Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Usp18tm1Dez mutation
(1 available);
any
Usp18 mutation
(25 available)
|
|
|
mortality/aging
behavior/neurological
cardiovascular system
|
• bloody cerebrospinal fluid was noted
|
nervous system
|
• bloody cerebrospinal fluid was noted
|
|
• hydroencephaly first appears at postnatal day 14
|
|
• bilateral enlargement of lateral ventricle and third ventricle
|
|
• bilateral enlargement of lateral ventricle and third ventricle
|
|
• thinned cerebral cortex
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Usp18tm1Dez mutation
(1 available);
any
Usp18 mutation
(25 available)
|
|
|
immune system
|
• MHV-3 infection does not induce type I or type II IFN induction in primary hepatocytes
• MHV-3-infected peritoneal exudative macrophages do not show increased type I IFN signaling
|
|
• MHV-3-infected mice show no induction of IFN-alpha hepatic mRNA and serum protein levels as seen in wild-type mice
|
|
• MHV-3-infected mice show no induction of IFN-beta hepatic mRNA and serum protein levels as seen in wild-type mice
|
|
• MHV-3-infected mice show no induction of IFN-gamma hepatic mRNA and serum protein levels as seen in wild-type mice
|
|
• mice infected with the murine hepatitis virus strain 3 (MHV-3) coronavirus exhibit extended survival (up to 10 days compared to 4 in wild-type) and improved liver histology, decreased inflammatory response, and decreased viral titers than wild-type mice, however, infection gradually does lead to widespread liver damage of 40-50% focal necrosis but never as severe as in wild-type mice and mice eventually succumb to infection
|
homeostasis/metabolism
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Usp18ity9 mutation
(0 available);
any
Usp18 mutation
(25 available)
Usp18tm1Dez mutation
(1 available);
any
Usp18 mutation
(25 available)
|
|
|
mortality/aging
|
• Salmonella-infected mice exhibit increased mortality compared with wild-type mice
|
immune system
|
• Salmonella-infected mice exhibit increased mortality and organ bacterial loads (6-fold higher in the spleen and 28-fold higher in the liver) compared with wild-type mice
|
|
• Salmonella-infected mice exhibit increased mortality compared with wild-type mice
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Uba7tm1Dez mutation
(0 available);
any
Uba7 mutation
(35 available)
Usp18tm1Dez mutation
(1 available);
any
Usp18 mutation
(25 available)
|
|
|
cellular
|
• bone marrow cells have almost double the amount of apoptotic cells as controls when cultured with interferon-alpha/beta
• the homozygote null Uba7tm1Dzh alleles do not rescue the increased sensitivity of Usp18tm1Dzh homozygote cells to IFN-mediated apoptosis
|