Cd79b^tm2.1Mnz
Targeted Allele Detail

Summary

• Symbol: Cd79b^tm2.1Mnz
• Name: CD79B antigen; targeted mutation 2.1, Michel C Nussenzweig
• MGI ID: MGI:2447121
• Synonyms: IgBeta DeltaC
• Gene: Cd79b Location: Chr11:106202167-106205388 bp, - strand Genetic Position: Chr11, 68.89 cM
• Alliance: Cd79b^tm2.1Mnz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66840
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Nucleotide substitutions
• Mutation details: The intronic floxed neo cassette was excised from Cd79b^tm2Mnz via cre mediated recombination. The nonsense mutation at codon 184 remained, precluding the translation of 45 cytoplasmic amino acids, including those that make up the ITAM. Furthermore, the resultant protein resembles Igh-6 in that it contains only 3 charged cytoplasmic anchor amino acids. (J:66840)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd79b Mutation: 36 strains or lines available

References

• Original: J:66840 Reichlin A, et al., B cell development is arrested at the immature B cell stage in mice carrying a mutation in the cytoplasmic domain of immunoglobulin beta. J Exp Med. 2001 Jan 1;193(1):13-23
• All: 2 reference(s)