)1Miz mice, but still higher levels than in wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il18tm1Aki mutation
(3 available);
any
Il18 mutation
(29 available)
Tg(KRT14-CASP1)1Miz mutation
(0 available)
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hematopoietic system
immune system
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N |
• diminution in the number of cutaneous mast cells and serum histamine levels compared to single Tg(KRT14-CASP1)1Miz mice
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integument
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N |
• mice do not exhibit frequent skin scratching nor dermatitis by 6 months of age
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1atm1Yiw mutation
(0 available);
any
Il1a mutation
(29 available)
Il1btm1Yiw mutation
(0 available);
any
Il1b mutation
(24 available)
Tg(KRT14-CASP1)1Miz mutation
(0 available)
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immune system
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• late onset of skin alterations which are similar to, but milder than, in single Tg(KRT14-CASP1)1Miz mutants
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integument
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• late onset of skin alterations which are similar to, but milder than, in single Tg(KRT14-CASP1)1Miz mutants
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
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• more than 80% of mice die within 6 days after Propionibacterium acnes administration compared to none of wild-type mice
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growth/size/body
integument
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• keratinocytes in the lesions show eosinophilic necrosis with nuclear condensation, indicating apoptosis
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• mice eventually develop papillomatosis with intercellular edema
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• severe erosive dermatitis is seen at 8 weeks of age, followed by reepithalization and lichenoid changes
(J:78602)
• mast cell number is increased in the dermal infiltrates
(J:78602)
• mice exhibit chronic active dermatitis at 8 weeks of age from 8 weeks of age, mice develop focal dermatitis around their eyes, which rapidly develops into severe erosive dermatitis and extends onto face, ear, neck, neck, trunk, and legs within a few weeks
(J:79706)
• dermis of ulcers is characterized by infiltration of many mononuclear cells
(J:79706)
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• loss of facial hair and extremity hair is seen by 16 weeks of age
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• mice eventually develop papillomatosis with intercellular edema
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• mice eventually exhibit parakeratotic scale-crust in the epidermis
(J:78602)
• seen by 10 weeks of age
(J:79706)
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• mice eventually develop prominent acanthosis
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• mice develop inflammatory skin lesion with high concentration of IgE
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• occasional skin ulcers are seen at 8 weeks of age and although reepithalization occurs, erosion occurs and ulcers relapse
• after 16 weeks of age, multiple skin ulcers form and the ear and eyelids are deformed
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• thick epidermis around ulcers at 10 weeks of age shows psoriasis-like changes including parakeratosis
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immune system
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• proportion of neutrophils, as determined by Gr-1+ Mac-1+ cells, is elevated in the spleen
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• splenic lymphocytes show a lower proportion of T cells compared to wild-type mice
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• isolated CD4+ T cells produce more IL-3, Il-4, and IL-5, but less IFN-gamma, in response to immobilized anti-CD3, compared to wild-type mice
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• high concentration of IL-18 in the circulation at 4 weeks after birth, that gradually increases with growth
(J:79706)
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• severe erosive dermatitis is seen at 8 weeks of age, followed by reepithalization and lichenoid changes
(J:78602)
• mast cell number is increased in the dermal infiltrates
(J:78602)
• mice exhibit chronic active dermatitis at 8 weeks of age from 8 weeks of age, mice develop focal dermatitis around their eyes, which rapidly develops into severe erosive dermatitis and extends onto face, ear, neck, neck, trunk, and legs within a few weeks
(J:79706)
• dermis of ulcers is characterized by infiltration of many mononuclear cells
(J:79706)
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• P. acnes treated mice develop fatal hepatitis and show an increase in IFN-gamma levels following P. acnes infection that peaks at 4 days after infection that is not seen in wild-type mice
• treatment with a neutralizing anti-IL18 antibody completely rescues mice from fatal liver injury
• susceptibility to P. acnes induced liver injury is not different before and after the onset of skin changes
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• more than 80% of mice die within 6 days after Propionibacterium acnes administration compared to none of wild-type mice
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homeostasis/metabolism
cellular
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• keratinocytes in the lesions show eosinophilic necrosis with nuclear condensation, indicating apoptosis
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behavior/neurological
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• mice frequently scratch their skin, particularly the skin lesion
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hematopoietic system
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• proportion of neutrophils, as determined by Gr-1+ Mac-1+ cells, is elevated in the spleen
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• splenic lymphocytes show a lower proportion of T cells compared to wild-type mice
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• isolated CD4+ T cells produce more IL-3, Il-4, and IL-5, but less IFN-gamma, in response to immobilized anti-CD3, compared to wild-type mice
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Analysis Tools