All Phenotypes Map3k14<tm1Rds> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map3k14^tm1Rds/Map3k14^tm1Rds	involves: 129	MGI:5446429
hm2	Map3k14^tm1Rds/Map3k14^tm1Rds	involves: 129/Sv * C57BL/6	MGI:2672103
cn3	Tbk1^tm1Arte/Tbk1^tm1Arte Map3k14^tm1Rds/Map3k14^tm1Rds Cd19^tm1(cre)Cgn/Cd19⁺	involves: 129/SvEv * 129P2/OlaHsd * C57BL/6	MGI:5446431

Allelic Composition	Map3k14^tm1Rds/Map3k14^tm1Rds
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k14^tm1Rds mutation (1 available); any Map3k14 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal class switch recombination ( J:188560 )

• defect in class switching to IgA when induced by anti-CD40 and BAFF

immune system

abnormal class switch recombination ( J:188560 )

• defect in class switching to IgA when induced by anti-CD40 and BAFF

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal thymus morphology ( J:68125 )

• abnormal architecture of the thymus

abnormal spleen morphology ( J:68125 )

• abnormal architecture of the spleen

decreased immunoglobulin level ( J:68125 )

• poor antibody responses, showing reduced IgG, IgM, IgA, IgG1, IgG2a, and IgG2b serum levels upon ovalbumin immunization, compared to wild-type

decreased IgA level ( J:68125 )

• decrease in serum IgA levels of unimmunized mice

decreased IgG2b level ( J:68125 )

• decrease in serum IgG2b levels of unimmunized mice

absent Peyer's patches ( J:68125 )

• do not develop Peyer's patches

absent mesenteric lymph nodes ( J:68125 )

absent axillary lymph nodes ( J:68125 )

absent cervical lymph nodes ( J:68125 )

absent inguinal lymph nodes ( J:68125 )

absent popliteal lymph nodes ( J:68125 )

absent lymph nodes ( J:68125 )

• lack all lymph nodes, including cervical, inguinal, mesenteric, popliteal, and axillary lymph node

hematopoietic system

abnormal thymus morphology ( J:68125 )

• abnormal architecture of the thymus

abnormal spleen morphology ( J:68125 )

• abnormal architecture of the spleen

decreased immunoglobulin level ( J:68125 )

• poor antibody responses, showing reduced IgG, IgM, IgA, IgG1, IgG2a, and IgG2b serum levels upon ovalbumin immunization, compared to wild-type

decreased IgA level ( J:68125 )

• decrease in serum IgA levels of unimmunized mice

decreased IgG2b level ( J:68125 )

• decrease in serum IgG2b levels of unimmunized mice

endocrine/exocrine glands

abnormal thymus morphology ( J:68125 )

• abnormal architecture of the thymus

Allelic Composition	Tbk1^tm1Arte/Tbk1^tm1Arte Map3k14^tm1Rds/Map3k14^tm1Rds Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
Map3k14^tm1Rds mutation (1 available); any Map3k14 mutation (41 available)
Tbk1^tm1Arte mutation (0 available); any Tbk1 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:188560 )

• no significant increase in the production of IgA+ compared to mice homozygous for Map3k14^tm1Rds alone

abnormal immunoglobulin level ( J:188560 )

• unlike mutant mice wild-type for Map3k14 the serum titer of IgA is not elevated

hematopoietic system

abnormal B cell differentiation ( J:188560 )

• no significant increase in the production of IgA+ compared to mice homozygous for Map3k14^tm1Rds alone

abnormal immunoglobulin level ( J:188560 )

• unlike mutant mice wild-type for Map3k14 the serum titer of IgA is not elevated

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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