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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Eif2s1tm1Rjk
targeted mutation 1, Randal J Kaufman
MGI:2388264
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Eif2s1tm1Rjk/Eif2s1tm1Rjk involves: 129S1/Sv * 129X1/SvJ MGI:2651656
cx2
 		Eif2s1tm1Rjk/Eif2s1+
Ppp1r15btm1Dron/Ppp1r15btm1Dron 		involves: 129P2/OlaHsd MGI:3833923
cx3
 		Eif2s1tm1Rjk/Eif2s1tm1Rjk
Ppp1r15btm1Dron/Ppp1r15btm1Dron 		involves: 129P2/OlaHsd MGI:3833924
cx4
 		Eif2s1tm1Rjk/Eif2s1tm1Rjk
Ppp1r15atm1Dron/Ppp1r15atm1Dron
Ppp1r15btm1Dron/Ppp1r15btm1Dron 		involves: 129P2/OlaHsd * 129S6/SvEvTac MGI:3833928


Genotype
MGI:2651656
hm1
Allelic
Composition		 Eif2s1tm1Rjk/Eif2s1tm1Rjk
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2s1tm1Rjk mutation (1 available); any Eif2s1 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:70004 )
• neonates died within 18 hours after birth

behavior/neurological
abnormal suckling behavior ( J:70004 )
• neonates did not nurse

endocrine/exocrine glands
decreased insulin secretion ( J:70004 )
• insulin level of neonatal pancreas was 35% of wild-type

homeostasis/metabolism
decreased insulin secretion ( J:70004 )
• insulin level of neonatal pancreas was 35% of wild-type
hypoglycemia ( J:70004 )
• severe hypoglycemia ensued 6-9 hours after birth
decreased circulating insulin level ( J:70004 )
• neonatal serum insulin level was 20% of wild-type




Genotype
MGI:3833923
cx2
Allelic
Composition		 Eif2s1tm1Rjk/Eif2s1+
Ppp1r15btm1Dron/Ppp1r15btm1Dron
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2s1tm1Rjk mutation (1 available); any Eif2s1 mutation (57 available)
Ppp1r15btm1Dron mutation (0 available); any Ppp1r15b mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased fetal weight ( J:144954 )
• at E18.5

hematopoietic system




Genotype
MGI:3833924
cx3
Allelic
Composition		 Eif2s1tm1Rjk/Eif2s1tm1Rjk
Ppp1r15btm1Dron/Ppp1r15btm1Dron
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2s1tm1Rjk mutation (1 available); any Eif2s1 mutation (57 available)
Ppp1r15btm1Dron mutation (0 available); any Ppp1r15b mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:144954 )
• mice die after birth due to hypoglycemia

hematopoietic system
decreased erythrocyte cell number ( J:144954 )
• at E18.5, red blood cell counts are less than in wild-type mice but greater than in Ppp1r15btm1Dron homozygotes

growth/size/body
decreased fetal weight ( J:144954 )
• at E18.5, weight is less than in wild-type mice but greater than in Ppp1r15btm1Dron homozygotes

homeostasis/metabolism




Genotype
MGI:3833928
cx4
Allelic
Composition		 Eif2s1tm1Rjk/Eif2s1tm1Rjk
Ppp1r15atm1Dron/Ppp1r15atm1Dron
Ppp1r15btm1Dron/Ppp1r15btm1Dron
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2s1tm1Rjk mutation (1 available); any Eif2s1 mutation (57 available)
Ppp1r15atm1Dron mutation (0 available); any Ppp1r15a mutation (23 available)
Ppp1r15btm1Dron mutation (0 available); any Ppp1r15b mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:144954 )
N
• mice survive until E17.5

growth/size/body
growth/size/body region phenotype ( J:144954 )
N
• unlike Ppp1r15btm1Dron homozygotes, mice are of normal size at E17.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory