Cd79a^tm1.1Cgn
Targeted Allele Detail

Summary

• Symbol: Cd79a^tm1.1Cgn
• Name: CD79A antigen (immunoglobulin-associated alpha); targeted mutation 1.1, University of Cologne
• MGI ID: MGI:2388326
• Synonyms: Igalpha^FF
• Gene: Cd79a Location: Chr7:24596922-24601283 bp, + strand Genetic Position: Chr7, 13.49 cM
• Alliance: Cd79a^tm1.1Cgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71100
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion, Nucleotide substitutions
• Mutation details: This allele is derived from Cd79a^tm1Cgn by crossing mutant animals to a cre deleter line. Cre-mediated recombination results in removal of the floxed region containing endogenous exons 4-5. The deletion leaves behind duplicated exons carrying tyrosine to phenylalanine mutations at positions 182 and 193 of the ITAM motif. The correct sequence of the amino acid substitutions in mutant animals was verified by sequence analysis. (J:71100)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd79a Mutation: 22 strains or lines available

References

• Original: J:71100 Kraus M, et al., Interference with immunoglobulin (Ig)alpha immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation modulates or blocks B cell development, depending on the availability of an Igbeta cytoplasmic tail. J Exp Med. 2001 Aug 20;194(4):455-69
• All: 4 reference(s)