Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps6tm1Gtho mutation
(0 available);
any
Rps6 mutation
(12 available)
Tg(KRT5-cre)5132Jlj mutation
(1 available)
Trp53tm1Tyj mutation
(12 available);
any
Trp53 mutation
(232 available)
|
|
|
pigmentation
|
|
• mice exhibit an intermediate footpad pigmentation phenotype and reduced Kitl mRNA levels in the footpad epidermis at P30, indicating partial amelioration of the dark skin observed in mice that are only heterozygous for Rps6tm1Gtho and hemizygous for Tg(KRT5-cre)5132Jlj
|
integument
|
|
• mice exhibit an intermediate footpad pigmentation phenotype and reduced Kitl mRNA levels in the footpad epidermis at P30, indicating partial amelioration of the dark skin observed in mice that are only heterozygous for Rps6tm1Gtho and hemizygous for Tg(KRT5-cre)5132Jlj
|
limbs/digits/tail
|
|
• mice exhibit an intermediate footpad pigmentation phenotype and reduced Kitl mRNA levels in the footpad epidermis at P30, indicating partial amelioration of the dark skin observed in mice that are only heterozygous for Rps6tm1Gtho and hemizygous for Tg(KRT5-cre)5132Jlj
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps6tm1Gtho mutation
(0 available);
any
Rps6 mutation
(12 available)
Tg(KRT5-cre)5132Jlj mutation
(1 available)
Trp53tm1Tyj mutation
(12 available);
any
Trp53 mutation
(232 available)
|
|
|
pigmentation
|
N |
• mice exhibit normal footpad pigmentation and normal Kitl mRNA levels in the footpad epidermis at P30, indicating complete reversal of the phenotype observed in mice that are only heterozygous for Rps6tm1Gtho and hemizygous for Tg(KRT5-cre)5132Jlj
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps6tm1Gtho mutation
(0 available);
any
Rps6 mutation
(12 available)
Tg(Mx1-cre)1Cgn mutation
(7 available)
|
|
|
cellular
|
|
• mice induced with interferon gamma exhibited similar responses to starvation as controls, although it was noted that 40S ribosomes were absent and 60S ribosomes were increased in number in mutant liver recovering from starvation
|
|
|
• expression of cell cycle markers such as cyclin E and cyclin A were not seen in mutant hepatocytes suggesting a block in cell cycle progression
|
liver/biliary system
|
|
• after partial hepatectomy, mutant liver failed to regenerate after 10 days; histopathology revealed no evidence of regenerative or pathological processes in mutant liver; expression of cell cycle markers such as cyclin E and cyclin A were not seen in mutants suggesting a block in cell cycle progression
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps6tm1Gtho mutation
(0 available);
any
Rps6 mutation
(12 available)
Tg(Mitf-cre)7114Gsb mutation
(0 available)
|
|
|
pigmentation
|
|
• mice exhibit slightly decreased dermal pigmentation relative to control mice
|
|
|
• mice exhibit decreased epidermal pigmentation relative to control mice
|
|
|
• mice exhibit lighter skin than control mice; both the epidermis and, to a lesser extent, the dermis are affected
|
integument
|
|
• mice exhibit slightly decreased dermal pigmentation relative to control mice
|
|
|
• mice exhibit decreased epidermal pigmentation relative to control mice
|
|
|
• mice exhibit lighter skin than control mice; both the epidermis and, to a lesser extent, the dermis are affected
|
limbs/digits/tail
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps6tm1Gtho mutation
(0 available);
any
Rps6 mutation
(12 available)
Tg(KRT5-cre)5132Jlj mutation
(1 available)
|
|
|
pigmentation
|
|
• mice exhibit markedly darkened ears relative to control mice
|
|
|
• mice exhibit markedly darkened hair relative to control mice
|
|
|
• mice show increased epidermal pigmentation in the footpads, tail and ears
|
|
|
• mice exhibit markedly darkened footpads relative to control mice
• Kitl (kit ligand) mRNA levels are increased 8.2- and 3.8-fold at P3 and P30, respectively, in the footpad epidermis relative to control mice
• i.p. injection of ACK2 (a Kit-neutralizing antibody) at P2 prevents the appearance of dark footpads at P8 whereas PBS injection has no effect on pigmentation, indicating that Kit signaling is required for dark skin
• at P30, a 73-fold increase in Trp53 staining is noted in the basal layer of the footpad epidermis relative to control mice
|
|
|
• mice exhibit markedly darkened tails relative to control mice
• pigment accumulates in the tail epidermis, whereas the dermis is unaffected
|
integument
|
|
• mice exhibit markedly darkened ears relative to control mice
|
|
|
• mice exhibit markedly darkened hair relative to control mice
|
|
|
• mice show increased epidermal pigmentation in the footpads, tail and ears
|
|
|
• mice exhibit markedly darkened footpads relative to control mice
• Kitl (kit ligand) mRNA levels are increased 8.2- and 3.8-fold at P3 and P30, respectively, in the footpad epidermis relative to control mice
• i.p. injection of ACK2 (a Kit-neutralizing antibody) at P2 prevents the appearance of dark footpads at P8 whereas PBS injection has no effect on pigmentation, indicating that Kit signaling is required for dark skin
• at P30, a 73-fold increase in Trp53 staining is noted in the basal layer of the footpad epidermis relative to control mice
|
|
|
• mice exhibit markedly darkened tails relative to control mice
• pigment accumulates in the tail epidermis, whereas the dermis is unaffected
|
limbs/digits/tail
|
|
• mice exhibit markedly darkened footpads relative to control mice
• Kitl (kit ligand) mRNA levels are increased 8.2- and 3.8-fold at P3 and P30, respectively, in the footpad epidermis relative to control mice
• i.p. injection of ACK2 (a Kit-neutralizing antibody) at P2 prevents the appearance of dark footpads at P8 whereas PBS injection has no effect on pigmentation, indicating that Kit signaling is required for dark skin
• at P30, a 73-fold increase in Trp53 staining is noted in the basal layer of the footpad epidermis relative to control mice
|
|
|
• mice exhibit markedly darkened tails relative to control mice
• pigment accumulates in the tail epidermis, whereas the dermis is unaffected
|
craniofacial
|
|
• mice exhibit markedly darkened ears relative to control mice
|
hearing/vestibular/ear
|
|
• mice exhibit markedly darkened ears relative to control mice
|
growth/size/body
|
|
• mice exhibit markedly darkened ears relative to control mice
|
Analysis Tools