Phenotypes associated with this allele

• Allele Symbol: Lipe^tm1Rze
• Allele Name: targeted mutation 1, Rudolf Zechner
• Allele ID: MGI:2388334
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lipe^tm1Rze/Lipe^tm1Rze	involves: 129P2/OlaHsd	MGI:3838170
hm2	Lipe^tm1Rze/Lipe^tm1Rze	involves: 129P2/OlaHsd * C57BL/6J	MGI:3838169

Genotype
MGI:3838170

hm1

• Allelic Composition: Lipe^tm1Rze/Lipe^tm1Rze
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating glucose level ( J:84822 )

• increased by 55% in fasted males compared to controls

decreased circulating insulin level ( J:84822 )

• decreased by 63% in fasted males compared to controls

decreased circulating free fatty acids level ( J:84822 )

• decreased by about 40% in fasted males compared to controls

decreased circulating triglyceride level ( J:84822 )

• decreased by about 70% in fasted males compared to controls

abnormal hepatic glucose production ( J:84822 )

• increased suppression of hepatic glucose production by hyperinsulinemic conditions compared to controls

decreased circulating adiponectin level ( J:84822 )

• plasma adiponectin levels are decreased by about 60% compared to controls

decreased liver triglyceride level ( J:84822 )

liver/biliary system

decreased liver triglyceride level ( J:84822 )

Genotype
MGI:3838169

hm2

• Allelic Composition: Lipe^tm1Rze/Lipe^tm1Rze
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

cardiovascular system

decreased cardiac muscle triglyceride level ( J:74644 )

• decreased by about 70% in cardiac muscle compared to controls

homeostasis/metabolism

abnormal lipid level ( J:74644 )

• diglycerides accumulate in brown fat, white fat, testes, skeletal muscle, and cardiac muscle

abnormal fatty acids level ( J:74644 )

• shift from reduced short chain fatty acids to elevated long chain fatty acids is seen in the white fat

abnormal triglyceride level ( J:74644 )

• in white fat the fraction of triglycerides with shorter chain fatty acids is decreased and the fraction with longer chain fatty acids is increased

decreased cardiac muscle triglyceride level ( J:74644 )

• decreased by about 70% in cardiac muscle compared to controls

decreased liver triglyceride level ( J:74644 )

• decreased by about 90% compared to controls

increased triglyceride level ( J:74644 )

• increased by about 30% in brown fat compared to controls

abnormal metabolism ( J:74644 )

• decrease in the formation of free fatty acids in white and brown fat, skeletal and cardiac muscle, liver, and brain

• reduced capacity for hydrolysis of diglycerides in all tissue examined

• reduced capacity for hydrolysis of triglycerides only in white fat and testes

adipose tissue

abnormal brown adipose tissue physiology ( J:74644 )

• diglycerides accumulate in brown fat

abnormal white adipose tissue physiology ( J:74644 )

• diglycerides accumulate in white fat

• the fraction of triglycerides with shorter chain fatty acids is decreased and the fraction with longer chain fatty acids is increased

muscle

decreased cardiac muscle triglyceride level ( J:74644 )

• decreased by about 70% in cardiac muscle compared to controls

liver/biliary system

decreased liver triglyceride level ( J:74644 )

• decreased by about 90% compared to controls