All Phenotypes Gata4<tm1Sho> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gata4^tm1Sho
targeted mutation 1, Stuart Orkin
MGI:2386764

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gata4^tm1Sho/Gata4^tm1Sho	involves: 129S6/SvEvTac	MGI:2665406
ht2	Gata4^tm1Sho/Gata4⁺	C57BL/6JEi-Chr Y^A/HeJ/EiJ	MGI:6479102
cn3	Gata4^tm1Sho/Gata4⁺ Tg(Myh6-cre)2182Mds/0	involves: 129S6/SvEvTac	MGI:3851413
cn4	Gata4^tm1Sho/Gata4⁺ Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺	involves: 129S6/SvEvTac * 129S7/SvEvBrd	MGI:3851410
cn5	Gata4^tm1Sho/Gata4^tm1.1Wtp Tg(Myh6-cre)2182Mds/0	involves: 129S6/SvEvTac * 129S7/SvEvBrd	MGI:3851409
cn6	Gata4^tm1Sho/Gata4^tm1.1Wtp Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺	involves: 129S6/SvEvTac * 129S7/SvEvBrd	MGI:3851408
cx7	Gata4^tm1Sho/Gata4^tm1Sho Gata6^tm1Kgac/Gata6^tm1Kgac	involves: 129S1/Sv * 129S6/SvEvTac	MGI:3789027

Allelic Composition	Gata4^tm1Sho/Gata4^tm1Sho
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4^tm1Sho mutation (0 available); any Gata4 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:77392 )

• death around E12.5

cardiovascular system

thin myocardium ( J:77392 )

abnormal truncus arteriosus septation ( J:77392 )

• pulmonary and aortic outflow tracts comingle

abnormal heart development ( J:77392 )

abnormal conotruncal ridge morphology ( J:77392 )

• endocardial cushion cells of both pulmonary and aortic outflow tracts appear more numerous

absent coronary vessels ( J:77392 )

• absence of coronary vasculature

double outlet right ventricle ( J:77392 )

common atrioventricular valve ( J:77392 )

• exhibit a common atroventricular valve situated between the left and right ventricles that has no fibrous continuity with the aortic valve

atrial septal defect ( J:77392 )

dilated heart atrium ( J:77392 )

• right and left atria are massively dilated and freely communicate

abnormal heart ventricle morphology ( J:77392 )

common ventricle ( J:77392 )

ventricular septal defect ( J:77392 )

• providing the only outlet from the left ventricle

hemorrhage ( J:77392 )

• often observe peripheral hemorrhage

reproductive system

abnormal Sertoli cell morphology ( J:78688 )

• blocked differentiation

abnormal fetal Leydig cell differentiation ( J:78688 )

• maturation of leydig cells was not initiated

abnormal primary sex determination ( J:78688 )

primary sex reversal ( J:78688 )

• gonads of XY mice develop as ovaries

• XX mice develop abnormal ovaries

respiratory system

abnormal lung development ( J:134027 )

• lungs cultured from E11.5 embryos lack accessory lobe and accessory bud development and show a mild growth delay

homeostasis/metabolism

edema ( J:77392 )

endocrine/exocrine glands

abnormal Sertoli cell morphology ( J:78688 )

• blocked differentiation

abnormal fetal Leydig cell differentiation ( J:78688 )

• maturation of leydig cells was not initiated

integument

pallor ( J:77392 )

muscle

thin myocardium ( J:77392 )

Allelic Composition	Gata4^tm1Sho/Gata4⁺
Genetic Background	C57BL/6JEi-Chr Y^A/HeJ/EiJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4^tm1Sho mutation (0 available); any Gata4 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

primary sex reversal ( J:125196 )

• Background Sensitivity: heterozygous carriers with the A/HeJ Y Chromosome on the C57BL/6JEi background develop ovaries

true hermaphroditism ( J:125196 )

Allelic Composition	Gata4^tm1Sho/Gata4⁺ Tg(Myh6-cre)2182Mds/0
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4^tm1Sho mutation (0 available); any Gata4 mutation (37 available)
Tg(Myh6-cre)2182Mds mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:150452 )

N	• animals show normal development

Allelic Composition	Gata4^tm1Sho/Gata4⁺ Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4^tm1Sho mutation (0 available); any Gata4 mutation (37 available)
Nkx2-5^tm1(cre)Rjs mutation (1 available); any Nkx2-5 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:150452 )

N	• animals show normal development

Allelic Composition	Gata4^tm1Sho/Gata4^tm1.1Wtp Tg(Myh6-cre)2182Mds/0
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4^tm1.1Wtp mutation (0 available); any Gata4 mutation (37 available)
Gata4^tm1Sho mutation (0 available); any Gata4 mutation (37 available)
Tg(Myh6-cre)2182Mds mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Reduced coronary microvasculature, decreased capillary density and increased fibrosis in Gata4^tm1.1Wtp/Gata4^tm1Sho Tg(Myh6-cre)2182Mds/0 hearts

cardiovascular system

dilated heart ventricle ( J:150452 )

• ventricular dilation is observed

abnormal cardiovascular system physiology ( J:150452 )

• severely diminished systolic function at 8-14 weeks

Allelic Composition	Gata4^tm1Sho/Gata4^tm1.1Wtp Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Edema, peripheral hemorrhage, and reduced coronary plexus in Gata4^tm1.1Wtp/Gata4^tm1Sho Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ embryos and enlarged dilated ventricles and increased fibrosis in Gata4^tm1.1Wtp/Gata4^tm1Sho Tg(Myh6-cre)2182Mds/0 hearts

cardiovascular system

thin myocardium compact layer ( J:150452 )

• compact myocardium is thin

abnormal atrioventricular cushion morphology ( J:150452 )

• atrio-ventricular cushion defect is observed

abnormal coronary vessel morphology ( J:150452 )

• coronary vascular development is impaired

ventricular septal defect ( J:150452 )

• ventricular septal defect is observed

hemorrhage ( J:150452 )

• peripheral hemorrhage is observed at E13.5

homeostasis/metabolism

skin edema ( J:150452 )

• observed at E13.5

integument

skin edema ( J:150452 )

• observed at E13.5

muscle

thin myocardium compact layer ( J:150452 )

• compact myocardium is thin

Allelic Composition	Gata4^tm1Sho/Gata4^tm1Sho Gata6^tm1Kgac/Gata6^tm1Kgac
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4^tm1Sho mutation (0 available); any Gata4 mutation (37 available)
Gata6^tm1Kgac mutation (0 available); any Gata6 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

abnormal lung development ( J:134027 )

• lungs cultured from E11.5 embryos lack accessory lobe and accessory bud development and show a mild growth delay

• the phenotype of double mutants is not more severe than that of Gata4 single homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24