Usp18^ity9
Chemically induced Allele Detail

Summary

• Symbol: Usp18^ity9
• Name: ubiquitin specific peptidase 18; immunity to Typhimurium locus 9
• MGI ID: MGI:4830352
• Synonyms: USP18^L361F
• Gene: Usp18 Location: Chr6:121222865-121247876 bp, + strand Genetic Position: Chr6, 57.17 cM, cytoband F
• Alliance: Usp18^ity9 page

Mutation origin

• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a G to T transversion that results in the amino acid substitution of phenylalanine for leucine at position 361 (L361F). (J:163843)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Usp18 Mutation: 25 strains or lines available

References

• Original: J:163843 Richer E, et al., N-ethyl-N-nitrosourea-induced mutation in ubiquitin-specific peptidase 18 causes hyperactivation of IFN-alphabeta signaling and suppresses STAT4-induced IFN-gamma production, resulting in increased susceptibility to Salmonella Typhimurium. J Immunol. 2010 Sep 15;185(6):3593-601
• All: 3 reference(s)