Tbk1^tm1Arte
Targeted Allele Detail

Summary

• Symbol: Tbk1^tm1Arte
• Name: TANK-binding kinase 1; targeted mutation 1, TaconicArtemis
• MGI ID: MGI:5446427
• Synonyms: Tbk1^fl
• Gene: Tbk1 Location: Chr10:121382360-121422692 bp, - strand Genetic Position: Chr10, 69.84 cM
• Alliance: Tbk1^tm1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188560
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 2 via homologous recombination. (J:188560)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbk1 Mutation: 54 strains or lines available

References

• Original: J:188560 Jin J, et al., The kinase TBK1 controls IgA class switching by negatively regulating noncanonical NF-kappaB signaling. Nat Immunol. 2012 Nov;13(11):1101-9
• All: 7 reference(s)