Phenotypes associated with this allele

• Allele Symbol: Fut4^tm1Jbl
• Allele Name: targeted mutation 1, John Lowe
• Allele ID: MGI:2387994
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fut4^tm1Jbl/Fut4^tm1Jbl	B6.129S2-Fut4^tm1Jbl	MGI:3652961
cx2	Fut4^tm1Jbl/Fut4^tm1Jbl Fut7^tm1Jbl/Fut7^tm1Jbl	B6.129S2-Fut7^tm1Jbl Fut4^tm1Jbl	MGI:3620054
cx3	Apoe^tm1Unc/Apoe^tm1Unc Fut4^tm1Jbl/Fut4^tm1Jbl Fut7^tm1Jbl/Fut7^tm1Jbl	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:3652962

Genotype
MGI:3652961

hm1

• Allelic Composition: Fut4^tm1Jbl/Fut4^tm1Jbl
• Genetic Background: B6.129S2-Fut4^tm1Jbl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

impaired leukocyte tethering or rolling ( J:79397 )

• decreased activity but rolling velocity increased

increased granulocyte number ( J:79397 )

increased eosinophil cell number ( J:79397 )

• modest

increased neutrophil cell number ( J:79397 )

• modest

increased monocyte cell number ( J:79397 )

• modest

hematopoietic system

impaired leukocyte tethering or rolling ( J:79397 )

• decreased activity but rolling velocity increased

increased granulocyte number ( J:79397 )

increased eosinophil cell number ( J:79397 )

• modest

increased neutrophil cell number ( J:79397 )

• modest

increased monocyte cell number ( J:79397 )

• modest

cellular

impaired leukocyte tethering or rolling ( J:79397 )

• decreased activity but rolling velocity increased

Genotype
MGI:3620054

cx2

• Allelic Composition: Fut4^tm1Jbl/Fut4^tm1Jbl; Fut7^tm1Jbl/Fut7^tm1Jbl
• Genetic Background: B6.129S2-Fut7^tm1Jbl Fut4^tm1Jbl

immune system

increased leukocyte cell number ( J:79397 )

• 2.9 fold increase in circulating leukocytes

increased neutrophil cell number ( J:79397 )

• 18 fold increase in neutrophiles

• increased production of neurophiles

abnormal leukocyte physiology ( J:79397 )

abnormal leukocyte migration ( J:79397 )

• reduced lymphocyte homing to peripheral and mesenteric lymph nodes

• migration to Peyer's patches unaffected

impaired leukocyte tethering or rolling ( J:79397 )

• total absence

abnormal neutrophil physiology ( J:79397 )

• remain in circulation for an extremely long period of time

• unable to bind E- or P-selectins

• absent recruitment to the dermis in inflammation

abnormal immune system organ morphology ( J:79397 )

abnormal lymph node primary follicle morphology ( J:79397 )

• small and infrequent but lymph node architecture is otherwise normal

small lymph nodes ( J:79397 )

• peripheral lymph nodes are small

lymph node hypoplasia ( J:79388 , J:79397 )

• 95% reduction of cellularity in peripheral lymph nodes (J:79388)

• reduced lymphocyte content (J:79397)

decreased susceptibility to type IV hypersensitivity reaction ( J:79388 )

• no hypersensitive response

decreased susceptibility to bacterial infection ( J:115682 )

• binding of A. phagocytophilum to neutrophils is severely reduced compared to in wild-type mice

• chemokine secretion induced by infection with A. phagocytophilum is reduced compared to in wild-type and Selplg^tm1Rpmc neutrophils

hematopoietic system

increased leukocyte cell number ( J:79397 )

• 2.9 fold increase in circulating leukocytes

increased neutrophil cell number ( J:79397 )

• 18 fold increase in neutrophiles

• increased production of neurophiles

abnormal leukocyte physiology ( J:79397 )

abnormal leukocyte migration ( J:79397 )

• reduced lymphocyte homing to peripheral and mesenteric lymph nodes

• migration to Peyer's patches unaffected

impaired leukocyte tethering or rolling ( J:79397 )

• total absence

abnormal neutrophil physiology ( J:79397 )

• remain in circulation for an extremely long period of time

• unable to bind E- or P-selectins

• absent recruitment to the dermis in inflammation

cellular

abnormal leukocyte migration ( J:79397 )

• reduced lymphocyte homing to peripheral and mesenteric lymph nodes

• migration to Peyer's patches unaffected

impaired leukocyte tethering or rolling ( J:79397 )

• total absence

Genotype
MGI:3652962

cx3

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Fut4^tm1Jbl/Fut4^tm1Jbl; Fut7^tm1Jbl/Fut7^tm1Jbl
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

cardiovascular system

atherosclerotic lesions ( J:102212 )

• decreased lesion size at 6 months of age