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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Map3k14tm1Rds
targeted mutation 1, Robert D Schreiber
MGI:2387668
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Map3k14tm1Rds/Map3k14tm1Rds involves: 129 MGI:5446429
hm2
 		Map3k14tm1Rds/Map3k14tm1Rds involves: 129/Sv * C57BL/6 MGI:2672103
cn3
 		Tbk1tm1Arte/Tbk1tm1Arte
Map3k14tm1Rds/Map3k14tm1Rds
Cd19tm1(cre)Cgn/Cd19+ 		involves: 129/SvEv * 129P2/OlaHsd * C57BL/6 MGI:5446431


Genotype
MGI:5446429
hm1
Allelic
Composition		 Map3k14tm1Rds/Map3k14tm1Rds
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k14tm1Rds mutation (1 available); any Map3k14 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal class switch recombination ( J:188560 )
• defect in class switching to IgA when induced by anti-CD40 and BAFF

immune system
abnormal class switch recombination ( J:188560 )
• defect in class switching to IgA when induced by anti-CD40 and BAFF




Genotype
MGI:2672103
hm2
Allelic
Composition		 Map3k14tm1Rds/Map3k14tm1Rds
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k14tm1Rds mutation (1 available); any Map3k14 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
absent Peyer's patches ( J:68125 )
• do not develop Peyer's patches
abnormal thymus morphology ( J:68125 )
• abnormal architecture of the thymus
abnormal spleen morphology ( J:68125 )
• abnormal architecture of the spleen
decreased immunoglobulin level ( J:68125 )
• poor antibody responses, showing reduced IgG, IgM, IgA, IgG1, IgG2a, and IgG2b serum levels upon ovalbumin immunization, compared to wild-type
decreased IgA level ( J:68125 )
• decrease in serum IgA levels of unimmunized mice
decreased IgG2b level ( J:68125 )
• decrease in serum IgG2b levels of unimmunized mice
absent lymph nodes ( J:68125 )
• lack all lymph nodes, including cervical, inguinal, mesenteric, popliteal, and axillary lymph node

hematopoietic system
abnormal thymus morphology ( J:68125 )
• abnormal architecture of the thymus
abnormal spleen morphology ( J:68125 )
• abnormal architecture of the spleen
decreased immunoglobulin level ( J:68125 )
• poor antibody responses, showing reduced IgG, IgM, IgA, IgG1, IgG2a, and IgG2b serum levels upon ovalbumin immunization, compared to wild-type
decreased IgA level ( J:68125 )
• decrease in serum IgA levels of unimmunized mice
decreased IgG2b level ( J:68125 )
• decrease in serum IgG2b levels of unimmunized mice

endocrine/exocrine glands
abnormal thymus morphology ( J:68125 )
• abnormal architecture of the thymus

digestive/alimentary system
absent Peyer's patches ( J:68125 )
• do not develop Peyer's patches




Genotype
MGI:5446431
cn3
Allelic
Composition		 Tbk1tm1Arte/Tbk1tm1Arte
Map3k14tm1Rds/Map3k14tm1Rds
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129/SvEv * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (12 available); any Cd19 mutation (57 available)
Map3k14tm1Rds mutation (1 available); any Map3k14 mutation (42 available)
Tbk1tm1Arte mutation (0 available); any Tbk1 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:188560 )
• no significant increase in the production of IgA+ compared to mice homozygous for Map3k14tm1Rds alone
abnormal immunoglobulin level ( J:188560 )
• unlike mutant mice wild-type for Map3k14 the serum titer of IgA is not elevated

hematopoietic system
abnormal B cell differentiation ( J:188560 )
• no significant increase in the production of IgA+ compared to mice homozygous for Map3k14tm1Rds alone
abnormal immunoglobulin level ( J:188560 )
• unlike mutant mice wild-type for Map3k14 the serum titer of IgA is not elevated




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory