All Phenotypes Cd79a<tm1.1Cgn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cd79a^tm1.1Cgn
targeted mutation 1.1, University of Cologne
MGI:2388326

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn	involves: 129P2/OlaHsd	MGI:3722628
hm2	Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn	involves: 129P2/OlaHsd * C57BL/6	MGI:3813546
cx3	Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn Cd79b^tm1Gzmn/Cd79b^tm1Gzmn	involves: 129P2/OlaHsd	MGI:5301878
cx4	Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn Cd79b^tm1Gzmn/Cd79b⁺	involves: 129P2/OlaHsd	MGI:5301880
cx5	Cd79a^tm1.1Cgn/Cd79a⁺ Cd79b^tm1Gzmn/Cd79b^tm1Gzmn	involves: 129P2/OlaHsd	MGI:5301881
cx6	Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn Cd79b^tm2.1Mnz/Cd79b^tm2.1Mnz	involves: 129/Sv * 129P2/OlaHsd * C57BL/6	MGI:3813551
cx7	Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn Cd79b^tm3Mnz/Cd79b^tm3Mnz	involves: 129/Sv * 129P2/OlaHsd * C57BL/6	MGI:3768661
cx8	Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn Cd79b^tm1Gzmn/Cd79b^tm1Gzmn	involves: 129/Sv * 129P2/OlaHsd * C57BL/6	MGI:3722627

Allelic Composition	Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79a^tm1.1Cgn mutation (0 available); any Cd79a mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased B-1a cell number ( J:124400 )

immune system

decreased B-1a cell number ( J:124400 )

Allelic Composition	Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79a^tm1.1Cgn mutation (0 available); any Cd79a mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased mature B cell number ( J:71100 )

• there is about a 30% reduction in the number of recirculating B cells found in the bone marrow

decreased B-1 B cell number ( J:71100 )

• B-1 B cells numbers are reduced by 10-fold in the peritoneum

decreased marginal zone B cell number ( J:71100 )

• marginal zone B cell numbers are found at 5?25% of wild-type controls

abnormal B cell activation ( J:71100 )

• production of antibodies to T cell dependent antigens is impaired

• B cells activated in vitro exhibit a stronger calcium response with a delayed maximum in comparison to wild-type controls

decreased IgG1 level ( J:71100 )

• IgG1 levels are reduced in the serum by almost 10-fold

• when immunized with T cell dependent antigen, production of antigen-specific IgG1 is consistently lower than controls

hematopoietic system

decreased mature B cell number ( J:71100 )

• there is about a 30% reduction in the number of recirculating B cells found in the bone marrow

decreased B-1 B cell number ( J:71100 )

• B-1 B cells numbers are reduced by 10-fold in the peritoneum

decreased marginal zone B cell number ( J:71100 )

• marginal zone B cell numbers are found at 5?25% of wild-type controls

abnormal B cell activation ( J:71100 )

• production of antibodies to T cell dependent antigens is impaired

• B cells activated in vitro exhibit a stronger calcium response with a delayed maximum in comparison to wild-type controls

decreased IgG1 level ( J:71100 )

• IgG1 levels are reduced in the serum by almost 10-fold

• when immunized with T cell dependent antigen, production of antigen-specific IgG1 is consistently lower than controls

Allelic Composition	Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn Cd79b^tm1Gzmn/Cd79b^tm1Gzmn
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79a^tm1.1Cgn mutation (0 available); any Cd79a mutation (22 available)
Cd79b^tm1Gzmn mutation (1 available); any Cd79b mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:179254 )

• mice exhibit impaired pre-B and later stage B cell development unlike either single homozygote

increased pro-B cell number ( J:179254 )

decreased B cell number ( J:179254 )

• IgM+ B cells

absent pre-B cells ( J:179254 )

hematopoietic system

abnormal B cell differentiation ( J:179254 )

• mice exhibit impaired pre-B and later stage B cell development unlike either single homozygote

increased pro-B cell number ( J:179254 )

decreased B cell number ( J:179254 )

• IgM+ B cells

absent pre-B cells ( J:179254 )

Allelic Composition	Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn Cd79b^tm1Gzmn/Cd79b⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased pro-B cell number ( J:179254 )

decreased B cell number ( J:179254 )

• IgM+ B cells

decreased pre-B cell number ( J:179254 )

hematopoietic system

increased pro-B cell number ( J:179254 )

decreased B cell number ( J:179254 )

• IgM+ B cells

decreased pre-B cell number ( J:179254 )

Allelic Composition	Cd79a^tm1.1Cgn/Cd79a⁺ Cd79b^tm1Gzmn/Cd79b^tm1Gzmn
Genetic Background	involves: 129P2/OlaHsd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased pro-B cell number ( J:179254 )

decreased B cell number ( J:179254 )

• IgM+ B cells

decreased pre-B cell number ( J:179254 )

hematopoietic system

increased pro-B cell number ( J:179254 )

decreased B cell number ( J:179254 )

• IgM+ B cells

decreased pre-B cell number ( J:179254 )

Allelic Composition	Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn Cd79b^tm2.1Mnz/Cd79b^tm2.1Mnz
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79a^tm1.1Cgn mutation (0 available); any Cd79a mutation (22 available)
Cd79b^tm2.1Mnz mutation (0 available); any Cd79b mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

arrested B cell differentiation ( J:71100 )

• B cell development is blocked in the pro-B cell stage at the fraction C'(BP-1⁺HSA^bright step

absent mature B cells ( J:71100 )

• B cells are absent from the periphery

hematopoietic system

arrested B cell differentiation ( J:71100 )

• B cell development is blocked in the pro-B cell stage at the fraction C'(BP-1⁺HSA^bright step

absent mature B cells ( J:71100 )

• B cells are absent from the periphery

Allelic Composition	Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn Cd79b^tm3Mnz/Cd79b^tm3Mnz
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79a^tm1.1Cgn mutation (0 available); any Cd79a mutation (22 available)
Cd79b^tm3Mnz mutation (1 available); any Cd79b mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:128768 )

N	• unlike in Cd79b^tm3Mnz homozygotes, B cells proliferate in response to BCR cross-linking

Allelic Composition	Cd79a^tm1.1Cgn/Cd79a^tm1.1Cgn Cd79b^tm1Gzmn/Cd79b^tm1Gzmn
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:124400 )

• B cells fail to develop beyond the pro-B cell stage

hematopoietic system

abnormal B cell differentiation ( J:124400 )

• B cells fail to develop beyond the pro-B cell stage

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